Formulation, Evaluation, And Anti-Inflammatory Activity Of An Oral Herbal Suspension Of Boerhavia Diffusa Root Extract
Keywords:
Boerhavia diffusa, herbal suspension, anti-inflammatory activity, paw edema, phytochemical evaluationAbstract
The present study aims to develop and evaluate an oral herbal suspension containing Boerhavia diffusa root extract as a potential anti-inflammatory agent. Boerhavia diffusa is a traditional medicinal plant known for its diuretic, hepatoprotective, and anti-inflammatory properties. The formulation was developed using standard pharmaceutical excipients, and the suspension was evaluated for physical parameters such as pH, viscosity, sedimentation volume, and redispersibility. The anti-inflammatory activity was assessed using the carrageenan-induced paw edema method in Wistar rats, comparing the results with a standard drug (diclofenac sodium). The formulated suspension demonstrated significant anti-inflammatory activity, comparable to the standard, with good physicochemical stability and patient acceptability. These findings support the use of Boerhavia diffusa as a natural anti-inflammatory agent in oral suspension form
Downloads
References
Prajapati ND, Purohit SS, Sharma AK, Kumar T. A Handbook of Medicinal Plants. Jodhpur: Agrobios; 2003.
Singh A, Duggal S. Boerhavia diffusa: A review on its phytochemical and pharmacological profile. Asian J Biomed Pharm Sci. 2009;1(1):1–5.
Dwivedi S, Sangwan P. Pharmacognostical and phytopharmacological review of Boerhavia diffusa. Int J Pharm Sci Res. 2012;3(2):408–15.
Pandey G, Madhuri S. Pharmacological activities of some selected medicinal plants: A review. Int J Pharma Sci Res. 2010;1(1):1–10.
Ghosh MN. Fundamentals of Experimental Pharmacology. 6th ed. Kolkata: Hilton & Company; 2015.
Gupta AK, Tandon N, Sharma M. Quality Standards of Indian Medicinal Plants. Vol. 1. New Delhi: Indian Council of Medical Research; 2003.
Harborne JB. Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis. 3rd ed. London: Springer; 1998.
Khandelwal KR. Practical Pharmacognosy Techniques and Experiments. 20th ed. Pune: Nirali Prakashan; 2010.
OECD. OECD Guidelines for Testing of Chemicals: Test No. 425 – Acute Oral Toxicity: Up-and-Down Procedure. Paris: Organisation for Economic Co-operation and Development; 2008.
Indian Pharmacopoeia. Vol. 2. New Delhi: Government of India, Ministry of Health and Family Welfare; 2018.
Sweetman SC, editor. Martindale: The Complete Drug Reference. 38th ed. London: Pharmaceutical Press; 2014.
British Pharmacopoeia Commission. British Pharmacopoeia 2023. London: TSO (The Stationery Office); 2023.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.