Formulation, Development & Characterization of Gels of Extracts of Butea monosperma & Acacia arabica Linn. & Evaluation of Wound healing Activity
Keywords:
Formulation, Development, Characterization of Gels, Extracts, Butea monosperma & Acacia arabica Linn, Wound healing ActivityAbstract
The extracts were tested for acute oral and dermal toxicity studies on the basis of OECD guidelines. Normal healthy albino rats were chooses and grouped for the wound healing study. The excision, incision and dead space wounds were implicated on back side of albino rats. In excision wound model extracts were applied topically for 14 days. At the end of study Wound area, % wound closure and day of epitheliazation were calculated.
In incision wound model all extracts were administered orally at a dose of 200 mg/kg body weight for 14 days. At the end of study tensile strength (Skin breaking strength) was measured with the help of tensiometer.
In Dead Space wound model all extracts were administered orally at a dose of 200 mg/kg body weight for 14 days. At the end of treatment the wet and dry weight of granulation tissue, hydroxyproline content with % collagen and % elastin level were measured. Some antioxidant parameters like SOD, GSH, and Catalase and lipid per oxidation level also estimated in blood of rats of dead space wound model. Among all extracts ethanolic extract of bark of Acacia arabica and Butea monosperma were found to be most effective in management of delayed wound healing.
The acute (Oral and Dermal) toxicity studies, excision, incision and dead space wound model were implicated for wound healing activity of ethanolic extract of Acacia arabica and Butea monosperma with all biophysical and biochemical parameter estimation same described above for examination of extract.
On the basis of above investigations, it is concluded that the ethanolic extract of bark of Acacia arabica and Butea monosperma have effective role in treatment of delayed wound healing in normal albino rats
Downloads
References
Chittodiya, Prateek. et al., “Topical Gel - A Review.” International Journal of Pharmaceutical & Biological Archives, (2013): 606-613.
Latheeshjlal, L. et al., “Transdermal Drug Delivery Systems: An Overview, International.” Journal of PharmTech Research (2011): 2140-2148.
Patel, Harshil M. et al., “Formulation Development & Evaluation of Econazole Nitrate Topical Emulgel”, International Journal of Advances in Pharmaceutics (2018): 48-56.
Patil P.B. et al., “A Review on Topical Gels as Drug Delivery System.” Journal of Drug Delivery & Therapeutics, (2019): 989-994.
Pereira, Rubia L. et al., “Hydrogel containing adapalene and dapsone loaded lipid-core nanocapsules for cutaneous application: development, characterization, in vitro irritation and permeation studies”, Drug Development and Industrial Pharmacy (2016): 1-31.
Ramya Devi D. et al., “In-Situ Gelling System – Potential Tool for Improving Therapeutic Effects Of Drugs”, International Journal of Pharmacy and Pharmaceutical Sciences (2013): 27-30.
Sahoo, Chinmaya K. et al., “Formulation and evaluation of bifonazole organogel for the application of topical drug delivery system”, Der Pharmacia Sinica (2013): 67-74.
Saroha Kamal et al., “Transdermal Gels - An Alternative Vehicle For Drug Delivery”, International Journal of Pharmaceutical, Chemical and Biological Sciences (2013) 495-503.
Thiboutot, D. M., “Endocrinological Evaluation and Hormonal Therapy for Women with Difficult Acne”, Journal of European Academy of Dermatology and Venereology (2001): 57-61.
Thielitz, A. et al., “Lipid Analysis of Follicular Casts from Cyanoacrylate Strips as a New Method for Studying Therapeutic Effects of Antiacne Agents”, British Journal of Dermatology (2001): 19-27.
Tiwari, Ruchi et al., “Development, Characterization and Transdermal Delivery of Dapsone and an Antibiotic Entrapped in Ethanolic Liposomal Gel for the Treatment of Lapromatous Leprosy”, The Open Nanomedicine Journal (2018): 1-15.
Tran, P. et al., “Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs”, Pharmaceutics (2019): 1-26.
Verma Ashni et al., “Topical Gels as Drug Delivery Systems: A Review”, International Journal of Pharmaceutical Sciences Review and Research (2013): 374-382.
Wester, Ronald, C. et al., “Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy”, Journal of the American Academy of Dermatology (1991): 720-726.
Wysowski, Diane, K. et al., “Use of isotretinoin (Accutane) in the United States: Rapid increase from 1992 through 2000”, Journal of the American Academy of Dermatology (2002): 505-509.
Yeo, Pei L. et al., “Niosomes: a review of their structure, properties, methods of preparation, and medical applications”, Asian Biomed (Res Rev News) (2017): 301–314.
Yilmaz, Gulsen et al., “Preparation and In Vitro Characterization of Etofenamate Emulgels Using Quality by Design”, Journal of Research in Pharmacy (2019): 1033-1039.
Zu, Yuangang et al., “Activities of ten essential oils towards propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells”, Molecules (2010): 3200-3210.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
