Design and Fabrication of a New Model to Evaluate Analgesic, Antipyretic and Anti-inflammatory Action of a Drug
Keywords:
Design, fabrication, new screening methods, standardization, aspirin, multiple actions, new model designAbstract
The purpose of present study is based on the fact that many drugs have more than one action and evaluation of one action of a drug requires one whole screening model whereas for the evaluation of other action of same drug will require one more different screening model. In this study a new model has been fabricated for the evaluation of three different actions of one drug i.e. evaluation of analgesic, anti-inflammatory and antipyretic activity. Aspirin has analgesic, antipyretic, anti-inflammatory, and antiplatelet activity. Evaluation of all the activities of aspirin, we will require four different methods and models but in our study the newly fabricated model alone will be able to evaluate three actions of a single drug
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Gurinder S., Balbir S., and Promila M., (2018), Antipyretic activity investigations on various extracts and fractions of Jwarnashak Panch Kashya, Journal of Pharmacognosy and Phytochemistry 2018; 7(3): 3017-3020
Awatif M., Saaedi A., and Zainab M., (2018), Evaluation of the antipyretic activity of the aqueous extract of Zinger (Zingiber officinale) rhizome in female rats, IOSR Journal Of Pharmacy, 8 (1) : 01-03.
Jarrod B., Michelle T., Michael B., (2014), An Analysis of the Use of Animal Models in Predicting Human Toxicology and Drug Safety, AlternLab Anim, 42 (3): 181-99.
Tinneke D., Thomas S., Maarten V., (2014), Animal models in translational medicine: Validation and prediction, European Society for Translational Medicine, 2 (1): 5–11
Ray G., and Andre M., (2010), Systematic Reviews of Animal Models: Methodology versus Epistemology, International Journal of Medical Sciences, 10 (3): 206-221.
Crews E L, Fuge K W, Oscai L B, Holloszy J O and Shank R E.Weight, food intake and body composition: effects of exerciseand of protein deficiency. Amer J Physiol, 216:359-363, 1969.
Hirsch J and Han P W. Cellularity of rat adipose tissue: effectsof growth, starvation and obesity. Journal of Lipid Research,10:77-82, 1969.
Johnson P R, Zucker L M, Cruce J A F and Hirsch J. Cellularity ofadipose depots in the genetically obese zucker rat. Journal ofLipid Research, 12:706-714, 1971.
Kregel K C. Design of animal exercise protocol. 1st ed,American Physiological Society, Bethesda MD, 2006.
Oscai L B, Spirakis C N, Wolff C A, Beck R J. Effects of exerciseand of food restriction on adipose tissue cellularity. Journal oflipid research 13:588-592, 1972.
Scalfani A, Springer D. Dietary obesity in adult rats:similarities to hypothalamic and human obesity syndromes.Physiol Behav, 17:461–471, 1976.
Vogel H G. Drug Discovery and Evaluation: Pharmacologicalassays. 2nd ed, Springer-Verlag, Berlin Heidelberg New York, 2002.
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