Advanced Chromatographic Techniques For Pesticide Determination In Biological Specimens: Precision Approaches In Analytical Toxicology
Keywords:
Chromatography, Pesticide, Biological Samples, Toxicology, InnovationAbstract
Pesticides are crucial in preventing vector-borne diseases, protecting crops, and preserving food, thus playing a noteworthy role in sustaining global food production. The use of pesticides is expected to increase substantially, with projections indicating a rise to nearly 10 billion metric tons by 2050. Despite their benefits, pesticides raise concerns because of their potential effects on human health and the environment. Only around 1% of applied pesticides effectively reach the targeted pests, whereas the remaining 99% disperse into soil, water, and surrounding ecosystems, affecting non-target organisms. This widespread contamination has been associated with severe health risks, especially for agricultural workers and vulnerable populations like children. Chronic pesticide exposure often raises the threat of cancers, neurological disorders, and respiratory issues. Environmentally, pesticides harm biodiversity, degrade soil health, and cause a decline in pollinator populations, which are vital to ecosystem balance. To monitor and mitigate these risks, advanced chromatography techniques, particularly gas chromatography-mass spectrometry (GC-MS), liquid chromatography-tandem mass spectrometry (LC-MS/MS), and UHPLC-MS are widely used for the detection of pesticide residues in biological specimens, including blood and urine. These advanced techniques offer high sensitivity, specificity, and precision, making them essential for assessing human exposure, supporting public health studies, and meeting regulatory standards. This review delves into the complexities of pesticide exposure, recent advancements in chromatographic detection, and emerging strategies in residue analysis, emphasizing the need for ongoing innovation to enhance pesticide monitoring and safeguard the health and the environment
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Sharma A, Kumar V, Shahzad B, Tanveer M, Sidhu GPS, Handa N, et al. Worldwide pesticide usage and its impacts on ecosystem. SN Appl Sci. 2019 Nov;1(11):1446.
Zhan H, Huang Y, Lin Z, Bhatt P, Chen S. New insights into the microbial degradation and catalytic mechanism of synthetic pyrethroids. Environ Res. 2020 Mar;182:109138.
Bhatt P, Joshi T, Bhatt K, Zhang W, Huang Y, Chen S. Binding interaction of glyphosate with glyphosate oxidoreductase and C–P lyase: Molecular docking and molecular dynamics simulation studies. J Hazard Mater. 2021 May;409:124927.
Bernardes MFF, Pazin M, Pereira LC, Dorta DJ. Impact of Pesticides on Environmental and Human Health. In: Andreazza AC, Scola G, editors. Toxicology Studies - Cells, Drugs and Environment [Internet]. InTech; 2015 [cited 2024 Oct 26]. Available from: http://www.intechopen.com/books/toxicology-studies-cells-drugs-and-environment/impact-of-pesticides-on-environmental-and-human-health
Strassemeyer J, Daehmlow D, Dominic AR, Lorenz S, Golla B. SYNOPS-WEB, an online tool for environmental risk assessment to evaluate pesticide strategies on field level. Crop Prot. 2017 Jul;97:28–44.
Tudi M, Daniel Ruan H, Wang L, Lyu J, Sadler R, Connell D, et al. Agriculture Development, Pesticide Application and Its Impact on the Environment. Int J Environ Res Public Health. 2021 Jan 27;18(3):1112.
Fernández‐López MG, Popoca‐Ursino C, Sánchez‐Salinas E, Tinoco‐Valencia R, Folch‐Mallol JL, Dantán‐González E, et al. Enhancing methyl parathion degradation by the immobilization of Burkholderia sp. isolated from agricultural soils. MicrobiologyOpen. 2017 Oct;6(5):e00507.
Hayes TB, Hansen M. From silent spring to silent night: Agrochemicals and the anthropocene. Kapuscinski AR, Locke KA, Barnosky A, editors. Elem Sci Anthr. 2017 Jan 1;5:57.
Hernández AF, Gil F, Lacasaña M, Rodríguez-Barranco M, Tsatsakis AM, Requena M, et al. Pesticide exposure and genetic variation in xenobiotic-metabolizing enzymes interact to induce biochemical liver damage. Food Chem Toxicol. 2013 Nov;61:144–51.
Forecast agricultural consumption of pesticides worldwide from 2023 to 2027(in 1,000 metric tons). Available from: https://www.statista.com/statistics/1401556/global-agricultural-use-of-pesticides forecast/#:~:text=Forecast%3A%20global%20agricultural%20use%20of%20pesticides%202023%2D2027&text=The%20worldwide%20agricultural%20consumption%20of,million%20metric%20tons%20in%202027.
Carvalho FP. Pesticides, environment, and food safety. Food Energy Secur. 2017 May;6(2):48–60.
Bhandari S, Paneru S, Pandit S, Rijal S, Manandhar HK, Ghimire BP. Assessment of pesticide use in major vegetables from farmers’ perception and knowledge in Dhading district, Nepal. J Agric Nat Resour. 2020 Jan 8;3(1):265–81.
Kaur R, Mavi GK, Raghav S, Khan I. Pesticides Classification and its Impact on Environment. Int J Curr Microbiol Appl Sci. 2019 Mar 20;8(03):1889–97.
Karunarathne A, Gunnell D, Konradsen F, Eddleston M. How many premature deaths from pesticide suicide have occurred since the agricultural Green Revolution? Clin Toxicol. 2020 Apr 2;58(4):227–32.
Poudel S, Poudel B, Acharya B, Poudel P. Pesticide Use And Its Impacts On Human Health And Environment. Environ Ecosyst Sci. 2020 Oct 5;4(1):47–51.
Tarazona JV, Court-Marques D, Tiramani M, Reich H, Pfeil R, Istace F, et al. Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC. Arch Toxicol. 2017 Aug;91(8):2723–43.
Ghosh A, Tripathy A, Ghosh D. Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human. Proc Zool Soc. 2022 Mar;75(1):16–30.
Tsai YH, Lein PJ. Mechanisms of organophosphate neurotoxicity. Curr Opin Toxicol. 2021 Jun;26:49–60.
Mamane A, Baldi I, Tessier JF, Raherison C, Bouvier G. Occupational exposure to pesticides and respiratory health. Eur Respir Rev. 2015 Jun;24(136):306–19.
Aktar W, Sengupta D, Chowdhury A. Impact of pesticides use in agriculture: their benefits and hazards. Interdiscip Toxicol. 2009 Mar 1;2(1):1–12.
Ankit, Saha L, Kishor V, Bauddh K. Impacts of synthetic pesticides on soil health and non-targeted flora and fauna. Ecological and practical applications for sustainable agriculture. 2020:65-88.
Jayaraj R, Megha P, Sreedev P. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment. Interdiscip Toxicol. 2016 Dec;9(3–4):90–100.
Sponsler DB, Grozinger CM, Hitaj C, Rundlöf M, Botías C, Code A, et al. Pesticides and pollinators: A socioecological synthesis. Sci Total Environ. 2019 Apr;662:1012–27.
Majewski MS, Capel PD. Pesticides in the Atmosphere: Distribution, Trends, and Governing Factors [Internet]. 1st ed. CRC Press; 2019 [cited 2024 Oct 26]. Available from: https://www.taylorfrancis.com/books/9781439822609
Pettis JS, vanEngelsdorp D, Johnson J, Dively G. Pesticide exposure in honey bees results in increased levels of the gut pathogen Nosema. Naturwissenschaften. 2012 Feb;99(2):153–8.
Ortiz-Santaliestra ME, Alcaide V, Camarero PR, Mateo R, Mougeot F. Egg Overspray with Herbicides and Fungicides Reduces Survival of Red-Legged Partridge Chicks. Environ Sci Technol. 2020 Oct 6;54(19):12402–11.
Bedi JS, Gill JPS, Kaur P, Sharma A, Aulakh RS. Evaluation of pesticide residues in human blood samples from Punjab (India). Vet World. 2015 Jan;8(1):66–71.
Damalas CA, Eleftherohorinos IG. Pesticide Exposure, Safety Issues, and Risk Assessment Indicators. Int J Environ Res Public Health. 2011 May 6;8(5):1402–19.
Treviño MJS, Pereira-Coelho M, López AGR, Zarazúa S, Dos Santos Madureira LA, Majchrzak T, et al. How pesticides affect neonates? - Exposure, health implications and determination of metabolites. Sci Total Environ. 2023 Jan;856:158859.
Palaniswamy S, Abass K, Rysä J, Odland JØ, Grimalt JO, Rautio A, et al. Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes. Environ Int. 2021 Nov;156:106766.
Ortiz‐Martínez M, Molina González JA, Ramírez García G, De Luna Bugallo A, Justo Guerrero MA, Strupiechonski EC. Enhancing Sensitivity and Selectivity in Pesticide Detection: A Review of Cutting‐Edge Techniques. Environ Toxicol Chem. 2024 Jul;43(7):1468–84.
Caballero-Casero N, Belova L, Vervliet P, Antignac JP, Castaño A, Debrauwer L, et al. Towards harmonised criteria in quality assurance and quality control of suspect and non-target LC-HRMS analytical workflows for screening of emerging contaminants in human biomonitoring. TrAC Trends Anal Chem. 2021 Mar;136:116201.
Van Der Hoff GR, Van Zoonen P. Trace analysis of pesticides by gas chromatography. J Chromatogr A. 1999 May;843(1–2):301–22.
Mahara BM, Borossay J, Torkos K. Liquid–Liquid Extraction for Sample Preparation prior to Gas Chromatography and Gas Chromatography–Mass Spectrometry Determination of Herbicide and Pesticide Compounds. Microchem J. 1998 Jan;58(1):31–8.
Nováková L, Svoboda P, Pavlík J. Ultra-high performance liquid chromatography. In: Liquid Chromatography [Internet]. Elsevier; 2017 [cited 2024 Oct 26]. p. 719–69. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780128053935000294
Bandini E, Schuster SA, Rahmani T, Lynen F. Maximizing sensitivity and selectivity in LC × LC-HRMS for pesticide analysis via exploitation of per-aqueous liquid chromatography. J Chromatogr A. 2024 Oct;465403.
Wang J, Suzuki H, Satake T. Coulometric microdevice for organophosphate pesticide detection. Sens Actuators B Chem. 2014 Dec;204:297–301.
Thakkar JB, Gupta S, Prabha CR. Acetylcholine esterase enzyme doped multiwalled carbon nanotubes for the detection of organophosphorus pesticide using cyclic voltammetry. Int J Biol Macromol. 2019 Sep;137:895–903.
Dashti A, Navidpour AH, Amirkhani F, Zhou JL, Altaee A. Application of machine learning models to improve the prediction of pesticide photodegradation in water by ZnO-based photocatalysts. Chemosphere. 2024 Aug;362:142792.
Brás I, Santos L, Alves A. Monitoring organochlorine pesticides from landfill leachates by gas chromatography–electron-capture detection after solid-phase microextraction. J Chromatogr A. 2000 Sep;891(2):305–11.
Abdu Hussen A. High-Performance Liquid Chromatography (HPLC): A review. Ann Adv Chem. 2022 Jun 20;6(1):010–20.
Hogendoorn EA. High‐Performance Liquid Chromatography Methods in Pesticide Residue Analysis. In: Meyers RA, editor. Encyclopedia of Analytical Chemistry [Internet]. 1st ed. Wiley; 2000 [cited 2024 Oct 26]. Available from: https://onlinelibrary.wiley.com/doi/10.1002/9780470027318.a1712
Hogendoorn E, Van Zoonen P. Recent and future developments of liquid chromatography in pesticide trace analysis. J Chromatogr A. 2000 Sep;892(1–2):435–53.
Agüera A, Piedra L, Hernando MD, Fernández-Alba AR, Contreras M. Splitless large-volume GC-MS injection for the analysis of organophosphorus and organochlorine pesticides in vegetables using a miniaturised ethyl acetate extraction. The Analyst. 2000;125(8):1397–402.
De Pinho GP, Neves AA, De Queiroz MELR, Silvério FO. Optimization of the liquid–liquid extraction method and low temperature purification (LLE–LTP) for pesticide residue analysis in honey samples by gas chromatography. Food Control. 2010 Oct;21(10):1307–11.
Farajzadeh MA, Khoshmaram L, Nabil AAA. Determination of pyrethroid pesticides residues in vegetable oils using liquid–liquid extraction and dispersive liquid–liquid microextraction followed by gas chromatography–flame ionization detection. J Food Compos Anal. 2014 Jun;34(2):128–35.
Kujawski MW, Bargańska Ż, Marciniak K, Miedzianowska E, Kujawski JK, Ślebioda M, et al. Determining pesticide contamination in honey by LC-ESI-MS/MS – Comparison of pesticide recoveries of two liquid–liquid extraction based approaches. LWT - Food Sci Technol. 2014 May;56(2):517–23.
Alzaga R, Durand G, Barceló D, Bayona JM. Comparison of supercritical fluid extraction and liquid-liquid extraction for isolation of selected pesticides stored in freeze-dried water samples. Chromatographia. 1994 Apr;38(7–8):502–8.
Ramesh A, Ravi PE. Electron ionization gas chromatography–mass spectrometric determination of residues of thirteen pyrethroid insecticides in whole blood. J Chromatogr B. 2004 Apr;802(2):371–6.
Corrion ML, Ostrea EM, Bielawski DM, Posecion NC, Seagraves JJ. Detection of prenatal exposure to several classes of environmental toxicants and their metabolites by gas chromatography–mass spectrometry in maternal and umbilical cord blood. J Chromatogr B. 2005 Aug;822(1–2):221–9.
Čajka T, Hajšlová J. Gas chromatography–high-resolution time-of-flight mass spectrometry in pesticide residue analysis: advantages and limitations. J Chromatogr A. 2004 Nov;1058(1–2):251–61.
Kirchner M, Húšková R, Matisová E, Mocák J. Fast gas chromatography for pesticide residues analysis using analyte protectants. J Chromatogr A. 2008 Apr;1186(1–2):271–80.
Kirchner M, Matisová E, Otrekal R, Hercegová A, Zeeuw JD. Search on ruggedness of fast gas chromatography–mass spectrometry in pesticide residues analysis. J Chromatogr A. 2005 Aug;1084(1–2):63–70.
Guo Y, Liu X, Sun X, Cao Y, Wang X. A PDMS Microfluidic Impedance Immunosensor for Sensitive Detection Of Pesticide Residues in Vegetable Real Samples. Int J Electrochem Sci. 2015 May;10(5):4155–64.
Sandahl M, Mathiasson L, Jönsson JÅ. Determination of thiophanate-methyl and its metabolites at trace level in spiked natural water using the supported liquid membrane extraction and the microporous membrane liquid–liquid extraction techniques combined on-line with high-performance liquid chromatography. J Chromatogr A. 2000 Sep;893(1):123–31.
Wu CC, Chu C, Wang YS, Lur HS. Multiresidue method for high-performance liquid chromatography determination of carbamate pesticides residues in tea samples. J Environ Sci Health Part B. 2008 Dec 24;44(1):58–68.
Topuz S, Özhan G, Alpertunga B. Simultaneous determination of various pesticides in fruit juices by HPLC-DAD. Food Control. 2005 Jan;16(1):87–92.
Straube EA, Dekant W, Völkel W. Comparison of electrospray ionization, atmospheric pressure chemical ionization, and atmospheric pressure photoionization for the analysis of dinitropyrene and aminonitropyrene LC-MS/MS. J Am Soc Mass Spectrom. 2004 Dec 1;15(12):1853–62.
Olsson AO, Baker SE, Nguyen JV, Romanoff LC, Udunka SO, Walker RD, et al. A Liquid Chromatography−Tandem Mass Spectrometry Multiresidue Method for Quantification of Specific Metabolites of Organophosphorus Pesticides, Synthetic Pyrethroids, Selected Herbicides, and DEET in Human Urine. Anal Chem. 2004 May 1;76(9):2453–61.
Sottani C, Bettinelli M, Fiorentino ML, Minoia C. Analytical method for the quantitative determination of urinary ethylenethiourea by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2003 Oct 30;17(20):2253–9.
Sancho JV, Pozo OJ, López FJ, Hernández F. Different quantitation approaches for xenobiotics in human urine samples by liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 2002 Apr 15;16(7):639–45.
Raina-Fulton R, Dunn N, Xie Z. Pesticides and Their Degradation Products Including Metabolites: Chromatography-Mass Spectrometry Methods. In: Aliofkhazraei M, editor. Mass Spectrometry [Internet]. InTech; 2017 [cited 2024 Oct 26]. Available from: http://www.intechopen.com/books/mass-spectrometry/pesticides-and-their-degradation-products-including-metabolites-chromatography-mass-spectrometry-met
Merhi A, Taleb R, Elaridi J, Hassan HF. Analytical methods used to determine pesticide residues in tea: A systematic review. Appl Food Res. 2022 Jun;2(1):100131.
Rahman. Application of computational methods in isolation of plant secondary metabolites. Comput Phytochem. 2018;107–39.
Leandro CC, Hancock P, Fussell RJ, Keely BJ. Comparison of ultra-performance liquid chromatography and high-performance liquid chromatography for the determination of priority pesticides in baby foods by tandem quadrupole mass spectrometry. J Chromatogr A. 2006 Jan;1103(1):94–101.
Basharat R, Kotra V, Loong LY, Mathews A, Kanakal MM, Dev CBP, et al. A Mini-review on Ultra Performance Liquid Chromatography. Orient J Chem. 2021 Aug 30;37(4):847–57.
Rejczak T, Tuzimski T. Recent Trends in Sample Preparation and Liquid Chromatography/Mass Spectrometry for Pesticide Residue Analysis in Food and Related Matrixes. J AOAC Int. 2015 Sep 1;98(5):1143–62.
López-Ruiz R, Romero-González R, Garrido Frenich A. Ultrahigh-pressure liquid chromatography-mass spectrometry: An overview of the last decade. TrAC Trends Anal Chem. 2019 Sep;118:170–81.
Petrovic M, Gros M, Barcelo D. Multi-residue analysis of pharmaceuticals in wastewater by ultra-performance liquid chromatography–quadrupole–time-of-flight mass spectrometry. J Chromatogr A. 2006 Aug;1124(1–2):68–81.
Pozo OJ, Barreda M, Sancho JV, Hernández F, Ll. Lliberia J, Cortés MA, et al. Multiresidue pesticide analysis of fruits by ultra-performance liquid chromatography tandem mass spectrometry. Anal Bioanal Chem. 2007 Nov;389(6):1765–71.
Walorczyk S, Drożdżyński D, Kierzek R. Determination of pesticide residues in samples of green minor crops by gas chromatography and ultra performance liquid chromatography coupled to tandem quadrupole mass spectrometry. Talanta. 2015 Jan;132:197–204.
Gao H, Yan C, Wu W, Li J. Application of Microfluidic Chip Technology in Food Safety Sensing. Sensors. 2020 Mar 24;20(6):1792.
Hossain SMZ, Luckham RE, McFadden MJ, Brennan JD. Reagentless Bidirectional Lateral Flow Bioactive Paper Sensors for Detection of Pesticides in Beverage and Food Samples. Anal Chem. 2009 Nov 1;81(21):9055–64.
Lu D, Liu C, Deng J, Zhou X, Shi G, Zhou T. Rational design of an ionic liquid dispersive liquid–liquid micro-extraction method for the detection of organophosphorus pesticides. The Analyst. 2019;144(6):2166–72.
Wang YL, You LQ, Mei YW, Liu JP, He LJ. Benzyl Functionalized Ionic Liquid as New Extraction Solvent of Dispersive Liquid-liquid Microextraction for Enrichment of Organophosphorus Pesticides and Aromatic Compounds. Chin J Anal Chem. 2016 Jun;44(6):942–9.
Bilal S, Mudassir Hassan M, Fayyaz Ur Rehman M, Nasir M, Jamil Sami A, Hayat A. An insect acetylcholinesterase biosensor utilizing WO3/g-C3N4 nanocomposite modified pencil graphite electrode for phosmet detection in stored grains. Food Chem. 2021 Jun;346:128894.
Zhao G, Zhou B, Wang X, Shen J, Zhao B. Detection of organophosphorus pesticides by nanogold/mercaptomethamidophos multi-residue electrochemical biosensor. Food Chem. 2021 Aug;354:129511.
Wang H, Zhao G, Chen D, Wang Z, Liu G. A Sensitive Acetylcholinesterase Biosensor Based on Screen Printed Electrode Modified with FeO Nanoparticle and Graphene for Chlorpyrifos Determination. Int J Electrochem Sci. 2016 Dec;11(12):10906–18.
Li F, Fan D, Wang H, Yang H, Li W, Tang Y, et al. In silico prediction of pesticide aquatic toxicity with chemical category approaches. Toxicol Res. 2017;6(6):831–42.
Fukushima AR, Peña-Muñoz JW, Leoni LAB, Nicoletti MA, Ferreira GM, Delorenzi JCMOB, et al. Development, Optimization, and Validation of Forensic Analytical Method for Quantification of Anticholinesterase Pesticides in Biological Matrices from Suspected Cases of Animal Poisoning. Toxics. 2022 May 23;10(5):269.
Cox J, Mathison K, Ott C, DelTondo J, Kraner JC, DeCaprio AP, et al. Quantitation and Validation of 34 Fentanyl Analogs from Liver Tissue Using a QuEChERS Extraction and LC–MS-MS Analysis. J Anal Toxicol. 2022 Mar 21;46(3):232–45.
Mouskeftara T, Virgiliou C, Iakovakis A, Raikos N, Gika HG. Liquid chromatography tandem mass spectrometry for the determination of nine insecticides and fungicides in human postmortem blood and urine. J Chromatogr B. 2021 Aug;1179:122824.
Simonelli A, Carfora A, Basilicata P, Liguori B, Mascolo P, Policino F, et al. Suicide by Pesticide (Phorate) Ingestion: Case Report and Review of Literature. Toxics. 2022 Apr 21;10(5):205.
Tozzi Wurzler G, Da Silva Antonio A, De Andrade Bhering C, Machado Pereira Ajuz A, Rissi Carvalhosa D, Celso Jardim A, et al. Fast high-resolution mass spectrometry in the triage investigation of poisonings by pesticides in unusual samples - a case study. Forensic Chem. 2024 Mar;37:100555.
Çelik S, Akbaba M, Nazlıcan E, Gören İE, Yavuz Güzel E, Daglioglu N. Association between occupational and environmental pesticide exposure in Cukurova region by hair and blood biomonitoring. Environ Sci Pollut Res. 2021 Nov;28(44):63191–201.
Su H, Lin HH, Su LJ, Lin CC, Jiang ZH, Chen SJ, et al. Direct immersion solid-phase microextraction combined with ambient ionization tandem mass spectrometry to rapidly distinguish pesticides in serum for emergency diagnostics. J Food Drug Anal. 2022 Mar 16;30(1):26–37.
Tu H, Wei X, Pan Y, Tang Z, Yin R, Qin J, et al. Neonicotinoid insecticides and their metabolites: Specimens tested, analytical methods and exposure characteristics in humans. J Hazard Mater. 2023 Sep;457:131728.
Sinha SN, Kumar KR, Ungarala R, Kumar D, Deshpande A, Vasudev K, et al. Toxicokinetic analysis of commonly used pesticides using data on acute poisoning cases from Hyderabad, South India. Chemosphere. 2021 Apr;268:129488.
Buchholz BA, Ahn KC, Huang H, Gee SJ, Stewart BJ, Ognibene TJ, et al. Pharmacokinetics, Metabolite Measurement, and Biomarker Identification of Dermal Exposure to Permethrin Using Accelerator Mass Spectrometry. Toxicol Sci. 2021 Aug 30;183(1):49–59.
Perovani IS, Mariano Bucci JL, Carrão DB, Santos Barbetta MF, Moreira Da Silva R, Lopes NP, et al. Enantioselective inhibition of human CYP2C19 by the chiral pesticide ethofumesate: Prediction of pesticide-drug interactions in humans. Chem Biol Interact. 2021 Aug;345:109552.
Birolli WG, Lanças FM, Dos Santos Neto ÁJ, Silveira HCS. Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications. Front Public Health. 2024 Jun 12;12:1336014.
Fama F, Feltracco M, Moro G, Barbaro E, Bassanello M, Gambaro A, et al. Pesticides monitoring in biological fluids: Mapping the gaps in analytical strategies. Talanta. 2023 Feb;253:123969.
Facure MHM, Mercante LA, Mattoso LHC, Correa DS. Detection of trace levels of organophosphate pesticides using an electronic tongue based on graphene hybrid nanocomposites. Talanta. 2017 May;167:59–66.
Oliveira IG, Grecco CF, de Souza ID, Queiroz ME. Current chromatographic methods to determine cannabinoids in biological samples: a review of the state-of-the art on sample preparation techniques. Green Analytical Chemistry. 2024 Oct 6:100161.
Mitra S, Saran RK, Srivastava S, Rensing C. Pesticides in the environment: Degradation routes, pesticide transformation products and ecotoxicological considerations. Sci Total Environ. 2024 Jul;935:173026.
Ambrus Á, Doan VVN, Szenczi-Cseh J, Szemánné-Dobrik H, Vásárhelyi A. Quality Control of Pesticide Residue Measurements and Evaluation of Their Results. Molecules. 2023 Jan 18;28(3):954.
Mousavi SR, Hakemi A. Artificial Intelligence (AI) and Insecticides in Pest Control. 2024; vol. 16, S. Kumar, Ed., IntechOpen, 2024.
D. B. Olawade, O. Z. Wada, A. O. Ige, B. I. Egbewole, A. Olojo, and B. I. Oladapo. Artificial intelligence in environmental monitoring: Advancements, challenges, and future directions. Hyg. Environ. Health Adv., 2024 Dec. 12, p. 100114.
Yousef HA, Fahmy HM, Arafa FN, Abd Allah MY, Tawfik YM, El Halwany KK, El-Ashmanty BA, Al-Anany FS, Mohamed MA, Bassily ME. Nanotechnology in pest management: advantages, applications, and challenges. International Journal of Tropical Insect Science. 2023 Oct;43(5):1387-99.
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