Anti-Inflammatory Potential of a Novel Oral Suspension Formulated with Prosopis Cineraria Pod Extract
Keywords:
Prosopis cineraria, anti-inflammatory, herbal medicine, oral suspension, phytoconstituentsAbstract
Inflammation is a natural defense mechanism of the body against injury, infection, or irritation. However, chronic or excessive inflammation can lead to various health issues. While synthetic anti-inflammatory drugs are available, they often come with side effects. This has led researchers to explore herbal alternatives, which are generally considered safer. Prosopis cineraria, commonly known as "Khejri," is a tree native to arid regions and has been traditionally used in Indian medicine to treat ailments like fever, asthma, and joint pain. Its pods, leaves, and bark are rich in natural compounds such as flavonoids, tannins, phenols, and alkaloids, which possess anti-inflammatory properties. This study focuses on extracting phytoconstituents from Prosopis cineraria pods, formulating a stable oral suspension, and evaluating its physicochemical properties and in vitro anti-inflammatory activity. The formulated suspension underwent various tests, including organoleptic evaluation, pH measurement, viscosity determination, sedimentation volume, redispersibility, flow rate, particle size analysis, microbial load testing, and stability studies as per ICH guidelines. In vitro anti-inflammatory activity was assessed using protein denaturation assay, HRBC membrane stabilization method, and nitric oxide scavenging assay. The results indicated that the Prosopis cineraria extract exhibited significant anti-inflammatory activity, suggesting its potential as a natural alternative to synthetic anti-inflammatory drugs
Downloads
Metrics
References
Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454(7203):428-435.
Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol. 2011;31(5):986-1000.
Shahidi F, Ambigaipalan P. Phenolics and polyphenolics in foods, beverages, and spices: antioxidant activity and health effects – A review. J Funct Foods. 2015;18:820-897.
Kaushik P, Singh G. Khejri (Prosopis cineraria): A tree of multiple uses. Indian J Tradit Knowl. 2011;10(3):414-417.
Panche AN, Diwan AD, Chandra SR. Flavonoids: An overview. J Nutr Sci. 2016;5:e47.
Smith J, Brown L, Lee H. Extraction and characterization of bioactive compounds from plant pods using Soxhlet apparatus. J Pharm Sci. 2020;45(3):123-129.
Harborne JB. Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis. 3rd ed. London: Springer; 1998.
Sofowora A. Medicinal Plants and Traditional Medicine in Africa. 2nd ed. Ibadan, Nigeria: Spectrum Books; 1993.
Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic. 1965;16(3):144-158.
Prajapati N, Purohit S, Sharma A, Kumar T. A review on formulation and evaluation of herbal suspensions. Int J Pharm Sci Res. 2013;4(9):3484-3494.
Pandey P, Sharma A, Sharma H, Vyas GK, Sharma M. Novel researched herbal sunscreen cream SPF determination by in-vitro model. Asian J Pharm Res Dev. 2023 Apr 25;11(2):83-90.
Roopa G, Bhat RS, Dakshina MS. Formulation and evaluation of an antacid and anti-ulcer suspension containing herbal drugs. Biomed Pharmacol J. 2015 Mar 25;3(1):1-6.
Sakat SS, Juvekar AR, Gambhire MN. In vitro anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. J Pharm Pharmacol. 2010;62(3):1041-1046.
Banu SS, Prabhu V. Anti-inflammatory activity of plant extracts in the HRBC membrane stabilization method. Int J Pharm Sci Res. 2016;7(4):1561-1567.
Patel S, Goyal RK. In vitro evaluation of nitric oxide scavenging activity of Prosopis cineraria. J Ethnopharmacol. 2010;129(1):175-178.
Vyas GK, Sharma A, Sharma M, Nama N. Poly-herbal formulation on burn wound healing for diabetic albino rats. J Pharm Sci Res. 2023;15(2):213-217.
Patel MA, Patel PA. Formulation and evaluation of anti-inflammatory suspensions. Int J Pharm Sci Res. 2013;4(6):2292-2298...
.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
