Prevalence, Incidence and Mortality Rates of Cervical Cancer in India: based on Global Burden
DOI:
https://doi.org/10.63682/jns.v14i32S.9162Keywords:
Incidence, mortality, Global Burden, Cervical Cancer, IndiaAbstract
Background: According to the latest GLOBOCAN statistics, cervical cancer ranks as the fourth most common cancer in terms of incidence and mortality among women worldwide, following only breast cancer, colorectal cancer, and lung cancer. In low-income countries, cervical cancer is the second most common fatal malignant tumor . Evidently, cervical cancer causes a substantial burden on women’s public health globally. Cervical cancer incidence and mortality rates in the United States have substantially declined over recent decades, primarily driven by reductions in squamous cell carcinoma cases. However, the trend in recent years remains unclear.
This study was aimed to explore the trends in cervical cancer incidence, prevalence and mortality, stratified by demographic, particularly age- related incidence, death rates, rural and urban population, screening programme and tumor characteristics from 2000 to 2030 in India, in Global context.
Among the selected countries, India exhibited the lowest incidence and mortality rates for all-cause cancer among women, with rates of 100.83 and 62.61 per 100,000 person-years, respectively. However, the ASIR and ASMR of cervical cancer were the second highest in India (17.71 and 11.15 per 100,000 person-years) after South Africa (33.18 and 19.03 per 100,000 person-years). The incidence rates in India are below the global median for all cancers (157.66), breast cancer (46.21), and corpus uteri cancer (7.03), but they are above the global median for cervix uteri cancer (14.10). A similar trend was observed concerning cancer-related mortality rates among Indian women. Nearly 54% of cancer incidence and 50% of cancer mortality among women in India are attributed to these six female-specific cancers.
Conclusions: India contributed significantly to the global burden of female-specific cancers, the ASIR and ASMR for these cancers were lower than those in many other countries. It was essential to study how sociodemographic transitions influenced the patterns of female-specific cervical cancer in high, low, and middle-income countries to inform the implementation of effective cancer control strategies by health systems in India as compared to other countries.
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Olusola P, Banerjee HN, Philley JV, Dasgupta S. Human papilloma virus-associated cervical Cancer and health disparities. Cells. (2019) 8:622.
Sundstrom K, Elfstrom KM. Advances in cervical Cancer prevention: efficacy, effectiveness, elimination? PLoS Med. (2020) 17:e1003035.
Lin S, Gao K, Gu S, You L, Qian S, Tang M, et al. Worldwide trends in cervical Cancer incidence and mortality, with predictions for the next 15 years. Cancer. (2021) 127:4030–9.
Yu-yi Ou , Zi-Jun Lin , Santosh Chokkakula , Siomui Chong , Xiaohua Xu Liying Huang , Andrew In-Cheong , Jiang Yong Chengliang Yin, Jun Lyu, Xiao-bin Huang. Trends in cervical cancer incidence in the United States from 2000-2019.Clinical Epidemiology and Global Health.2025; 33: 102002
Singh D, Vignat J, Lorenzoni V, Eslahi M, Ginsburg O, Lauby-Secretan B, et al. Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Glob Health. 2023;11(2):e197–206.
Zhang X, Zeng Q, Cai W, Ruan W. Trends of cervical cancer at global, regional, and national level: data from the Global Burden of Disease study 2019. BMC Public Health. 2021;21(1):894.
Kulothungan V, Ramamoorthy T, Mohan R, Mathur P. Assessing progress of India in reduction of premature mortality due to four noncom municable diseases towards achieving the WHO 25_25 goal and the sustainable development goals. Sustainable Development. 2023;1–11.
Singh M, Jha RP, Shri N, Bhattacharyya K, Patel P, Dhamnetiya D, et al. Secular trends in incidence and mortality of cervical cancer in India and its states, 1990–2019: data from the Global Burden of Disease 2019 Study. BMC Cancer. 2022;22(1):149.
Bhatla N, Meena J, Kumari S, Banerjee D, Singh P, Natarajan J, et al. Cervical cancer prevention efforts in India. Indian J Gynecol Oncol. 2021;19(3):41.
Banerjee B. National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS). In: DK Taneja’s Health Policies and Programmes in India. Jaypee Brothers Medical Publishers (P) Ltd.; 2017. p. 429–429.
International Institute for Population Sciences (IIPS) and ICF. 2021. National Family Health Survey (NFHS-5), 2019–21: India: Volume 2022.
World Health Organization. Draft: global strategy towards the elimination of cervical cancer as a public health problem.2019. Available from: https://www.who.int/publications/m/item/draft-global-strategy-towar ds-eliminating-cervical-cancer-as-a-public-health-problem. Cited: 2022 Mar 5.
Singh MP, Chauhan AS, Rai B, Ghoshal S, Prinja S. Cost of treatment for cervical cancer in India. Asian Pac J Cancer Prev. 2020;21(9):2639–46.
Kulothungan V, Sathishkumar K, Leburu S, Ramamoorthy T, Stephen S, Basavarajappa D, et al. Burden of cancers in India - estimates of cancer crude incidence, YLLs, YLDs and DALYs for 2021 and 2025 based on National Cancer Registry Program. BMC Cancer. 2022;22(1):527.
Kulothungan V, Ramamoorthy T, Sathishkumar K, et al. Burden of female breast cancer in India: estimates of YLDs, YLLs, and DALYs at national and subnational levels based on the national cancer registry programme. Breast Cancer Res Treat. 2024.
Dhillon PK, Mathur P, Nandakumar A, Fitzmaurice C, Kumar GA, Mehrotra R, et al. The burden of cancers and their variations across the states of India: the Global Burden of Disease Study 1990–2016. Lancet Oncol. 2018;19(10):1289–306.
Office of the Registrar General & Census Commissioner, India. Ministry of Home Affairs, Government of India. Available from: https://censusindia. gov.in/. Cited 2023 Mar 14.
Office of the Registrar General & Census Commissioner, India. Ministry ofHome Affairs, Government of India. SRS Statistical Report. Availablehttps://censusindia.gov.in/vital_statistics/SRS_Statistical_Report.html. Cited 2023 Mar 27.
Institute for Health Metrics and Evaluation (IHME). Global Burden of Disease Study 2019 (GBD 2019) Disability Weights. 2020. https://doi.org/ 10.6069/1W19-VX76. Cited 2023 Mar 14.
Global Data Lab. Sub-national HDI (v5.0). Available from: https://globaldatalab.org/shdi/table/shdi/IND/?levels=1+4&years=2019&extrapolation=0. Cited 2022 Dec 10.
Ramamoorthy T, Leburu S, Kulothungan V, Mathur P. Regional estimates of noncommunicable diseases associated risk factors among adults in India: results from National Noncommunicable Disease Monitoring Survey. BMC Public Health. 2022;22:1069.
Seenappa K, Kulothungan V, Mohan R, Mathur P. District-Wise Heterogeneity in Blood Pressure Measurements, Prehypertension, Raised Blood Pressure, and Their Determinants Among Indians: National Family Health Survey-5. Int J Public Health. 2024;69. https://doi.org/10.3389/ijph.2024. 1606766
Soerjomataram I, Bray F. Planning for tomorrow: global cancer incidence and the role of prevention 2020–2070. Nat Rev Clin Oncol. 2021;18(10):663–72.
Dhillon PK, Yeole BB, Dikshit R, Kurkure AP, Bray F. Trends in breast, ovarian and cervical cancer incidence in Mumbai, India over a 30-year period, 1976–2005: an age–period–cohort analysis. Br J Cancer. 2011;105(5):723–30.
Sreedevi A, Javed R, Dinesh A. Epidemiology of cervical cancer with special focus on India. Int J Women’s Health. 2015;7:405–14.
Department of Health and Family Welfare. Ministry of Health and Family Welfare, Government of India. Annual Report 2015–16.2016. Available: https://main.mohfw.gov.in/sites/default/files/563256321456689 65478.pdf. Cited 2023 Mar 3.
National AIDS Control Organisation. Ministry of Health & Family Welfare. Government of India. HIV Facts & Figures. Available from: http://naco.gov.in/hiv-facts-figures. Cited 2022 Dec 6.
Ramamoorthy T, Sathishkumar K, Das P, Sudarshan KL, Mathur P. Epidemiology of human papillomavirus related cancers in India: findings from the National Cancer Registry Programme. Ecancermedicalscience. 2022;7(16):1444.
Sathishkumar K, Vinodh N, Badwe RA, Deo SVS, Manoharan N, Malik R, et al. Trends in breast and cervical cancer in India under National Cancer Registry Programme: An Age-Period-Cohort analysis. Cancer Epidemiol. 2021;74:101982.
Man I, Georges D, de Carvalho TM, Ray Saraswati L, Bhandari P, Kataria I, et al. Evidence-based impact projections of single-dose human papillomavirus vaccination in India: a modelling study. Lancet Oncol. 2022;23(11):1419–29.
Press Information Bureau. Government of India. Centre urges States to create awareness and take steps for prevention of cervical cancer among girl students. Available from: https://pib.gov.in/PressReleseDetailm.aspx? PRID=1885597. Cited 2023 Feb 22.
Indian Council of Medical Research – National Centre for Disease Informatics and Research. Report of National Cancer Registry Programme (2012–2016).2020. Available from: https://www.ncdirindia.org/All_Reports/Report_2020/resources/NCRP_2020_2012_16.pdf. Cited 2023 Mar 27.
Sathishkumar K, Chaturvedi M, Das P, Stephen S, Mathur P. Cancer incidence estimates for 2022 & projection for 2025: Result from National Cancer Registry Programme, India. Indian J Med Res. 2022;156(4&5):598–607.
Chaturvedi M, Sathishkumar K, Lakshminarayana SK, Nath A, Das P, Mathur P. Women cancers in India: Incidence, trends and their clinical extent from the National Cancer Registry Programme. Cancer Epidemiol. 2022;80:102248.
Ortiz AP, Ortiz-Ortiz KJ, Colon-Lopez V, Tortolero-Luna G, Torres-Cintron CR, Wu CF, et al. Incidence of cervical Cancer in Puerto Rico, 2001-2017. JAMA Oncol. (2021) 7:456–8.
World Health Organisation. WHO methods and data sources for global burden of disease estimates 2000 – 2019.2020. Available from:://cdn.who.int/media/docs/default-source/gho-documents/global healthestimates/ghe2019_daly-methods.pdf. Cited 2023 Mar 14.
Kumar GA, Dandona L, Dandona R. Completeness of death registration in the Civil Registration System, India (2005 to 2015). Indian J Med Res. 2019;149(6):740–7.
Brisson M, Kim JJ, Canfell K, Drolet M, Gingras G, Burger EA, et al. Impact of HPV vaccination and cervical screening on cervical cancer elimination: a comparative modelling analysis in 78 low-income and lower-middleincome countries. Lancet. 2020;395(10224):575–90.
Sathishkumar K, Sankarapillai J, Mathew A , Nair R A, Gangane N, Khuraijam S, et al. Survival of patients with cervical cancer in India – findings from 11 population based cancer registries under National Cancer Registry Programme. Lancet Regional Health Southeast Asia. 2023;100296.
National Cancer Institute, Surveillance, Epidemiology, End Results Program. Seer*Stat Database: Incidence-Based Mortality—Seer 9 Regs Research Data. Nov 2020 sub (1975-2018) —linked to county attributes— Total us, 1969-2019 counties National Cancer Institute, Dccps, Surveillance Research Program. SEER database (2021).(10167):169–182.
Viale PH. The American Cancer Society’s Facts & Figures: 2020 Edition. DOI: 10.6004/jadpro.2020.11.2.1.
Castle PE. Looking back, moving forward: challenges and opportunities for global cervical cancer prevention and control. Viruses. 2024 Aug 25;16(9):1357.
White JL, Grabowski MK, Rositch AF, et al. Trends in adolescent human papillomavirus vaccination and parental hesitancy in the United States. J Infect Dis. 2023;228(5):615–626.
Korn AR, Walsh-Bailey C, Correa-Mendez M, et al. Social determinants of health and US cancer screening interventions: a systematic review. CA Cancer J Clin. 2023;73 (5):461–479.
Losada C, Samaha H, Scherer EM, et al. Efficacy and durability of immune response after receipt of HPV vaccines in people living with HIV. Vaccines. 2023;11(6):1067.
World Health Organization (2022) Cancer (Geneva: World Health Organization) [https://www.who.int/news-room/fact-sheets/detail/ cancer#:~:text=Key%20facts,and%20rectum%20and%20prostate%20cancers] Date accessed: 24/04/24
Global Cancer Observatory (2024) Cancer today [https://gco.iarc.who.int/today] Date accessed: 19/04/24
ICMR-NCDIR (2020) Report of National cancer registry programme [https://www.ncdirindia.org/All_Reports/Report_2020/default. aspx] Date accessed: 13/06/24
Bray F, Colombet M, and Aitken JF, et al (2023) Cancer incidence in five continents, Vol. XII (IARC CancerBase No 19) [https://ci5.iarc. who.int] Date accessed: 17/06/24
Government of India (2011) States census 2011 [https://www.census2011.co.in/states.php] Date accessed: 19/04/24
Ministry of Health and Family Welfare, Government of India (2023) Measures to check rising cases of cancers [https://pib.gov.in/Press ReleasePage.aspx?PRID=1943656] Date accessed: 19/04/24
Budukh A, Khanna D, and Bagal S, et al (2022) Cancer Incidence and Mortality in Varanasi District, Uttar Pradesh, India: 2018-2019 – Population-Based Cancer Registry Report [https://tmc.gov.in/tmh/pdf/Reports/Varanasi%20PBCR%20Detail%20report%20%202018-2019. pdf] Date accessed: 24/04/24
Ministry of Health and Family Welfare, Government of India (2024) National Programme for prevention and control of cancer, diabetes, cardiovascular diseases and stroke [https://nhm.gov.in/index1.php?lang=1&level=2&sublinkid=1048&lid=604] Date accessed: 13/06/24
Ministry of Health and Family Welfare, Government of India (2016) Operational Framework- Management of Common Cancers [https:// nhsrcindia.org/sites/default/files/202103/Operational%20Framework%20Management%20of%20Common%20Cancers.pdf] Date accessed: 24/04/24
Ministry of Health and Family Welfare, Government of India (2016) Module for Multi-Purpose Workers (MPW) – Female/Male on Prevention, Screening and Control of Common Non-Communicable Diseases [https://main.mohfw.gov.in/sites/default/files/Module%20for%20Multi-Purpose%20Workers%20%20Prevention%2C%20Screening%20and%20Control%20of%20Common%20NCDS_2
Ministry of Health and Family Welfare, Government of India (2021) National family health survey (NFHS-5) 2019-2021 [http://rchiips. org/nfhs/factsheet_NFHS-5.shtml] Date accessed: 24/04/24
Patel KK, Chakravarti P, and Chaturvedi P, et al (2022) The fifth round of the National family health survey of India 2019 to 2021 reported low screening uptake alarming to strengthen the implementation of early detection services of the cervix, breast and oral cancer Int J Cancer 150 1734–1736
Basu P, Sarkar S, and Mukherjee S, et al (2006) Women's perceptions and social barriers determine compliance to cervical screening: results from a population based study in India Cancer Detect Prev 30 369–374
International Agency for Research on Cancer (IARC) (2022) Cervical cancer screening IARC Handb Cancer Prev 18 1–456
International Institute for Population Sciences (IIPS) (2019) National Family Health Survey (NFHS-5) Clinical, Anthropometric and Biochemical (CAB) Manual 2019-2020 [https://rchiips.org/NFHS/NFHS5/manuals/NFHS-5%20CAB%20Manual_Eng.pdf] Date accessed: 13/06/24
Priyal Chakravarti, Kamalesh Kumar Patel, Atul Budukh, Divya Khanna, Pankaj Chaturvedi, Satyajit Pradhan, Rajesh Dikshit and Rajendra Badwe.Cancer screening uptake by women from India’s largest state Uttar Pradesh: district-wise analysis from the fifth round of National Family Health Survey (2019–2021). ecancer 2024; 18:1742
Wirtz C, Mohamed Y, Engel D, et al. Integrating HPV vaccination programs with enhanced cervical cancer screening and treatment, a systematic review. Vaccine.2022;40(Suppl 1):A116–A123
Mix JM, Van Dyne EA, Saraiya M, Hallowell BD, Thomas CC. Assessing impact of HPV vaccination on cervical cancer incidence among women aged 15-29 Years in the United States, 1999-2017: an ecologic study. Cancer Epidemiol Biomarkers Prev. 2021 Jan;30(1):30–37. Yao H, Yan C, Qiumin H, et al. Epidemiological trends and attributable risk burden of cervical cancer: an observational study from 1990 to 2019. Int J Clin Pract. 2022 Sep 30;2022, 3356431.
Liu G, Yang Z, Wang C, Wang D. PM2.5 exposure and cervical cancer survival in Liaoning Province, northeastern China. Environ Sci Pollut Res Int. 2022;29(49): 74669–74676.
Ramamoorthy T, Kulothungan V, Sathishkumar K , Tomy N , Mohan R , Balan S and Mathur P. Burden of cervical cancer in India: estimates of years of life lost, years lived with disability and disability adjusted life years at national and subnational levels using the National Cancer Registry Programme data.Reproductive Health, 2024; 21:111
Kim D, Lee H, Kim M. Overview of human papillomavirus vaccination policy changes and its impact in the United States: lessons learned and challenges for the future. Public Health Nurs Boston Mass. 2021;38(3):396–405.
Ponduri A, Azmy MC, Axler E, et al. The efficacy of human papillomavirus vaccination as an adjuvant therapy in recurrent respiratory papillomatosis. Laryngoscope. 2023;133(9):2046–2054.
Benard VB, Watson M, Saraiya M, et al. Cervical cancer survival in the United States by race and stage (2001-2009): findings from the CONCORD-2 study. Cancer. 2017 Dec 15;123(Suppl 24):5119–5137.
Islami F, Fedewa SA, Jemal A. Trends in cervical cancer incidence rates by age, race/ ethnicity, histological subtype, and stage at diagnosis in the United States. Prev Med. 2019 Jun 1;123:316–323.
Guo F, Cofie LE, Berenson AB. Cervical cancer incidence in young US females after human papillomavirus vaccine introduction. Am J Prev Med. 2018 Aug 1;55(2): 197–204.
Moon EK, Oh CM, Won YJ, et al. Trends and age-period-cohort effects on the incidence and mortality rate of cervical cancer in Korea. Cancer research and treatment: official journal of Korean Cancer Association. 2017 Apr 1;49(2):526–533.
Lei J, Ploner A, Elfstrom ¨ KM, et al. HPV vaccination and the risk of invasive cervical cancer. N Engl J Med. 2020 Oct 1;383(14):1340–1348.
Li Y, Che W, Yu Z, et al. The Incidence Trend of Papillary Thyroid Carcinoma in the United States during 2003-201729. Cancer Control J Moffitt Cancer Cent; 2022.
Yang J, Li Y, Liu Q, et al. Brief introduction of medical database and data mining technology in big data era. J Evid Base Med. 2020;13(1):57- 69.
Wu WT, Li YJ, Feng AZ, et al. Data mining in clinical big data: the frequently used databases, steps, and methodological models. Mil Med Res. 2021;8(1):44.
Che W, Liu J, Fu T, Wang X, Lyu J. Recent trends in synchronous brain metastasis incidence and mortality in the United States: ten-year multicenter experience. Curr Oncol. 2022.
Torres-Roman JS, Ronceros-Cardenas L, Valcarcel B, et al. Cervical cancer mortality among young women in Latin America and the Caribbean: trend analysis from 1997 to 2030. BMC Public Health. 2022 Jan 16;22(1):113.
Tu YK, Kramer ¨ N, Lee WC. Addressing the identification problem in Age-periodcohort analysis: a tutorial on the use of partial least squares and principal components analysis. Epidemiology. 2012;23(4):583–593.
Torre LA, Siegel RL, Ward EM, Jemal A. Global cancer incidence and mortality rates and trends–an update. Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):16–27.
Fera AND, Warburton A, Coursey TL, Khurana S, McBride AA. Persistent Human Papillomavirus Infection. 2021.
Li M, Wang D, Huang J, Luan S, Wang Q. Sexual behaviors and intimate relationships of sexual partners of young patients with early-stage cervical cancer: a qualitative study. Int J Gen Med. 2023;16:5377–5387.
Pimple S, Mishra G. Cancer cervix: epidemiology and disease burden. CytoJournal. 2022 Mar 29;19:21.
Maldonado I, Plata M, Gonzalez M, et al. Effectiveness, immunogenicity, and safety of the quadrivalent HPV vaccine in women and men aged 27-45 years. Hum Vaccines Immunother. 2022;18(5), 2078626.
Kessler TA. Cervical cancer: prevention and early detection. Semin Oncol Nurs. 2017; 33(2):172–183.
Fowler CI, Saraiya M, Moskosky SB, Miller JW, Gable J, Mautone-Smith N. Trends in cervical cancer screening in title X-funded health centers. United States. 2017;66 (37). 5.
Davies-Oliveira JC, Smith MA, Grover S, Canfell K, Crosbie EJ. Eliminating cervical cancer: progress and challenges for high-income countries. Clin Oncol R Coll Radiol G B. 2021;33(9):550–559.
Aljakouch K, Hilal Z, Daho I, et al. Fast and noninvasive diagnosis of cervical cancer by coherent anti-Stokes Raman scattering. Anal Chem. 2019;91(21):13900–13906.
Watson M, Soman A, Flagg EW, et al. Surveillance of high-grade cervical cancer precursors (CIN III/AIS) in four population-based cancer registries, United States, 2009–2012. Prev Med. 2017;103:60–65.
Champion VL, Paskett ED, Stump TE, et al. Comparative effectiveness of 2 interventions to increase breast, cervical, and colorectal cancer screening among women in the rural US: a randomized clinical trial. JAMA Netw Open. 2023;6(4), e2311004.
Jonnada PK, Sushma C, KaryampudiM, Dharanikota A. Prevalence of molecular subtypes of breast cancer in India: a systematic review and meta-analysis. Indian J Surg Oncol 2021;12(suppl 1):152–163
Ali I, Wani WA, Saleem K. Cancer scenario in India with future perspectives. Cancer Ther 2011;8:56–70
Srinath Reddy K, Shah B, Varghese C, Ramadoss A. Responding to the threat of chronic diseases in India. Lancet 2005;366(9498): 1744–1749
93. Mathur P, Sathishkumar K, Chaturvedi M, et al; ICMR-NCDIRNCRP Investigator Group. Cancer Statistics, 2020: report from National Cancer Registry Programme, India. JCO Glob Oncol 2020; 6(06):1063–1075
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015;65(02):87–108
Time Trends in Cancer Incidence Rates 1982–2010. Accessed December 23, 2024 at: https://www.ncdirindia.org/All_Reports/ TREND_REPORT_1982_2010/
Balasubramaniam SM, Rotti SB, Vivekanandam S. Risk factors of female breast carcinoma: a case control study at Puducherry. Indian J Cancer 2013;50(01):65–70
Chopra B, Kaur V, Singh K, Verma M, Singh S, Singh A. Age shift: breast cancer is occurring in younger age groups - Is it true? Clin Cancer Investig J 2014;3(06):526–529
Kakarala M, Rozek L, Cote M, Liyanage S, Brenner DE. Breast cancer histology and receptor status characterization in Asian Indian and Pakistani women in the U.S.–a SEER analysis. BMC Cancer 2010; 10:191
Boyle P, Parkin, D.M. Statistical methods for registries. In D.M. Parkin, C. S. Muir, S. L.Whelan, Y. T.Gao, J. Ferlay, J. Powell, (Eds.), Cancer Incidence in Five Continents, Volume VI. IARC Scientific Publications No. 120:126–158
Bray F, Znaor A, Cueva P, et al. Planning and Developing Population-Based Cancer Registration in Low- or Middle-Income Settings. Lyon, France: International Agency for Research on Cancer; 2014
Vemula S and Dhakshanamoorthy K.Epidemiology of Cancer Incidence Estimates and Statistics 2000–2025: Analysis from National Cancer Registry Programme in India. Ind J Med Paediatr Oncol. 2025;46:278–287.
Dhar M. A critical review of evolution of cancer registration in India. J Tumor Med Prev 2018;2(04):555594
Sahoo S, Verma M, Parija P. An overview of cancer registration in India: present status and future challenges. Oncol J India 2018;2 (04):86
Behera P, Patro BK. Population Based Cancer Registry of India – the challenges and opportunities. Asian Pac J Cancer Prev 2018;19 (10):2885–2889
Murthy NS, Chaudhry K, Rath GK. Burden of cancer and projections for 2016, Indian scenario: gaps in the availability of radiotherapy treatment facilities. Asian Pac J Cancer Prev 2008;9(04): 671–677
Swaminathan R, Shanta V, Ferlay J, Balasubramanian S, Bray F, Sankaranarayanan R. Trends in cancer incidence in Chennai city (1982–2006) and statewide predictions of future burden in Tamil Nadu (2007–16). Natl Med J India 2011;24(02):72–77
Takiar R, Nadayil D, Nandakumar A. Projections of number of cancer cases in India (2010-2020) by cancer groups. Asian Pac J Cancer Prev 2010;11(04):1045–1049
D’Souza NDR, Murthy NS, Aras RY. Projection of cancer incident cases for India -till 2026. Asian Pac J Cancer Prev 2013;14(07): 4379–4386
Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 2006;24(14):2137–2150
Sun P, Yu C, Yin L, Chen Y, Sun Z, Zhang T, et al. Global, regional, and national burden of female cancers in women of childbearing age, 1990–2021: analysis of data from the global burden of disease study 2021. eClinicalMedicine. 2024; 74: 102713.
Priyadarshini S, Swain PK, Agarwal K, Jena D, Padhee S. Trends in gynecological cancer incidence, mortality, and survival among elderly women: A SEER study. Aging Medicine. 2024; 7: 179–188.
Rajappa S, Singh M, Uehara R, Schachterle SE, Setia S. Cancer incidence and mortality trends in Asia based on regions and human development index levels: an analyses from GLOBOCAN 2020. Current Medical Research and Opinion. 2023; 39: 1127–1137.
Wang J, Lv H, Xue Z, Wang L, Bai Z. Temporal Trends of Common Female Malignances on Breast, Cervical, and Ovarian Cancer Mortality in Japan, Republic of Korea, and Singapore: Application of the Age-Period-Cohort Model. BioMed Research International. 2018; 2018: 5307459.
Zhu B, Gu H, Mao Z, Beeraka NM, Zhao X, Anand MP, et al. Global burden of gynaecological cancers in 2022 and projections to 2050. Journal of Global Health. 2024; 14: 04155.
Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the cervix uteri: 2021 update. International Journal of Gynaecology and Obstetrics. 2021; 155: 28–44.
Cancer (IARC) TIA for R on. Global Cancer Observatory. 2024. Available at: https://gco.iarc.fr/ (Accessed: 22 August 2024).
Gopika MG, Prabhu PR, Thulaseedharan JV. Status of cancer screening in India: An alarm signal from the National Family Health Survey (NFHS-5). Journal of Family Medicine and Primary Care. 2022; 11: 7303–7307.
Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A, et al. Cancer statistics for the year 2020: An overview. International Journal of Cancer. 2021. c.33588.
Sun K, Han B, Zeng H, Wang S, Li L, Chen R, et al. Incidence and Mortality of Cancers in Female Genital Organs - China, 2022. China CDC Weekly. 2024; 6: 195–202..
Tan N, Wu Y, Li B, Chen W. Burden of female breast and five gynecological cancers in China and worldwide. Chinese Medical Journal. 2024; 137: 2190–2201.
VinodaThulaseedharan J. Evaluation of Sociodemographic, Reproductive and Screening-related Factors on Risk of and Survival from Cervical Cancer in Rural South India. Tampere University Press:Tampere. 2017.
Australian Institute of Health and Welfare. Cancer data in Australia, Overview of cancer in Australia. 2024. Available at: https://www.aihw.gov.au/reports/cancer/cancer-data-in-aus tralia/contents/overview (Accessed: 22 August 2024).
Xu S, Murtagh S, Han Y, Wan F, Toriola AT. Breast Cancer Incidence Among US Women Aged 20 to 49 Years by Race, Stage, and Hormone Receptor Status. JAMA Network Open. 2024; 7: e2353331.
Maza M, Alfaro K, Garai J, Velado MM, Gage JC, Castle PE, et al. Cervical cancer prevention in El Salvador (CAPE)-An HPV testing-based demonstration project: Changing the secondary prevention paradigm in a lower middle-income country. Gynecologic Oncology Reports. 2017; 20: 58–61
Di Sibio A, Abriata G, Forman D, Sierra MS. Female breast cancer in Central and South America. Cancer Epidemiology. 2016; 44: S110–S120.
Gregory J, Foster L, O’Shaughnessy P, Robson SJ. The socioeconomic gradient in mortality from ovarian, cervical, and endometrial cancer in Australian women, 2001–2018: A population-based study. The Australian & New Zealand Journal of Obstetrics & Gynaecology. 2022; 62: 714–719.
Li S, He Y, Liu J, Chen K, Yang Y, Tao K, et al. An umbrella review of socioeconomic status and cancer. Nature Communications. 2024; 15: 9993.
Ayubi E, Lyus R, Brhlikova P, Pollock AM. A critical appraisal of the quality of data submitted by subSaharan African cancer registries to GLOBOCAN 2020. JRSM Open. 2024; 15: 20542704231217888.
Antoni S, Soerjomataram I, Møller B, Bray F, Ferlay J. An assessment of GLOBOCAN methods for deriving national estimates of cancer incidence. Bulletin of the World Health Organization. 2016; 94: 174–184.
Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer 2019;144(08):1941–1953
Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J (Engl) 2022;135(05):584–590
Kakkar R, Aggarwal P. Civil registration and sample registration system: challenges and initiatives. SRHU Med J 2017;1(01):47–49
Porter PL. Global trends in breast cancer incidence and mortality. Salud Publica Mex 2009;51(suppl 2):s141–s146
Kishore S, Kiran K. Cancer scenario in India and its comparison with rest of the world and future perspectives. Indian J Community Health 2019;31(01):1–3 Indian Journal of Medical and Paediatric Oncology Vol. 46
Chelimo C, Wouldes TA, Cameron LD, Elwood JM. Risk factors for and prevention of human papillomaviruses (Hpv), genital warts and cervical Cancer. J Infect. (2013) 66:207–17.
Au WW, Abdou-Salama S, Sierra-Torres CH, Al-Hendy A. Environmental risk factors for prevention and molecular intervention of cervical Cancer. Int J Hyg Environ Health. (2007) 210:671–8.
Stanley M. Pathology and epidemiology of Hpv infection in females. Gynecol Oncol. (2010) 117:S5–S10.
Goodman A. Hpv testing as a screen for cervical Cancer. BMJ. (2015) 350:h 2372. Bhatla N, Singhal S. Primary Hpv screening for cervical Cancer. Best Pract Res Clin Obstet Gynaecol. 2020; 65:98–108.
Kumari P, Kumar M, Reddy CR, Jha B. Nitrate and phosphate regimes induced Lipidomic and biochemical changes in the intertidal macroalga Ulva lactuca (Ulvophyceae, Chlorophyta). Plant Cell Physiol. (2014) 55:52–63.
Gien LT, Beauchemin MC, Thomas G. Adenocarcinoma: A Unique Cervical Cancer. Gynecol Oncol. (2010) 116:140–6.
Park KJ. Cervical adenocarcinoma: integration of Hpv status, pattern of invasion, morphology and molecular markers into classification. Histopathology. (2020) 76:112–27.
Harro CD, Pang YY, Roden RB, Hildesheim A, Wang Z, Reynolds MJ, et al. Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. J Natl Cancer Inst. (2001) 93:284–92.
Ault K, Reisinger K. Programmatic issues in the implementation of an Hpv vaccination program to prevent cervical Cancer. Int J Infect Dis. 2007; 11:S26–8.
Gallagher KE, LaMontagne DS, Watson-Jones D. Status of Hpv vaccine introduction and barriers to country uptake. Vaccine. (2018) 36:4761–7.
Printz C. Lower cervical Cancer risk associated with Hpv vaccine. Cancer. (2021) 127:1171.
Stelzle D, Tanaka LF, Lee KK, Ibrahim Khalil A, Baussano I, Shah ASV, et al. Estimates of the global burden of cervical Cancer associated with Hiv. Lancet Glob Health. 2021; 9:e161–9.
Liu G, Sharma M, Tan N, Barnabas RV. Hiv-positive women have higher risk of human papilloma virus infection, precancerous lesions, and cervical Cancer. AIDS. 2018; 32:795–808.
Humans IWGotEoCRt. Biological agents. Volume 100 B. A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum. 2012; 100:1–441.
Dryden-Peterson S, Bvochora-Nsingo M, Suneja G, Efstathiou JA, Grover S, Chiyapo S, et al. Hiv infection and survival among women with cervical Cancer. J Clin Oncol. 2016; 34:3749–57.
Yang M, Du J, Lu H, Xiang F, Mei H, Xiao H. Global trends and age-specific incidence and mortality of cervical cancer from 1990 to 2019: an international comparative study based on the global burden of disease. BMJ Open. 2022; 12:e055470.
Zhang S, Li Q, Ouyang X, Tang Y, Cui J, Yang Z. Radiotherapy can improve overall survival in patients with lymph-node positive, high-grade neuroendocrine cervical cancer: construction of two prognostic nomograms to predict treatment outcome. Front Oncol. 2024; 14:1450382.
Fan X, He W, Zhang Q, Zhang B, Dong L, Li L, et al. Evaluation and prediction analysis of 3- and 5-year relative survival rates of patients with cervical Cancer: a modelbased period analysis. Cancer Control. 2024; 31:10732748241232324.
Tran KN, Park Y, Kim BW, Oh JK, Ki M. Incidence and mortality of cervical Cancer in Vietnam and Korea (1999-2017). Epidemiol Health. (2020) 42:e2020075.
Hansen BT, Campbell S, Nygard M. Regional differences in cervical Cancer incidence and associated risk behaviors among Norwegian women: a population-based study. BMC Cancer. 2021; 21:935.
Cheng X, Wang P, Cheng L, Zhao F and Liu J. Trends in cervical cancer incidence and mortality in the United States, 1975–2018: a population-based study. Front. Med. 2025; 12:1579446.
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