Association between Iron Deficiency Anemia and Preterm Labour among Pregnant Women in the population under study
Keywords:
Iron deficiency anemia, preterm labour, pregnancy, maternal health, risk factorsAbstract
Background:Iron deficiency anemia is a common condition in pregnancy and has been associated with adverse maternal and neonatal outcomes. Its role as a risk factor for preterm labour is of particular concern, especially in low‑resource settings.
Objective:To determine the association between iron deficiency anemia and preterm labour among pregnant women.
Study design: Case control study
Duration and Place of study: This study was conducted in Sir Ganga Ram Hospital Lahore from January 2024 to June 2024
Methods :A total of 60 pregnant women were recruited using a non‑probability consecutive sampling technique. The study included 30 cases presenting with preterm labour and 30 controls presenting with term labour. Detailed clinical and obstetric histories were taken, and venous blood samples were collected to assess haemoglobin and ferritin levels. Anemia was defined as a haemoglobin level of <10 g/dL. Odds ratios (OR) with 95% confidence intervals were calculated, and data were analysed using SPSS version 20.0.
Results:The mean age of participants was 28.51±4.76 years, with a mean gestation of 32.50±1.94 weeks in cases and 39.20±1.56 weeks in controls. The mean haemoglobin level was significantly lower in the preterm labour group (8.40±1.71 g/dL) compared to the term labour group (10.10±2.02 g/dL). Anemia was observed in 63.9% of preterm labour cases versus 36.1% of controls, yielding an OR of 4.29 (95% CI), indicating a significant association between maternal anemia and preterm labour.
Conclusion: The study confirms that maternal iron deficiency anemia is significantly associated with an increased risk of preterm labour. Early screening, timely treatment, and targeted antenatal interventions may reduce the incidence of preterm births and improve maternal–neonatal outcomes
Downloads
Metrics
References
Goldenberg RL, et al. The preterm birth syndrome. Obstet Gynecol. 2008;111(3):529–539.
Blencowe H, et al. Preterm birth–associated complications and global mortality. Lancet. 2012;379(9832):2162–72.
Lawn JE, et al. 4 million neonatal deaths: when? where? why? Lancet. 2005;365(9462):891–900.
World Health Organization. The global prevalence of anaemia in 2011. Geneva: WHO; 2015.
Balarajan Y, et al. Anaemia in low income and middle income countries. Lancet. 2011;378(9799):2123–35.
Scholl TO. Maternal iron status and pregnancy outcomes. Am J Clin Nutr. 2005;81(5):1217–22.
Klebanoff MA, et al. Anemia and risk of preterm delivery. Am J Epidemiol. 1991;134(3):281–90.
Haider BA, et al. Anemia, prenatal iron use, and risk of preterm delivery. Ann Nutr Metab. 2013;63(3):113–22.
Alizadeh R, et al. Maternal anemia and risk of preterm birth. J Obstet Gynaecol. 2007;27(8):748–51.
Xiong X, et al. Maternal anemia and pregnancy outcomes: a meta-analysis. Am J Clin Nutr. 2000;71(5):1298–304.
Romero R, et al. Infection and preterm labour. Ann N Y Acad Sci. 2001;943:216–22.
Allen LH. Anemia and iron deficiency affect pregnancy outcome. Am J Clin Nutr. 2000;71(5):1280S–1284S.
McClure EM, Goldenberg RL. Infection and preterm birth. Ann Rev Mater Fetal Med. 2009;15(2):201–15.
Ahmad F, et al. Association between maternal iron deficiency anemia and preterm labour. Pak J Med Sci. 2018;34(3):543–7.
Khalid A, et al. Maternal anemia and its association with preterm delivery. J Obstet Gynaecol. 2019;35(1):15–8.
Steer PJ. Maternal hemoglobin concentration and birth weight. Am J Clin Nutr. 2000;71(5):1285S–1287S.
Levy A, et al. Maternal anemia during pregnancy and risk of preterm delivery. Eur J Obstet Gynecol Reprod Biol. 2009;143(2):93–7.
Goldenberg RL, et al. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75–84.
World Health Organization. Iron and folic acid supplements in pregnancy. Geneva: WHO; 2012.
Scholl TO, Hediger ML, Schall JI, Fischer RL, Khoo CS. Anemia vs iron deficiency: increased risk of preterm delivery in the first two trimesters of pregnancy. Am J Clin Nutr. 1992;55(5):985–988.
Xiong X, Buekens P, Fraser WD, Luo Z. Anemia during pregnancy and birth outcomes: a meta analysis. Am J Perinatol. 2000;17(3):137–146.
Khalid A, Aftab A, Khan A. Association between maternal iron deficiency anemia and preterm delivery. Pak J Med Sci. 2018;34(3):543–547.
Haider BA, Olofin I, Wang M, Spiegelman D, Ezzati M, Fawzi WW. Anaemia, prenatal iron use, and risk of preterm delivery: systematic review and meta analysis. Ann Nutr Metab. 2013;63(3):113–122.
Levy A, Fraser D, Rosen HE, Dagan R, Yuval D. Maternal anemia and pregnancy outcomes. Eur J Obstet Gynecol Reprod Biol. 2009;143(2):93–97.
Allen LH. Anemia and iron deficiency in pregnancy. Am J Clin Nutr. 2000;71(5):1280S–1284S.
Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75–84.
McClure EM, Goldenberg RL. Infection and preterm birth. Ann N Y Acad Sci. 2009;1153:168–176.
Balarajan Y, Ramachandran A, Subramanian SV. Anemia in low income and middle income countries. Lancet. 2011;378(9799):2123–2135.
Alizadeh R, Mahmoudzadeh A, Aghamolaei T. Maternal anemia and its association with pregnancy outcomes. J Obstet Gynaecol. 2007;27(8):748–751.
Allen LH, Casterline Sabelha J. Anemia and placentation in early pregnancy. Am J Clin Nutr. 2008;88(2):421S–427S.
Franchi M, et al. Early pregnancy iron therapy improves placentation and reduces risk of preterm delivery. Eur J Clin Nutr. 2011;65(1):89–95
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.