Association Of Type 2 Diabetes Mellitus in Patients with Cholelithiasis in A Tertiary Care Centre – Chengalpattu District
Keywords:
cholelithiasis/gallstone disease (GD), diabetes mellitus, dyslipidaemia, obesity, risk factorAbstract
Objectives: Cholelithiasis is becoming more prevalent in developing countries like India with huge financial burden and it has many risk factors, such as age, sex, dyslipidaemia, diabetes mellitus (DM), and obesity. It is characterized by the formation of gallstones in the hepatic bile duct, common bile duct, or gallbladder. The aim of this study is to assess the prevalence and to establish the association between diabetes and gallstone disease.
Materials & Methods: This retrospective study using descriptive cross-sectional design, enrolled patients with gallstones attending Karpaga Vinayaga Institute of Medical Sciences, a tertiary care hospital in Chengalpattu District. All patients with cholelithiasis from ultrasound abdomen were enrolled in this study
Results: 113 subjects were selected through consecutive sampling, wherein 65.5% were female and 34.5% were male with 77.9% aged more than 40 years. The majority had obesity grade II with mean BMI 26.5 kg/m2 for males and 27.4 kg/m2 for females. Dyslipidaemia was found in 85 subjects with proportion of high total cholesterol was 84.5%, high LDL 90.9%, high triglycerides 73.3%, and low HDL 56.2%. DM was found in 65(57.5%) subjects. Female and age > 40 years had more proportion in cholelithiasis patients namely 77.9 %.
Conclusion:
In this study, we concluded that there is a higher prevalence of T2DM in cholelithiasis patients, and hence there is an association between cholelithiasis and T2DM. This study also reiterated the association between obesity and gallstone disease(GD). Female sex and advancing age also contribute to the formation of cholelithiasis. Patients with obesity grade II, high LDL and high PPBS should be considered at risk for cholelithiasis
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