Formulation & Evaluation of Solid Dispersion of Torsemide
Keywords:
Solid Dispersion, Poorly Water Soluble, Torsemide, SolubilityAbstract
By using solid solubilizers, solid dispersion specifically seeks to increase the solubility of medications that are not very soluble in water. A mixture of solubilizers may be employed to increase the drug's solubility, which will lower the concentrations of each solubilizer alone and effectively increase the drug's solubility. The goal of this study is to make the medication torsemide more soluble in water. Three distinct batches of solid dispersions (SDA, SDB, and SDC) with varying ratios (1:4, 1:5, and 1:6) are made using precisely weighed sodium caprylate, beta cyclodextrin, sodium citrate, sodium acetate, water, and torsemide, and the temperature is kept between 70 and 80 degrees Celsius. Micromeritic Properties of Solid Dispersions, Powder X-Ray Diffraction Studies, Scanning Electron Microscopy, and Dissolution Rate Studies were used to assess the solid dispersion, and the SDA batch produced good results
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