Development of a Novel Quercetin Phytosome-based Topical Hydrogel for Anti-Inflammatory and Antioxidant Effects in Psoriasis
Keywords:
Antioxidant, Anti-Inflammatory, Cytokine Inhibition, Drug Release, Hydrogel, Phytosome, Psoriasis, Quercetin, Skin Permeation, Stability Study, Topical Delivery, Transdermal TherapyAbstract
Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, oxidative stress, and immune dysregulation. Quercetin, a flavonoid with potent antioxidant and anti-inflammatory properties, holds promise for psoriasis management; however, its topical application is limited by poor water solubility and low skin permeability. This study reports the development of a novel quercetin phytosome-based topical hydrogel designed to enhance quercetin bioavailability and therapeutic efficacy for psoriasis treatment. Phytosome technology facilitates the complexation of quercetin with phospholipids, improving skin penetration and stability. The optimized phytosomal formulation exhibited nanoscale particle size, favorable zeta potential, and high encapsulation efficiency, ensuring effective quercetin delivery. Incorporation into a hydrogel base provided sustained release, improved skin retention, and enhanced antioxidant activity, as confirmed by in vitro and ex vivo analyses. Furthermore, the hydrogel demonstrated significant anti-inflammatory effects by modulating key cytokines and signaling pathways implicated in psoriasis pathogenesis. Preclinical evaluations revealed the hydrogel’s efficacy in reducing epidermal hyperplasia and oxidative stress biomarkers without skin irritation. This innovative quercetin phytosome hydrogel offers a promising, safe, and effective topical strategy for managing psoriasis by targeting both inflammation and oxidative damage...
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