Design, Synthesis And Pharmacological Activity Of Novel Furan-Azetidinone Derivatives For Antimicrobial Activity
Keywords:
Azetidinones, Furan, Methodology, Antimicrobial- screeningAbstract
It is now necessary to create new, efficient agents with various scaffolds due to rising drug resistance and significant toxicity to the current medications. A technique was developed to hybridise the various heterocyclic moieties with the goal of discovering new antibacterial and antifungal compounds. Drawing from prior research, the four most promising derivatives were chosen and synthesised. When o-toluidine and ethyl cyanoacetate were condensed at 160–190 °C, 2-cyano-N-2(methylphenyl) acetamide (1) was produced. By reacting with benzoin, 2-amino-N-(2-methylphenyl) 4, 5-diphenylfuran-3-carboxamide (2) was produced. As a catalyst, concentrated sulphuric acid was used to reflux (2) with different substituted aromatic aldehydes in ethanol to create a series of Schiff bases ARJJ03 (A-B). By cyclizing ARJJ03 (A-B) with chloroacetyl chloride in 1, 4-dioxane while triethylamine was present, the title compounds ARJJ04 (A-B) were produced. The UV, IR, NMR, and mass spectral data were used to characterise the synthesised derivatives. Ciprofloxacin and ketoconazole were used as reference medications in the agar streak dilution method to investigate the in-vitro antibacterial activity of compounds [ARJJ04 (A-B)].
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