The Clinical and Biophysical Impacts of Voltage-Current-Frequency (VCF) Therapy Using the eMedica Device in Orthopedic Healing
DOI:
https://doi.org/10.63682/jns.v14i18S.4922Keywords:
VCF therapy, eMedica, orthopedic healing, electroceuticals, musculoskeletal regeneration, microcurrent stimulation, bone repair, bioelectric medicine.Abstract
Background:
Orthopedic disorders such as osteoarthritis, fractures, and soft tissue injuries are prevalent causes of disability and chronic pain. Traditional treatments often offer limited regenerative effects and are either invasive or prolonged. Voltage-Current-Frequency (VCF) therapy via the eMedica device introduces a targeted, electroceutical intervention that may overcome these limitations.
Objective:
To evaluate the scientific basis, therapeutic mechanisms, and observed clinical outcomes of VCF therapy in orthopedic healing, distinguishing it from conventional electromagnetic therapies such as PEMF.
Methods:
This study synthesizes findings from cellular biology, bioelectric medicine, and preliminary clinical observations. A comparative analysis was performed between VCF and existing electromagnetic therapies. Mechanistic models of VCF-induced tissue repair and inflammation modulation were also reviewed.
Results:
VCF therapy modulates cellular membrane potentials, enhances ATP synthesis, and activates tissue-specific repair pathways. Clinical observations report accelerated bone and soft tissue healing, improved joint function, and significant reductions in inflammation and pain in patients using the eMedica device.
Conclusion:
VCF therapy represents a novel, non-invasive, and biologically targeted approach to orthopedic rehabilitation. Its integration into mainstream clinical practice has the potential to revolutionize musculoskeletal healing, warranting further investigation through controlled clinical trials.
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Nguyen AT, Aris IM, Snyder BD, et al. Musculoskeletal health: an ecological study assessing disease burden and research funding. Lancet Reg Health Am. 2024;29:100661. Published 2024 Jan 8. doi:10.1016/j.lana.2023.100661
GBD 2021 Other Musculoskeletal Disorders Collaborators. Global, regional, and national burden of other musculoskeletal disorders, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(11):e670-e682. Published 2023 Oct 23. doi:10.1016/S2665-9913(23)00232-1
Scheuing WJ, Reginato AM, Deeb M, Acer Kasman S. The burden of osteoarthritis: Is it a rising problem?. Best Pract Res Clin Rheumatol. 2023;37(2):101836. doi:10.1016/j.berh.2023.101836
Tang, S., Zhang, C., Oo, W.M. et al. Osteoarthritis. Nat Rev Dis Primers 11, 10 (2025). https://doi.org/10.1038/s41572-025-00594-6
Goulian AJ, Goldstein B, Saad MA. Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications. J Clin Med. 2025;14(6):2061. Published 2025 Mar 18. doi:10.3390/jcm14062061
Plantz MA, Hsu WK. Recent Research Advances in Biologic Bone Graft Materials for Spine Surgery. Curr Rev Musculoskelet Med. 2020;13(3):318-325. doi:10.1007/s12178-020-09620-4
Polak A, Franek A, Taradaj J. High-Voltage Pulsed Current Electrical Stimulation in Wound Treatment. Adv Wound Care (New Rochelle). 2014;3(2):104-117. doi:10.1089/wound.2013.0445
Hemant Rohera, Dr. Deepak Nagpal, Dr. Gulam Saidunnisa Begum, Dr. Pratik Sheshrao Hande, & Dr. B K Manjunatha Goud. (2022). eMedica: A Potentially Groundbreaking Device for the Optimization of Cellular Frequencies in Therapeutic Interventions - An Overview of Current Research. Journal of Population Therapeutics and Clinical Pharmacology, 29(03), 1913-1917. https://doi.org/10.53555/6pxabh32
Levin, M. (2014). Endogenous bioelectric signaling networks: Exploiting voltage gradients for control of growth and form. Annual Review of Cell and Developmental Biology, 30, 33-50.
Konstantinou E, Zagoriti Z, Pyriochou A, Poulas K. Microcurrent Stimulation Triggers MAPK Signaling and TGF-β1 Release in Fibroblast and Osteoblast-Like Cell Lines. Cells. 2020;9(9):1924. Published 2020 Aug 19. doi:10.3390/cells9091924
Preetam S, Ghosh A, Mishra R, et al. Electrical stimulation: a novel therapeutic strategy to heal biological wounds. RSC Adv. 2024;14(44):32142-32173. Published 2024 Oct 11. doi:10.1039/d4ra04258a
Zheng M, Wang X, Yue O, et al. Skin-inspired gelatin-based flexible bio-electronic hydrogel for wound healing promotion and motion sensing. Biomaterials. 2021;276:121026. doi:10.1016/j.biomaterials.2021.121026
Qiao Z, Ding J, Wu C, et al. One-Pot Synthesis of Bi2 S3 /TiO2 /rGO Heterostructure with Red Light-Driven Photovoltaic Effect for Remote Electrotherapy-Assisted Wound Repair. Small. 2023;19(7):e2206231. doi:10.1002/smll.202206231
Maeng WY, Tseng WL, Li S, Koo J, Hsueh YY. Electroceuticals for peripheral nerve regeneration. Biofabrication. 2022;14(4):10.1088/1758-5090/ac8baa. Published 2022 Sep 8. doi:10.1088/1758-5090/ac8baa
Levin M, Selberg J, Rolandi M. Endogenous Bioelectrics in Development, Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine. iScience. 2019;22:519-533. doi:10.1016/j.isci.2019.11.023
Jiang Y, Soffer E. Electroceuticals for Neurogastroenterology and Motility Disorders. Curr Gastroenterol Rep. 2023;25(4):91-97. doi:10.1007/s11894-023-00866-9
Mishra S. Electroceuticals in medicine - The brave new future. Indian Heart J. 2017;69(5):685-686. doi:10.1016/j.ihj.2017.10.001
Caliogna L, Medetti M, Bina V, et al. Pulsed Electromagnetic Fields in Bone Healing: Molecular Pathways and Clinical Applications. Int J Mol Sci. 2021;22(14):7403. Published 2021 Jul 9. doi:10.3390/ijms22147403
Yuan J, Xin F, Jiang W. Underlying Signaling Pathways and Therapeutic Applications of Pulsed Electromagnetic Fields in Bone Repair. Cell Physiol Biochem. 2018;46(4):1581-1594. doi:10.1159/000489206
Wang YY, Pu XY, Shi WG, et al. Pulsed electromagnetic fields promote bone formation by activating the sAC-cAMP-PKA-CREB signaling pathway. J Cell Physiol. 2019;234(3):2807-2821. doi:10.1002/jcp.27098
Caliogna L, Bina V, Brancato AM, et al. The Role of PEMFs on Bone Healing: An In Vitro Study. Int J Mol Sci. 2022;23(22):14298. Published 2022 Nov 18. doi:10.3390/ijms232214298
Vaibhavi Vijay Kshatriya, Manoj Ramesh Kumbhare, Shraddha Vikas Jadhav, Prajakta Jaywant Thorat, Rushikesh Gajanan Bhambarge,A review on electromedicine its various properties and emerging application in various fields,Intelligent Pharmacy,Volume 2, Issue 6,2024,777-783,ISSN 2949-866X,https://doi.org/10.1016/j.ipha.2024.05.001.
Levin M, Stevenson CG. Regulation of cell behavior and tissue patterning by bioelectrical signals: challenges and opportunities for biomedical engineering. Annu Rev Biomed Eng. 2012;14:295-323. doi:10.1146/annurev-bioeng-071811-150114
Zhao M, Song B, Pu J, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006;442(7101):457-460. doi:10.1038/nature04925
Cheng N, Van Hoof H, Bockx E, et al. The effects of electric currents on ATP generation, protein synthesis, and membrane transport of rat skin. Clin Orthop Relat Res. 1982;(171):264-272.
McMakin CR, Oschman JL. Visceral and somatic disorders: tissue softening with frequency-specific microcurrent. J Altern Complement Med. 2013;19(2):170-177. doi:10.1089/acm.2012.0384
Ferrigno B, Bordett R, Duraisamy N, et al. Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration. Bioact Mater. 2020;5(3):468-485. Published 2020 Apr 7. doi:10.1016/j.bioactmat.2020.03.010
Cheng, N., Van Hoof, H., Bockx, E., et al. (1982). The effects of electric currents on ATP generation, protein synthesis, and membrane transport in rat skin. Clinical Orthopaedics and Related Research, 171, 264–272.
McMakin, C. R., Gregory, W. L., & Phillips, T. M. (2005). Cytokine changes with microcurrent treatment of fibromyalgia associated with cervical spine trauma. Journal of Bodywork and Movement Therapies, 9(3), 169–176. https://doi.org/10.1016/j.jbmt.2004.08.003
Ross, C. L., Harrison, B. S. (2017). The use of electric, magnetic, and electromagnetic field for directed cell migration and tissue regeneration: A review. Bioelectromagnetics, 38(7), 497–513. https://doi.org/10.1002/bem.22061
Eid MM, Hamed NS, Abdelbasset WK, Elkholi SM, Eladl HM, Bahey El-Deen HA. A comparative study between transcutaneous electrical nerve stimulation and pulsed electromagnetic field therapy in the management of post-herpetic neuralgia of the sciatic nerve. Medicine (Baltimore). 2022;101(44):e31433. doi:10.1097/MD.0000000000031433
Bassett CA. The development and application of pulsed electromagnetic fields (PEMFs) for ununited fractures and arthrodeses. Clin Plast Surg. 1985;12(2):259-277.
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