Analytical Method Development of Process Related Impurities of drug Lacidipine by using RP HPLC Techniques
Keywords:
Lacidipine, High Performance Liquid Chromatography (HPLC), etcAbstract
The synthesis and Retro synthesis of Lacidipine was studied to determine the process-related impurities in Lacidipine formulation. The intermediates of the drug treated as impurities were decided and planned for the synthesis. General Method for 1,4dihyropyridine Synthesis was used. The purity of the intermediate was carried out by column chromatography using dimethyl sulfoxide (DMSO) as mobile phase. The technique was observed to be explicit, direct, delicate, exact and precise. The outcomes showed great middle of the road accuracy. Versatile stage stream rate seemed to have critical impact on power, and thus it was essential to be painstakingly controlled.
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References
Abraham D. J (2003), Medicinal chemistry Drug Discovery, Published by, A John Wiley and Sons, Publications, sixth edition, 1-46.
Adeleh M. Z and Nahid S (2010), Synthesis of 1,4-Dihydropyridine Derivatives Under Aqueous Media, E-Journal of Chemistry, 7(S1):S372-S376.
Ahuja S, Dong M. W (2009), Handbook of Pharmaceutical Analysis by HPLC, Published by, Academic Press Elsevier, first edition, 145-87, 359-376.
Ahuja S (2006), Impurities Evaluation of Pharmaceuticals, Published by, Special Indian Edition by Marcel Dekker Incorporation, first edition, 85-108.
AL-Ghannam S. M, AL-Olyan A. M (2009), Spectrophotometric determination of Nicradipine and Isradipine in pharmaceutical formulations, Chemical Industry & Chemical Engineering Quarterly, 15(2):69−76.
Raghuvanshi R. S, Singh K. N (2008), Superoxide induced oxidative aromatization of Hantzsch 1,4-Dihydropyridines, Indian Journal of Chemistry, 47B:1735-1738.
Arslan M, Faydali C, Zengin M, Kucukislamoglu M and Demirhan H (2009), An efficient one pot synthesis of 1,4-dihydropyridines using alumina sulfuric acid (ASA) catalyst, Turkish Journal of Chemistry, 33:769-774.
Bari S. B, Kadam B. R, Jaiswal Y. S, Shirkhekar A. A (2007), Impurity profile: Significance in Active Pharmaceutical Ingredient, Eurasian Journal of Analytical Chemistry, 2 (1):32-53.
Barmpalexis p, Kanaze F. I, Georgarakis E (2009), Developing and optimizing a validated isocratic reversed-phase high-performance liquid chromatography separation of Nimodipine and impurities in tablets using experimental design methodology, Journal of Pharmaceutical and Biomedical Analysis, 49:1192-1202.
Bartos D, Gorog S (2008), Recent Advances in the Impurity Profiling of Drugs, Current Pharmaceutical Analysis, 4(4):215-230.
Basak A. K, Raw A. S, Al Hakin A. H, Furness S, Samaan N. I, Patel H. B, Powers R. F, Lawrence Y (2007), Pharmaceutical Impurities: Regulatory Perspective for Abbreviated New Drug Applications, Advanced Drug Delivery Reviews, 59:64–72.
Block J. H, Beale J. M (2004), Wilson and Gisvold’sTextwook of Organic Medicinal and Pharmaceutical Chemistry, Lippincott Williams and Wilkins Publication, eleventh edition, 622-673.
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