Staphylococcus aureus and Antibiotic Resistance: Pathogenic Adaptations and the Role of Neutrophils in Host Défense
Keywords:
Antibiotic Resistance, Multi drug resistance, Morbidity and Mortality, MRSA, VRSA, Stewardship, penicillin resistanceAbstract
Clinical implications include limitations in current antibiotic therapies, increased morbidity and mortality, and the need for novel therapeutics. Current and future approaches to managing antibiotic resistance include antibiotic stewardship programs, surveillance and monitoring, research and development, and innovative therapeutic approaches. Future directions include understanding resistance evolution in community settings, optimizing treatment strategies, and developing new antimicrobial agents. Aim of this review study to provide a comprehensive overview of the historical development of antibiotic resistance in Staphylococcus aureus, from the emergence of penicillin resistance to the rise of multidrug-resistant strains such as MRSA, VISA, and VRSA. Clinical ramifications include higher morbidity and mortality, restrictions on the use of existing antibiotic medicines, and the requirement for novel medications. Innovative therapeutic approaches, research and development, surveillance and monitoring, and antibiotic stewardship programs are some of the current and future strategies for managing antibiotic resistance. Prospective avenues of inquiry encompass comprehending the progression of resistance within community environments, refining therapeutic approaches, and creating novel antimicrobial substances. The purpose of this review study is to present a thorough overview of the evolution of antibiotic resistance in Staphylococcus aureus across time, starting with the advent of penicillin resistance and continuing through the emergence of multidrug-resistant strains like MRSA, VISA, and VRSA.
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