Development And Evaluation Of Miconazole Nitrate Loaded Niosomal Suspension

Authors

  • Navneet Singh
  • Amerendra Singh
  • Jai Narayan Mishra

Keywords:

Niosome, FTIR, SEM, TEM, Miconazole, Transdermal delivery

Abstract

Niosomes, which are vesicular drug delivery vehicles made mostly of non-ionic surfactants, have a number of benefits over traditional formulations. Niosomes are a safer option than other nanoparticle-based carriers because of their improved stability, biodegradability, and decreased toxicity. These vesicles are very adaptable because they can contain both hydrophilic and lipophilic medications. They are especially useful in systemic applications like cancer therapy as well as topical and transdermal formulations like gels and creams because of their capacity to enhance drug penetration, maintain release, and target particular sites. The goal of this research is to maximize stability and integrity by optimizing the formulation of niosomes in the lab and testing various surfactant and cholesterol ratios. The study also attempts to evaluate the niosomal system's release behavior and drug loading efficiency. Thorough characterization methods, such as FTIR, TEM, SEM, and zeta potential analysis, are used to assess the physicochemical stability, morphology, and general performance of the prepared formulations

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Uchegbu, I. F., & Vyas, S. P. (1998). Non-ionic surfactant-based vesicles (niosomes) in drug delivery.International Journal of Pharmaceutics, 172(1-2), 33–70.

Kazi, K. M., Mandal, A. S., Biswas, N., Guha, A., Chatterjee, S., Behera, M., & Kuotsu, K. (2010).Niosome: A future of targeted drug delivery systems.Journal of Advanced Pharmaceutical Technology & Research, 1(4), 374–380.

Biju, S. S., Talegaonkar, S., Mishra, P. R., & Khar, R. K. (2006). Vesicular systems: An overview.Indian Journal of Pharmaceutical Sciences, 68(2), 141.

Chien, Y. W. (1992). Novel drug delivery systems (2nd ed.). New York: Marcel Dekker.

Jain, N. K. (Ed.). (2009). Controlled and novel drug delivery. New Delhi: CBS Publishers & Distributors.

Sweetman, S. C. (Ed.). (2009). Martindale: The complete drug reference (36th ed.). London: Pharmaceutical Press.

Aulton, M. E., & Taylor, K. (Eds.). (2013). Aulton's pharmaceutics: The science of dosage form design (4th ed.). Edinburgh: Churchill Livingstone.

Gibson, M. (Ed.). (2009). Pharmaceutical preformulation and formulation: A practical guide from candidate drug selection to commercial dosage form. Boca Raton: CRC Press.

Florence, A. T., & Attwood, D. (2011). Physicochemical principles of pharmacy (5th ed.). London: Pharmaceutical Press.

Gennaro, A. R. (Ed.). (2000). Remington: The science and practice of pharmacy (20th ed.). Philadelphia: Lippincott Williams & Wilkins.

Potdar, S. A. (2008). A practical approach to pharmaceutical analysis. Pune: Nirali Prakashan.

Chatwal, G. R., & Anand, S. K. (2008). Instrumental methods of analysis (5th ed.). Mumbai: Himalaya Publishing House.

Mendham, J., Denney, R. C., Barnes, J. D., & Thomas, M. J. K. (2000). Vogel’s textbook of quantitative chemical analysis (6th ed.). Harlow: Prentice Hall.

Jain, N. K. (Ed.). (2009). Controlled and novel drug delivery. New Delhi: CBS Publishers & Distributors.

Cornier, J., et al. (Eds.). (2017). Pharmaceutical nanotechnology: Fundamentals and practical applications. Cham: Springer.

Sinko, P. J. (2011). Martin’s physical pharmacy and pharmaceutical sciences (6th ed.). Philadelphia: Lippincott Williams & Wilkins.

Brahmankar, D. M., & Jaiswal, S. B. (2015). Biopharmaceutics and pharmacokinetics: A treatise (2nd ed.). New Delhi: Vallabh Prakashan.

Bhange, M. A., Pethe, A. M., & Jadhav, A. (2023). NIOSOMES A PROMISSING NANOCARRIER: A REVIEW. International Journal of Applied Pharmaceutics, 14–19. https://doi.org/10.22159/ijap.2023v15i6.47969

Shaik, A. P., & Naidu, V. (2024). Formulation, evaluation and characterization of hydrochlorothiazide niosomes. Future Journal of Pharmaceuticals and Health Sciences, 4(1), 69–79. https://doi.org/10.26452/fjphs.v4i1.566

Waghmare, N. D., Hiwe, K. A., Bakal, R. L., & Saware, U. S. (2025). Emulgel: A Novel Topical Drug Delivery System. ResearchGate. https://doi.org/10.22270/ajprd.v13i2.1545

Downloads

Published

2025-08-18

How to Cite

1.
Singh N, Singh A, Mishra JN. Development And Evaluation Of Miconazole Nitrate Loaded Niosomal Suspension. J Neonatal Surg [Internet]. 2025Aug.18 [cited 2025Sep.21];14(32S):7564-79. Available from: https://jneonatalsurg.com/index.php/jns/article/view/8902

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  • Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.