Assessment Of Tissue Healing Property Of Gel Of Urtica Dioica L. And Xanthium Strumarium L. Against The Excision And Incision Wound Model In Rats

Authors

  • Swati Trivedi
  • Ashish Manigaunha

Keywords:

Urtica dioica, Xanthium strumarium, excision and incision wound model

Abstract

Urtica dioica L., a long lasting herb found in South Asia, is utilized for the treatment of many ailments owing to its antioxidant and antibacterial characteristics. Xanthium strumarium L., originating from North America, Europe, and Asia, possesses anti-inflammatory, antioxidant, and antibacterial characteristics. Furthermore, it has been examined for its potential in treating cancer, and certain molecules have demonstrated cytotoxic properties. Additional research is required in order to comprehensively comprehend their therapeutic uses. The aim of study to assess the tissue injury healing properties of a gel that contains Xanthium strumarium L. and Urtica dioica L. The evaluation was conducted using rat models of excision and incision wounds. The objective set for study to find out the immediate harmful reaction on the skin caused due to gel formulations used for promoting wound healing. The rats underwent depilation using a razor blade and were then left undisturbed for a duration of 24 hours. Following a 24- hour period, the experimental medicine was administered to the shaved areas, whereas the control group got a local application of sterile water on skin. The medication was administered consecutively for a duration of 14 days, with daily monitoring for any alterations in the patient's clinical condition. There were no negative clinical changes observed. The study assessed the immediate skin toxicity of gel formulations used for wound healing in rats. Following a 24-hour period, the experimental medicine was administered to the shaved areas, whereas the control group was given sterile water. The study saw no detrimental clinical alterations. The gel formulation of Xanthium strumarium L. exhibited superior tensile strength and a shorter epithelization period in comparison to the control group. The gel formulation exhibited superior histopathological recovery. Reactive oxygen species levels were comparable to those in the usual therapy group.

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References

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Published

2025-08-06

How to Cite

1.
Trivedi S, Manigaunha A. Assessment Of Tissue Healing Property Of Gel Of Urtica Dioica L. And Xanthium Strumarium L. Against The Excision And Incision Wound Model In Rats. J Neonatal Surg [Internet]. 2025Aug.6 [cited 2025Sep.21];13(1):770-6. Available from: https://jneonatalsurg.com/index.php/jns/article/view/8754

Issue

Vol. 13 (2024): Journal of Neonatal Surgery

Section

Original Article

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