Spectrum of Acute Pancreatitis in the Kashmiri Population: Experience of 250 Cases In Tertiary Care Hospital
Keywords:
Pancreatitis, WOPN, Cystogastrostomy, Kashmir, Gallstones, AscariasisAbstract
Background: Acute pancreatitis (AP) is an inflammatory condition with multiple etiologies, ranging from gallstones and alcohol consumption to metabolic and idiopathic causes. In Kashmir, a region known for its distinct dietary patterns and high prevalence of gallstone disease and Ascariasis, AP presents unique epidemiological characteristics .This study aims to analyze the clinical spectrum of AP in the Kashmiri population through a prospective approach.
Methods: This hospital-based prospective study was conducted in department of Medical Gastroenterology, GMC Srinagar from December 2022 to December 2024 and included 250 patients diagnosed with Acute Pancreatitis. Data on Demographics, etiology, severity, interventions in severe pancreatitis and overall outcomes were analyzed.
Results: Demographic analysis showed that 60% (150/250) of the patients were male and 40% (100/250) were female. The mean age of presentation was 42 years .Gallstone-induced AP was the most common cause (42.8%) followed by Idiopathic (19.2%), worm induced(10.4%) and post-ERCP pancreatitis was seen in 7.2% of patients. cases. Based on severity Pancreatitis was classified into mild (55%), Moderate (30%) and Severe acute pancreatitis (SAP) (15%). Patients with SAP developed significant complications, including Pancreatic necrosis (60%), Systemic inflammatory response syndrome (SIRS): (45%), Multi-organ failure (MOF)(25% ), Acute respiratory distress syndrome (ARDS)(15% ) with ICU admission required in 50% and Mortality of 20% (8/38). A total of 22 patients of SAP underwent Cystogastrostomy. Endoscopic Cystogastrostomy was performed in 68% (15 patients) while Surgical Cystogastrostomy in 32%. The overall success rate of endoscopic Cystogastrostomy (CG) was 90%. Complete resolution of cysts occurred in most patients within 8 weeks. However, 10% required repeat drainage due to incomplete resolution. Complications observed Post CG included Infection (15%), Bleeding (5%), Stent migration (in endoscopic cases) in 10% Recurrence of cysts (5%).
Conclusion: Gallstones remain the predominant cause of AP in this region. Worm induced pancreatitis remains a unique cause in Kashmir due to endemicity. Alcohol consumption is an emerging concern. SAP carries a risk for developing significant morbidity and mortality. Early identification and management of risk factors are essential to reduce morbidity and mortality.
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