Prevalence and Correlates of Chemotherapy-Induced Cognitive Impairment in Cancer Patients at Mahavir Cancer Sansthan, Patna: A Cross-Sectional Study
DOI:
https://doi.org/10.63682/jns.v14i29S.6859Keywords:
Cognitive Impairment, Cancer, Chemotherapy, MoCAAbstract
Cancer-related cognitive impairment (CRCI) significantly impacts the quality of life of cancer survivors, yet awareness of its effects remains limited. This cross-sectional study at Mahavir Cancer Sansthan, Patna, assessed the proportion of cognitive impairment among 140 chemotherapy-treated cancer patients using the Montreal Cognitive Assessment (MoCA). Findings revealed that 78.5% (110 patients) exhibited cognitive deficits, particularly in attention and memory, while only 30 showed no impairment. The study highlights the high prevalence of CRCI, emphasizing the need for early detection and supportive care in oncology practice. Although no significant correlations were found between cognitive impairment and variables like age, gender, or cancer stage, the results align with existing evidence of chemotherapy-induced cognitive dysfunction. The study underscores the necessity for further research to identify predictors of CRCI and develop targeted interventions. Oncology nurses play a crucial role in educating patients and managing cognitive side effects, ensuring better survivorship care. This study serves as a foundational step in addressing CRCI in Bihar’s cancer population, advocating for integrated cognitive assessments in treatment protocols to improve patient outcomes..
Downloads
Metrics
References
Ahles, T. A., & Root, J. C. (2018). Cognitive effects of cancer and cancer treatments. Annual Review of Clinical Psychology, 14, 425–451. https://doi.org/10.1146/annurev-clinpsy-050817-084903
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., & Snyder, P. J. (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia, 7(3), 270–279. https://doi.org/10.1016/j.jalz.2011.03.008
Anguiano, L., Mayer, D. K., Piven, M. L., & Rosenstein, D. (2012). A literature review of suicide in cancer patients. Cancer Nursing, 35(4), E14–E26. https://doi.org/10.1097/NCC.0b013e31822fc76c
Hamza Shuja, K., Aqeel, M., Jaffar, A., & Ahmed, A. (2020). COVID-19 pandemic and impending global mental health implications. Psychiatria Danubina, 32(1), 32–35. https://doi.org/10.24869/psyd.2020.32
Hossain, M. M., Tasnim, S., Sultana, A., Faizah, F., Mazumder, H., Zou, L., McKyer, E. L., Ahmed, H. U., & Ma, P. (2020). Epidemiology of mental health problems in COVID-19: A review. F1000Research, 9, 636. https://doi.org/10.12688/f1000research.24457.1
Janelsins, M. C., Heckler, C. E., Peppone, L. J., Kamen, C., Mustian, K. M., Mohile, S. G., Magnuson, A., Kleckner, I. R., Guido, J. J., Young, K. L., & Conlin, A. K. (2017). Cognitive complaints in survivors of breast cancer after chemotherapy compared with age-matched controls: An analysis from a nationwide, multicenter, prospective longitudinal study. Journal of Clinical Oncology, 35(5), 506–514. https://doi.org/10.1200/JCO.2016.68.5826
Janelsins, M. C., Kesler, S. R., Ahles, T. A., & Morrow, G. R. (2014). Prevalence, mechanisms, and management of cancer-related cognitive impairment. International Review of Psychiatry, 26(1), 102–113. https://doi.org/10.3109/09540261.2013.864260
Langa, K. M., & Levine, D. A. (2014). The diagnosis and management of mild cognitive impairment: A clinical review. JAMA, 312(23), 2551–2561. https://doi.org/10.1001/jama.2014.13806
Saha, P., Kumar, A., Bhanja, J., Shaik, R., Kawale, A. L., & Kumar, R. (2022). A review of immune blockade safety and antitumor activity of dostarlimab therapy in endometrial cancer. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 201-209.
Lucas, A. (n.d.). Cognitive impairment in patients with breast cancer. [Unpublished manuscript or presentation].
Martin, E. (2019). Defining cancer: Causes and treatments. Micro Reviews in Cell and Molecular Biology, 5(2). [No DOI available]
Ness, K. K., Krull, K. R., Jones, K. E., Mulrooney, D. A., Armstrong, G. T., Green, D. M., Chemaitilly, W., Smith, W. A., Wilson, C. L., Sklar, C. A., & Shelton, K. (2013). Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: A report from the St Jude Lifetime cohort study. Journal of Clinical Oncology, 31(36), 4496–4503. https://doi.org/10.1200/JCO.2013.52.2268
Peairs, K. S. (2017). Care of cancer survivors, An Issue of Medical Clinics of North America. Elsevier Health Sciences.
Kumar, R., & Saha, P. (2022). A review on artificial intelligence and machine learning to improve cancer management and drug discovery. International Journal for Research in Applied Sciences and Biotechnology, 9(3), 149-156.
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., & Writing Group Members. (2012). Heart disease and stroke statistics—2012 update: A report from the American Heart Association. Circulation, 125(1), e2–e20. https://doi.org/10.1161/CIR.0b013e31823ac046
Rowland, J. H., & Bellizzi, K. M. (2014). Cancer survivorship issues: Life after treatment and implications for an aging population. Journal of Clinical Oncology, 32(24), 2662–2668. https://doi.org/10.1200/JCO.2014.55.8361
Shahbaz, M., Naeem, H., Momal, U., Imran, M., Alsagaby, S. A., Al Abdulmonem, W., ... & Al Jbawi, E. (2023). Anticancer and apoptosis inducing potential of quercetin against a wide range of human malignancies. International Journal of Food Properties, 26(1), 2590-2626.
Shi, L., Lu, Z. A., Que, J. Y., Huang, X. L., Liu, L., Ran, M. S., Gong, Y. M., Yuan, K., Yan, W., Sun, Y. K., & Shi, J. (2020). Prevalence of and risk factors associated with mental health symptoms among the general population in China during the coronavirus disease 2019 pandemic. JAMA Network Open, 3(7), e2014053. https://doi.org/10.1001/jamanetworkopen.2020.14053
Skeel, R. T., & Khleif, S. N. (Eds.). (2011). Handbook of cancer chemotherapy. Lippincott Williams & Wilkins.
van Vulpen, M., Kal, H. B., Taphoorn, M. J., & El Sharouni, S. Y. (2002). Changes in blood-brain barrier permeability induced by radiotherapy: Implications for timing of chemotherapy? Oncology Reports, 9(4), 683–688. https://doi.org/10.3892/or.9.4.683
Vega, J. N., Dumas, J., & Newhouse, P. A. (2017). Cognitive effects of chemotherapy and cancer-related treatments in older adults. The American Journal of Geriatric Psychiatry, 25(12), 1415–1426. https://doi.org/10.1016/j.jagp.2017.04.001
Wang, Y., Duan, Z., Ma, Z., Mao, Y., Li, X., Wilson, A., Qin, H., Ou, J., Peng, K., Zhou, F., & Li, C. (2020). Epidemiology of mental health problems among patients with cancer during COVID-19 pandemic. Translational Psychiatry, 10(1), 263. https://doi.org/10.1038/s41398-020-00950-y
Wefel, J. S., Kesler, S. R., Noll, K. R., & Schagen, S. B. (2015). Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults. CA: A Cancer Journal for Clinicians, 65(2), 123–138. https://doi.org/10.3322/caac.21258
Sultana, A., Singh, M., Kumar, A., Kumar, R., Saha, P., Kumar, R. S., & Kumar, D. (2022). To identify drug-drug interaction in cardiac patients in tertiary care hospitals. Journal for Research in Applied Sciences and Biotechnology, 1(3), 146-152.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
