Development and Assessment of Copper Nanoparticles Synthesized from Wild carrot. Leaf Extract for Cancer Therapy
DOI:
https://doi.org/10.63682/jns.v14i32S.7592Keywords:
Copper nanoparticles, leaf extract, Wild carrot, CancerAbstract
All over the world, Cancer is the most fatal disease. Various forms of cancer can be treated with a variety of medication groups. The leaves extract of Wild carrot was used in this study to formulate Copper nanoparticles utilizing a Green synthetic method. NPS were successfully synthesized using the Copper Sulphate Solution as the precursor of copper and leaf extract Wild carrot of the 50 ml (5 mm) of CuSO4 was stimulated to react using the plant extracts. The nanoparticles exhibited a cuboidal shape and had an average size of 36.7nm, 53.5nm and 75.6 nm. FTIR spectrum analysis shows absorption peak of copper nanoparticles bonding among 1509-3917cm-1. In the SEM, the particle shape was found to be Cuboidal. The results showed that the copper nanoparticles demonstrated significant anticancer potential with a GI50 value of >80ug/ml of plant and copper nanoparticles. As compare to standard drug with a GI50 value of <10ug/ml a strong inhibitory effect on the cancer cells.
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Das PE, Abu-Yousef IA, Majdalawieh AF, Narasimhan S, Poltronieri P. Green synthesis of encapsulated copper nanoparticles using a hydroalcoholic extract of Moringa oleifera leaves and assessment of their antioxidant and antimicrobial activities. Molecules. 2020 Jan 28;25(3):555.
Dashtizadeh Z, Kashi FJ, Ashrafi M. Phytosynthesis of copper nanoparticles using Prunus mahaleb L. and its biological activity. Materials Today Communications. 2021 Jun 1;27:102456.
Debela DT, Muzazu SG, Heraro KD, Ndalama MT, Mesele BW, Haile DC, Kitui SK, Manyazewal T. New approaches and procedures for cancer treatment: Current perspectives. SAGE open medicine. 2021 Aug;9:20503121211034366.
Devi RS, Jeevitha M, Preetha S, Rajeshkumar S. Free radical scavenging activity of copper nanoparticles synthesized from dried ginger. Journal of Pharmaceutical Research International. 2020;32:1-7.
Kumar D, Gupta, V, Tanwar, R. et al. From skin to bone: sun avoidance and osteoarthritis risk. Rheumatol Int 45, 146 (2025). https://doi.org/10.1007/s00296-025-05904-5
Kumari P, Khatkar A, Rani P, Khatkar S, Nandal R. Optimizing the Microwave-Assisted Extraction Method to Enhance Extraction Yield and Total Phenolic Content from Moringa Leaves (Moringa oleifera Lam.). Cuestiones de Fisioterapia. 2024 Dec 3;53(03):464-82.
Kumari P, Nandal R, Rani P, Rathi P, Khatkar S, Khatkar A. In Silico Screening of Phytoconstituents and Medicinal Plants as Antidiabetic Drug Discovery. Corrosion Management ISSN: 1355-5243. 2024;34(2):227-45.
Liu H, Wang G, Liu J, Nan K, Zhang J, Guo L, Liu Y. Green synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma. Journal of Experimental Nanoscience. 2021 Dec 15;16(1):410-23.
Mali SC, Dhaka A, Githala CK, Trivedi R. Green synthesis of copper nanoparticles using Celastrus paniculatus Willd. leaf extract and their photocatalytic and antifungal properties. Biotechnology Reports. 2020 Sep 1;27:e00518.
Pei J, Fu B, Jiang L, Sun T. Biosynthesis, characterization, and anticancer effect of plant-mediated silver nanoparticles using Coptis chinensis. International Journal of Nanomedicine. 2019 Mar 15:1969-78.
Rani P, Pahwa R, Verma V, Bhatia M. Preparation, characterization, and evaluation of ketoconazole-loaded pineapple cellulose green nanofiber gel. International journal of biological macromolecules. 2024 Mar 1;262:130221.
Rani P, Verma V, Kumar S, Bhatia M. Isolation, characterization and evaluation of pineapple crown waste nanofiber gel entrapping ampicillin in topical bacterial infections. Iranian Polymer Journal. 2024 May;33(5):687-98.
Sarkar S, Kotteeswaran V. Green synthesis of silver nanoparticles from aqueous leaf extract of Pomegranate (Punica granatum) and their anticancer activity on human cervical cancer cells. Advances in Natural Sciences: Nanoscience and Nanotechnology. 2018 Jun 6;9(2):025014.
ShanmugaSundaram C, Sivakumar J, Kumar SS, Ramesh PL, Zin T, Rao UM. Antibacterial and anticancer potential of Brassica oleracea var acephala using biosynthesised copper nanoparticles. The Medical Journal of Malaysia. 2020 Nov;75(6):615.
Tahvilian R, Zangeneh MM, Falahi H, Sadrjavadi K, Jalalvand AR, Zangeneh A. Green synthesis and chemical characterization of copper nanoparticles using Allium saralicum leaves and assessment of their cytotoxicity, antioxidant, antimicrobial, and cutaneous wound healing properties. Applied organometallic chemistry. 2019 Nov;33(12):e5234.
Valsalam S, Agastian P, Arasu MV, Al-Dhabi NA, Ghilan AK, Kaviyarasu K, Ravindran B, Chang SW, Arokiyaraj S. Rapid biosynthesis and characterization of silver nanoparticles from the leaf extract of Tropaeolum majus L. and its enhanced in-vitro antibacterial, antifungal, antioxidant and anticancer properties. Journal of Photochemistry and Photobiology B: Biology. 2019 Feb 1;191:65-74.
Vanaja D, Kavitha S. A study on phytochemicals, antioxidant activity and ft-ir analysis of Rhapis excelsa (thunb.) A. Henry. Eur J Pharm Med Res. 2016;3(7):390-4.
Verma M, Deep A, Nandal R, Shinmar P, Kaushik D. Novel drug delivery system for cancer management: A review. Current Cancer Therapy Reviews. 2016 Dec 1;12(4):253-72.
Vijayakumar G, Kesavan H, Kannan A, Arulanandam D, Kim JH, Kim KJ, Song HJ, Kim HJ, Rangarajulu SK. Phytosynthesis of copper nanoparticles using extracts of spices and their antibacterial properties. Processes. 2021 Jul 30;9(8):1341
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