Assessing the role of prophylactic antibiotics in surgical site infections: a systematic review and meta-analysis

Authors

  • Chandra Pratap Dhimar
  • Aayush Vaishnaw

Keywords:

Surgical site infection, Prophylactic antibiotics, Wound infection

Abstract

The most frequent nosocomial infection in surgical patients is surgical site infection. A cephalosporin is the suggested prophylactic antibiotic for the majority of patients having clean-contaminated operations (such as cardiothoracic, gastrointestinal, orthopedic, vascular, and gynecologic). The public is informed about hospitals' adherence to infection control protocols. Primary care doctors should be aware of the Surgical Care Improvement Project's recommendations since they assist with patients' pre- and postoperative care. This meta-analysis and systematic review aim to evaluate the effectiveness of prophylactic antibiotics in preventing surgical wound infections during various surgical procedures. By integrating data from observational studies, cohort studies, and randomized controlled trials (RCTs), this review seeks to demonstrate the impact of prophylactic antibiotic use in reducing the incidence of both superficial and deep surgical wound infections when compared to placebo or no antibiotics. The investigation will examine the effectiveness of different antibiotic regimens as well as the optimal timings, dosages, and durations of antibiotic administration. Additionally, the evaluation will examine the impact of patient-related factors, such as comorbidities, on the effectiveness of prophylaxis. The primary outcome will be the rate of surgical wound infections, with the length of hospital stay, adverse events, and medical costs acting as secondary outcomes. By addressing the gaps in current clinical practice, this review will offer evidence-based recommendations for the use of prophylactic antibiotics in surgical settings. Future clinical guidelines and practices will be guided by these suggestions in an effort to enhance patient outcomes and reduce healthcare expenses

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Published

2025-01-28

How to Cite

1.
Pratap Dhimar C, Vaishnaw A. Assessing the role of prophylactic antibiotics in surgical site infections: a systematic review and meta-analysis. J Neonatal Surg [Internet]. 2025Jan.28 [cited 2025Feb.14];14(1S):102-9. Available from: https://jneonatalsurg.com/index.php/jns/article/view/1501

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