Development And Evaluation Of Polyherbal Self Nanoemulsifying Drug Delivery System (SNEDDS)

Authors

  • Arpita Mishra
  • Sachin Kumar Jain
  • Sudha Vengurlekar

Keywords:

Sudha Vengurlekar, Sachin Kumar Jain, Arpita Mishra

Abstract

An SNEDDS is a drug delivery system that uses a mixture of oils, surfactants, and co-surfactants to form a fine oil-in-water nano-emulsion when exposed to aqueous media, such as gastrointestinal fluids. This system is thermodynamically stable and can enhance the solubility and bioavailability of poorly soluble drugs, thereby improving their therapeutic efficacy. The current study’s aim was to formulate an polyherbs containing SNEDDS with a careful selection of its components, oils, surfactants, and co-surfactants.Surfactants are essential for emulsion stability, reducing interfacial tension between oil and water phases. This study employed hydrophilic non-ionic surfactants, including sesame oil, span 80 and Propylene glycol. The choice of these surfactants is supported by their high hydrophilic–lipophilic balance (HLB) values, which indicate their ability to stabilize O/W emulsions effectively. Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery..

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Published

2025-05-09

How to Cite

1.
Mishra A, Kumar Jain S, Vengurlekar S. Development And Evaluation Of Polyherbal Self Nanoemulsifying Drug Delivery System (SNEDDS). J Neonatal Surg [Internet]. 2025May9 [cited 2025May15];14(22S):91-101. Available from: https://jneonatalsurg.com/index.php/jns/article/view/5457

Issue

Vol. 14 No. 22S (2025): Journal of Neonatal Surgery

Section

Original Article

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