Psychological Determinants In The Etiopathogenesis Of Pandu Roga: An Ayurvedic Review W.S.R. To Iron Deficiency Anemia

Abstract

Pandu Roga, as outlined in Ayurvedic literature, is a disorder presenting with pallor and systemic weakness, closely aligning with clinical features of iron deficiency anemia. Classical Ayurvedic sources attribute its pathogenesis to both physical and psychological factors. Notably, Acharya Charaka highlights Chinta (worry), Bhaya (fear), and Shoka (grief) as key psychological contributors. These factors are believed to impair the functioning of Rasavaha and Raktavaha Srotas, thereby disrupting the formation of Rasa and Rakta Dhatus. Contemporary biomedical research corroborates these insights by demonstrating that psychological stress can interfere with iron regulation, erythropoiesis, and inflammatory processes via hypothalamic-pituitary-adrenal (HPA) axis dysregulation. This review synthesizes classical Ayurvedic concepts with current scientific findings to explore the etiological role of mental stressors in Pandu Roga. Literature was gathered through systematic keyword searches including “iron deficiency,” “psychological stress,” “anemia,” and “HPA axis,” followed by evaluation of relevant studies. Results indicate that prolonged psychological stress negatively impacts iron homeostasis and hematopoiesis, potentially precipitating anemia. These findings support the inclusion of psychological assessment and management in the holistic treatment of Pandu Roga.