Assessment Of Sleep Quality and Its Impact on Health-Related Quality of Life in Treated Tuberculosis Patients in A Tertiary Care Centre, Chengalpattu District
DOI:
https://doi.org/10.63682/jns.v14i32S.7463Keywords:
Tuberculosis, Sleep quality, Health-related quality of life, Pittsburgh Sleep Quality Index, SF-36 QuestionnaireAbstract
Introduction: Tuberculosis (TB) can cause persistent symptoms, such as sleep disturbances, even after treatment, significantly reducing the patient’s quality of life. As good sleep is vital for overall health, early identification and management of poor sleep quality are essential for improving long-term outcomes in TB survivors.
Aim: To determine the sleep quality among treated TB patients and to assess its impact on health-related quality of life in a tertiary care centre.
Methods: A cross-sectional study was conducted involving 60 patients with pulmonary and extrapulmonary TB who completed ATT for 6 months. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and HRQoL was evaluated using the SF-36 Questionnaire. Statistical analyses were performed to determine the correlation between PSQI scores and various HRQoL domains.
Results:The mean age was 39.7 years, and 61.7% of patients were male. No significant sex differences were observed (p = 0.254). A total of 35% had poor sleep quality (PSQI > 5), which was significantly more common in those aged > 50 years (p = 0.007). Poor sleepers had notably worse scores in pain, general health, energy/fatigue, and physical functioning (all p < 0.05), with strong negative correlations between PSQI and pain (r = -0.794), physical functioning (r = -0.669), and energy/fatigue (r = -0.635) scores.
Conclusion: Sleep disturbances are common among Treated TB patients and are strongly associated with a reduced quality of life. Integrating routine sleep quality screening and psychosocial support into post-treatment care may improve long-term outcomes for TB survivors.
Downloads
Metrics
References
World Health Organization. Global Tuberculosis Report 2024. World Health Organization, 29 Oct. 2024. https://www.who.int/teams/global-programme-on-tuberculosis-and-lung-health/tb-reports/global-tuberculosis-report-2024.
Dos Santos APC, Lazzari TK, Silva DR. Health-related quality of life, depression and anxiety in hospitalized patients with tuberculosis. Tuberc Respir Dis (Seoul) 2017;80:69–76. https://doi.org/10.4046/trd.2017.80.1.69.
Garbarino S, Lanteri P, Bragazzi NL, Magnavita N, Scoditti E. Role of sleep deprivation in immune-related disease risk and outcomes. Commun Biol 2021;4:1304. https://doi.org/10.1038/s42003-021-02825-4.
Layek A, Suri TM. Tuberculosis and sleep - An underexplored association Indian J Tuberc 2025;72 Suppl 1:S91–3. https://doi.org/10.1016/j.ijtb.2025.02.007.
Sharma N, Ahmed S. Structural and functional pulmonary impairment in treated cases of pulmonary tuberculosis: a cross-sectional study. Med J Armed Forces India 2022;78:151–6. https://doi.org/10.1016/j.mjafi.2020.06.010.
Itagi ABH, Dipankar SP, Krishna Veni D, Yunus GY. Evaluation of spirometric measures and quality of sleep in tuberculosis patients and their non-tuberculosis family caregivers. Cureus 2021;13:e17788. https://doi.org/10.7759/cureus.17788.
Yasobant S, Nazli Khatib M, Syed ZQ, Gaidhane AM, Shah H, Narkhede K, et al. Health-related quality of life (HRQoL) of patients with tuberculosis: A review. Infect Dis Rep 2022;14:509–24. https://doi.org/10.3390/idr14040055.
Itagi ABH, Dharmalingam A, Yunus GY, Velou SM, Subramanian SK, Sundareswaran L. Comparative assessment of depression, quality of sleep, and respiratory functions among tuberculosis patients with their nontuberculosis family contacts. Ind J Respir Care 2021;10:312–7. https://doi.org/10.4103/ijrc.ijrc_54_21.
Pokam BDT, Fokam P, Njamen TN, Guemdjom PW, Asuquo AE. Assessment of health-related quality of life of tuberculosis patients in Fako division, south-west region of Cameroon. J Tuberc Res 2020;08:93–110. https://doi.org/10.4236/jtr.2020.83009.
McHorney CA, Ware JE Jr, Rachel Lu JF, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med Care 1994;32:40–66. https://doi.org/10.1097/00005650-199401000-00004.
Ware J, Snow K, Kosinski M, Gandek B, Ware JE, Sherbourne CD. Medical outcomes study questionnaire short form 36 health survey (SF-36). Med Care. 1994;32(306):1-5. https://www.brandeis.edu/roybal/docs/SF-36_website_PDF.pdf.
Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193–213. https://doi.org/10.1016/0165-1781(89)90047-4.
Liu X, Lan H, Bai X, Li Q, Wen Y, Feng M, et al. Sleep quality and its associated factors among patients with tuberculosis: A cross-sectional study. Front Public Health 2022;10:1047425. https://doi.org/10.3389/fpubh.2022.1047425.
Karim F, Islam MA, Chowdhury AMR, Johansson E, Diwan VK. Gender differences in delays in diagnosis and treatment of tuberculosis. Health Policy Plan 2008;23:476–476. https://doi.org/10.1093/heapol/czn027.
Muniyandi M, Rajeswari R, Balasubramanian R, Nirupa C, Gopi PG, Jaggarajamma K, et al. Evaluation of post-treatment health-related quality of life (HRQoL) among tuberculosis patients. Int J Tuberc Lung Dis 2007;11:887–92. https://pubmed.ncbi.nlm.nih.gov/17705955/.
Raj JP, Ramesh N. Quality of sleep among patients diagnosed with tuberculosis-a cross-sectional study. Sleep Breath 2021;25:1369–77. https://doi.org/10.1007/s11325-020-02242-7.
Dujaili JA, Sulaiman SAS, Hassali MA, Awaisu A, Blebil AQ, Bredle JM. Health-related quality of life as a predictor of tuberculosis treatment outcomes in Iraq. Int J Infect Dis 2015;31:4–8. https://doi.org/10.1016/j.ijid.2014.12.004.
Thoker ZA, Madan K, Mittal S, Tiwari P, Shah TH, Mohan A, et al. Clinical profile and quality of life of patients with post-pulmonary tuberculosis sequelae presenting to a tertiary care hospital. Cureus 2023;15:e36354. https://doi.org/10.7759/cureus.36354.
Aggarwal N, Ghosh T, Bhan M, Dwarakanathan V, Sethi P, Meena VP, et al. Post-tuberculosis sequelae and their correlation with quality of life: An observational study at a tertiary care center of north India. bioRxiv 2021. https://doi.org/10.1101/2021.10.04.21264524.
Zhang H, Li A, Jiang Y, Chen W, Wang J, Zhang P, et al. Sleep quality and influencing factors and correlation with T-lymphocyte subpopulation counts in patients with pulmonary tuberculosis: a cross-sectional study. BMC Infect Dis 2022;22. https://doi.org/10.1186/s12879-022-07946-7.
Nurlaela S, Rahardjo S, Jayanti RD. Analysis of the quality of life of tuberculosis patients based on the SF-36 form (case study in Banyumas Regency). Indian J Tuberc 2024;71 Suppl 2:S225–8. https://doi.org/10.1016/j.ijtb.2024.03.003.
Malik M, Nasir R, Hussain A. Health-related quality of life among TB patients: Question Mark on performance of TB DOTS in Pakistan. J Trop Med 2018;2018:2538532. https://doi.org/10.1155/2018/2538532.
Kodical SP, Roy R, Shetty D, Up N, V R, Chand S, et al. Exploring factors influencing the health-related quality of life of tuberculosis patients: a WHOQOL-BREF-based study. Monaldi Arch Chest Dis 2025;95. https://doi.org/10.4081/monaldi.2024.2913.
Atif M, Sulaiman SAS, Shafie AA, Asif M, Sarfraz MK, Low HC, et al. Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study. Health Qual Life Outcomes 2014;12:19. https://doi.org/10.1186/1477-7525-12-19.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
