Comparative Efficacy of Nalbuphine Hydrochloride vs. Tramadol Hydrochloride for Post-Operative Analgesia in Orthopaedic Surgeries: A Double-Blind Randomized Control Study
DOI:
https://doi.org/10.52783/jns.v14.2486Keywords:
Nalbuphine, Tramadol, Orthopaedic Surgery, Postoperative Pain, Analgesia, Randomized Control TrialAbstract
Background: Effective postoperative analgesia is crucial for early mobilization and recovery in orthopaedic surgeries. This study compares the efficacy and safety of Nalbuphine Hydrochloride and Tramadol Hydrochloride for postoperative pain management in patients undergoing orthopaedic procedures.
Methods: A double-blind, randomized controlled trial was conducted involving 100 patients who underwent various orthopaedic surgeries. Patients were randomly assigned to receive either Nalbuphine Hydrochloride or Tramadol Hydrochloride postoperatively. The primary outcomes measured were pain intensity using the Visual Analogue Scale (VAS) at specific time intervals and adverse effects. Secondary outcomes included hemodynamic stability and the need for additional analgesic doses.
Results: Patients receiving Nalbuphine reported significantly lower VAS scores at 30 minutes (1.80 ± 0.50) and 540 minutes (2.00 ± 0.29) post-operation compared to those receiving Tramadol (2.21 ± 0.41 and 2.38 ± 0.58, respectively; p<0.01). Nalbuphine also demonstrated fewer adverse effects such as nausea and vomiting. Hemodynamic parameters were stable and comparable between the two groups.
Conclusion: Nalbuphine Hydrochloride provides superior analgesia with fewer adverse effects compared to Tramadol Hydrochloride in the postoperative management of orthopaedic patients, making it a potentially preferable option for pain control in this population.
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Ramsay, S. E., et al. (2017). Analgesic efficacy and safety of nalbuphine versus morphine for perioperative tumor ablation: a randomized, controlled, multicenter trial. Trials, 18(1), 273. https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-2034-3
Lewis, K. S., Han, N. H. (1997). Tramadol: A new centrally acting analgesic. American Journal of Health-System Pharmacy, 54(6), 643-652. https://www.ncbi.nlm.nih.gov/pubmed/9087461
Sil, S., Ghosh, T. (2021). A comparative study of the analgesic effect of tramadol versus nalbuphine in spinal anesthesia. Journal of Pain Research, 14, 1051-1060. https://www.dovepress.com/a-comparative-study-of-the-analgesic-effect-of-tramadol-versus-nalbuph-peer-reviewed-article-JPR
Edwards, J. E., et al. (2002). Single dose oral tramadol for acute postoperative pain in adults. Cochrane Database of Systematic Reviews, 2, CD003726. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003726
Gupta, A., et al. (2016). Efficacy of nalbuphine as an adjuvant to bupivacaine for caudal analgesia in children undergoing sub-umbilical surgery. Indian Journal of Anaesthesia, 60(9), 661-666. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037952/
Kumar, P., et al. (2010). Nalbuphine infusion for postoperative pain relief in children. Anesthesia & Analgesia, 110(6), 1749-1753. https://journals.lww.com/anesthesia-analgesia/Fulltext/2010/06000/Nalbuphine_Infusion_for_Postoperative_Pain_Relief.26.aspx
Barrett, A. C., et al. (2020). The comparative efficacy of nalbuphine and tramadol for postoperative analgesia. Journal of Pain & Palliative Care Pharmacotherapy, 34(1), 14-20. https://www.tandfonline.com/doi/full/10.1080/15360288.2019.1709824
Zhang, L., et al. (2019). Efficacy and safety of nalbuphine in acute pain management: a meta-analysis of randomized controlled trials. Pain Physician, 22(3), 287-302. http://www.painphysicianjournal.com/linkout?issn=1533-3159&vol=22&page=287
Martin, L. A., et al. (2018). Tramadol vs. codeine/acetaminophen after orthopedic surgery: a randomized controlled trial. The Journal of Bone and Joint Surgery. American Volume, 100(15), 1272-1278. https://journals.lww.com/jbjsjournal/Abstract/2018/08010/Tramadol_vs__Codeine_Acetaminophen_After.1.aspx
Nadler, S. B., et al. (2002). Outcomes of nalbuphine versus fentanyl for postoperative analgesia: a randomized control trial. Pain Management Nursing, 3(2), 44-50. https://www.sciencedirect.com/science/article/pii/S1524904202800765
Singh, M., et al. (2015). Postoperative nalbuphine in pediatric orthopedic surgery: a randomized, controlled study. Journal of Pediatric Orthopaedics, 35(6), 608-612. https://journals.lww.com/pedorthopaedics/Abstract/2015/08000/Postoperative_Nalbuphine_in_Pediatric_Orthopedic.17.aspx
Yoon, H. Y., et al. (2021). Comparative study of the analgesic effect of nalbuphine and tramadol in patients undergoing major surgery. Pain Research & Management, 2021, Article ID 8857294, 9 pages. https://www.hindawi.com/journals/prm/2021/8857294/
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