Estimation of serum uric acid level in association with pattern and severity of psoriatic arthritis
Keywords:
PsA disease Activity, Hyperuricemia, Inflammation, Uric AcidAbstract
Background: Psoriatic arthritis (PsA), a chronic inflammatory disorder, is increasingly associated with hyperuricemia. This study aimed to estimate serum uric acid (SUA) levels in PsA patients compared to healthy controls and evaluate their association with disease activity and subtypes.
Methods: A case-control study was employed, recruiting 40 PsA patients meeting Classification Criteria for Psoriatic Arthritis (CASPAR) criteria and 40 age- and gender-matched clinically healthy controls. Disease activity was assessed via the Disease Activity Index for Psoriatic Arthritis (DAPSA), and fasting SUA levels were measured enzymatically
Results: The SUA levels did not show a statistically significant difference across the clinical patterns of PsA. The most common clinical pattern of PsA observed was Polyarthritis Rheumatoid like, found in 14 (35.0%) patients. The relationship between uric acid levels and the severity of arthritis was also examined. Among 3 (7.5%) patients in remission, the mean ± SD of uric acid was 4.60 ± 0.000, with a 95% CI of (4.60 - 4.60). For 29 (72.5%) patients with low disease activity, the mean ± SD was 4.81 ± 1.139, with a 95% CI of (4.3688 - 5.2353). In 8 (20%) patients with moderate disease activity, the mean ± SD of uric acid was 7.83 ± 1.84, with a 95% CI of (6.2951 - 9.3674). Therefore, the severity of the disease significantly affected SUA levels (P < 0.001).
Conclusions: Research findings demonstrated that levels of SUA failed to show any connection to PsA clinical patterns. Higher disease activity of PsA led to increased SUA levels among PsA patients. Patients who were in remission stages demonstrated the lowest concentration of serum uric acid level, yet patients marked by moderate disease activity levels showed the highest serum uric acid levels..
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References
Husni E, Michael M: Oxford textbook of Psoriatic arthritis: Epidemiology of PsA. Oxford university. 2018.
Tripolino C, Ciaffi J, Ruscitti P, Giacomelli R, Meliconi R, Ursini F. Hyperuricemia in psoriatic arthritis: epidemiology, pathophysiology, and clinical implications. Front.Med. 2021 Sep 22;8:737573.
Liu Z, Ma X, Chang T, Yao C, Song M, Biyue S, Zhang F, Liu J, Jiang Q. Associations between psoriasis, psoriatic arthritis and gout or hyperuricemia: a systematic review and meta-analysis. Am J Med Sci. 2025 Feb 15.
Widawski L, Fabacher T, Spielmann L, Gottenberg JE, Sibilia J, Duret PM, Messer L, Felten R. Psoriatic arthritis with hyperuricemia: more peripheral, destructive, and challenging to treat. Clin Rheumatol. 2022 May;41(5):1421–9.
Lai TL, Yim CW, Wong PY, Leung MC, Ng WL. Hyperuricemia in Asian psoriatic arthritis patients. Int J Rheum Dis. 2018 Apr;21(4):843–9.
Hu M, Wang Y, Xu W, Bai J, Tang X. The impact of serum uric acid on psoriasis: NHANES 2005–2014 and Mendelian randomization. Front Genet. 2024 May 9;15:1334781.
Perković D, Petrić M, Maleš M, Erceg Maleš I, Radić M. Biological disease-modifying antirheumatic drugs decrease uric acid levels in the sera of patients with psoriatic arthritis. Curr Issues Mol Biol. 2025 Feb 22;47(3):142
West SG, Kolfenbach J. Rheumatology secrets. 4th ed. Philadelphia: Elsevier; 2020.
Walsh JA, Adejoro O, Chastek B, Palmer JB, Hur P. Treatment patterns among patients with psoriatic arthritis treated with a biologic in the United States: descriptive analyses from an administrative claims database. J Manag Care Spec Pharm. 2018 Jul;24(7):623–31.
De Marco G, Zabotti A, Baraliakos X, Iagnocco A, Aletaha D, Gisondi P, Emmel J, Smolen JS, McGonagle DG, Gossec L. Characterisation of prodromal and very early psoriatic arthritis: a systematic literature review informing a EULAR taskforce. RMD Open. 2023 Jun 1;9(2):e003143.
Kim HA, Lee E, Park SY, Lee SS, Shin K. Clinical characteristics of patients with psoriatic spondylitis versus those with ankylosing spondylitis: features at baseline before biologic therapy. J Korean Med Sci. 2022 Aug 22;37(33).
Sultan N, Chaudhry AA, Butt G, Rehman S, Aman S, Shoaib T. Clinical patterns of psoriatic arthritis & association with age & gender among patients presenting to a tertiary care hospital. J Pak Assoc Dermatol. 2020 Aug 7;30(1):151–5.
Ambike J, Gosavi A, Pradhan S, Belgaumkar V. Association of serum calcium level and serum uric acid level in psoriasis and its correlation with severity of psoriasis. Dermatol Rev (Przegl Dermatol). 2024;111(1):20–5.
Yehia HY, Ghanayem NM, El Farargy SM. Association between serum uric acid concentration and clinical features of psoriasis. Menoufia Med J. 2021;34(4):1255–8.
Ragab HM, Elsergany MA, Mehanna RY, Ibrahim AM. Endothelial dysfunction in psoriatic arthritis patients: relation to serum uric acid and disease activity. Egypt J Intern Med. 2025 Apr 24;37(1):61..
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