Role Of MicroRNAs In Regulating Bone Formation And Osteoporosis: Insights From Molecular Mechanisms
DOI:
https://doi.org/10.52783/jns.v14.3951Keywords:
MicroRNAs, Osteoporosis, Bone Mineral Density, Osteoblasts, Biomarkers, Molecular MechanismsAbstract
Osteoporosis is a multifactorial disease characterized by decreased bone density and increased fracture risk. Recent studies suggest that microRNAs (miRNAs) play critical roles in bone metabolism, influencing osteoblast and osteoclast function. This study involved a cross-sectional analysis of 100 participants, including 50 patients diagnosed with osteoporosis and 50 healthy controls. Peripheral blood samples were collected using quantitative real-time PCR to assess miRNA expression levels. Statistical analyses evaluated the correlation between specific miRNAs and bone mineral density (BMD). Our findings indicate that osteoporosis patients exhibited significantly higher levels of miR-21, miR-29a, miR-133a, miR-146a, and miR-195 than the control group. Notably, miR-29a and miR-133a showed an inverse correlation with BMD (p < 0.01), suggesting their potential role as biomarkers for osteoporosis. The elevated expression of specific miRNAs in osteoporosis highlights their involvement in regulating bone formation and resorption. Targeting these miRNAs may offer novel therapeutic strategies for managing osteoporosis. Further research is necessary to explore their functional roles and potential as biomarkers in clinical settings.
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