Formulation And Assessment Of An Herbal Gel Containing Cymbopogon Citratus For Wound Healing
Keywords:
Cymbopogon citratus, Lemongrass, Herbal gel, Wound healing, Antioxidant activity, DPPH assay, Phytochemical screening, Topical formulation, Carbopol 940, Natural antimicrobialsAbstract
Wound healing is a complex physiological process that can be impaired by infections and inflammation. Conventional therapies often pose risks such as side effects and antimicrobial resistance. In this study, an herbal gel formulation containing Cymbopogon citratus (lemongrass) extract was developed and evaluated for its wound healing potential. The ethanolic extract of Cymbopogon citratus leaves was obtained using Soxhlet extraction and subjected to phytochemical screening, which confirmed the presence of alkaloids, flavonoids, tannins, terpenoids, saponins, and glycosides. Antioxidant activity was assessed by DPPH assay, showing significant radical scavenging potential with an IC₅₀ of 72.5 µg/mL. Three gel formulations containing 1%, 2%, and 3% extract were prepared using Carbopol 940 as the base. Evaluation parameters including pH, viscosity, spreadability, stability, and antimicrobial activity revealed that the 3% formulation demonstrated the best overall characteristics. The study concludes that Cymbopogon citratus gel holds promise as a natural, effective, and stable topical agent for wound healing applications.
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