Amorphophallus Konjac as a Natural Modulator of Inflammation and Immunity in Cancer Therapy
Keywords:
Amorphophallus Konjac, Anti-Inflammatory, Immune Regulation, Cancer, Konjac glucomannanAbstract
Amorphophallus konjac is a perennial plant whose bioactive component, konjac glucomannan (KGM), has garnered increasing attention due to its broad therapeutic potential. While KGM has been traditionally utilised in East Asian medicine for detoxification and metabolic regulation, recent studies have highlighted its significant anti-inflammatory and immunomodulatory properties. This review aims to provide a focused synthesis of current evidence on the role of A. konjac and KGM in modulating immune responses and alleviating inflammation-related disorders. KGM has demonstrated efficacy in reducing pro-inflammatory cytokines such as TNF-α, IL-1β, IL-4, and IL-13, particularly in experimental models of colitis, atopic dermatitis, and skin inflammation. Additionally, KGM contributes to gut immune homeostasis by enhancing the growth of beneficial gut microbiota and promoting the production of short-chain fatty acids (SCFAs), which are key mediators in immune tolerance and mucosal defence. The polysaccharide also supports the activity of T-cells and macrophages, regulating the balance between pro-inflammatory and regulatory immune pathways. Beyond its localised effects, KGM exhibits systemic immunomodulatory benefits, suggesting a role in the prevention or adjunctive treatment of autoimmune and allergic conditions. Moreover, its application in wound healing further demonstrates its anti-inflammatory profile and biocompatibility. Despite its promising benefits, factors such as individual variability in immune responses and potential interactions with pharmacological agents necessitate further investigation. Future research should emphasise clinical trials to validate its therapeutic efficacy, dosage optimisation, and potential as a functional food or nutraceutical. In conclusion, A. konjac and its active compound, KGM, represent a compelling plant-based strategy for managing inflammation and supporting immune health through multifaceted mechanisms rooted in gut-immune interactions
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