Benign Yet Alarming: Cystitis Glandularis and Cystica with Gross Hematuria : A Case Report

Authors

  • Randhi Rinaldi
  • Edwin Tobing
  • Christiano Tansol
  • Erna Kristiani

DOI:

https://doi.org/10.63682/jns.v14i32S.6888

Abstract

Introduction: Cystitis glandularis and cystitis cystica are benign proliferative conditions of the bladder mucosa, often arising as a reactive response to chronic irritation or inflammation. While frequently asymptomatic, they can occasionally present with alarming symptoms such as gross hematuria and urinary retention, mimicking malignancy.

Case Presentation: We report the case of a 43-year-old uncircumcised male who presented with acute urinary retention and gross hematuria due to intravesical blood clots. Physical examination revealed suprapubic fullness and a mildly enlarged prostate. A three-way Foley catheter with manual irrigation was required for decompression. Cystoscopic examination showed multiple raised mucosal lesions and pseudopolyps with active bleeding in the posterior bladder wall. Histopathological analysis of the bladder biopsy confirmed the diagnosis of cystitis glandularis and cystitis cystica. The patient was managed conservatively with non-steroidal anti-inflammatory drugs (NSAIDs), bladder irrigation, and increased hydration.

Conclusion: Although benign, cystitis glandularis and cystitis cystica can present with severe urological symptoms such as hematuria with clot retention. Prompt evaluation with cystoscopy and biopsy is essential to exclude malignancy. Conservative management is often effective, but ongoing surveillance is recommended due to the potential for recurrence and the rare risk of malignant transformation.

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References

Ahmad A, Imbisat MZ, Ranjan N, Tiwari RK, Kumar B, Khatoon Q. Cystitis glandularis- rare cause of urinary bladder mass: case report and literature review. African Journal of Urology [Internet]. 2022 Dec 1 [cited 2025 May 22];28(1):1–5. Available from: https://link-springer-com.unpad.idm.oclc.org/articles/10.1186/s12301-022-00279-6

Liu X, Chen Z, Ye Z. Etiological study on cystitis glandularis caused by bacterial infection. Journal of Huazhong University of Science and Technology - Medical Science [Internet]. 2007 Dec 1 [cited 2025 May 22];27(6):678–80. Available from: https://link-springer-com.unpad.idm.oclc.org/article/10.1007/s11596-007-0615-y

Capozza N, Collura G, Nappo S, De Dominicis M, Francalanci P, Caione P. Cystitis glandularis in children. BJU Int [Internet]. 2005 Feb 1 [cited 2025 May 22];95(3):411–3. Available from: /doi/pdf/10.1111/j.1464-410X.2005.05311.x

Cystitis glandularis: A controversial premalignant lesion [Internet]. [cited 2025 May 22]. Available from: https://www.spandidos-publications.com/10.3892/ol.2014.2360

Wiener DP, Koss LG, Sablay B, Freed SZ. The Prevalence and Significance of Brunn’s Nests, Cystitis Cystica and Squamous Metaplasia in Normal Bladders. J Urol [Internet]. 1979 Sep 1 [cited 2025 May 22];122(3):317–21. Available from: https://www-sciencedirect-com.unpad.idm.oclc.org/science/article/abs/pii/S0022534717563843

Bastianpillai C, Warner R, Beltran L, Green J. Cystitis cystica and glandularis producing large bladder masses in a 16-year-old boy. JRSM Open [Internet]. 2018 Mar [cited 2025 May 22];9(3):205427041774606. Available from: https://scholar.google.com/scholar_url?url=https://journals.sagepub.com/doi/pdf/10.1177/2054270417746060&hl=en&sa=T&oi=ucasa&ct=ufr&ei=MB4uaPXeEZmD6rQPm8iIuAU&scisig=AAZF9b8GlEmD3phT6Qhjs7DtrVH6

Li Z, Liu P, Zu X, Fan B. Progression of research into the diagnosis and treatment of cystitis glandularis: a narrative review. J Xiangya Med [Internet]. 2022 Sep 1 [cited 2025 May 22];7(0). Available from: https://jxym.amegroups.org/article/view/8458/html

Agrawal A, Kumar D, Jha AA, Aggarwal P. Incidence of adenocarcinoma bladder in patients with cystitis cystica et glandularis: A retrospective study. Indian Journal of Urology [Internet]. 2020 Oct 1 [cited 2025 May 22];36(4):297–302. Available from: https://journals.lww.com/indianjurol/fulltext/2020/36040/incidence_of_adenocarcinoma_bladder_in_patients.11.aspx

Son Y, Madison I, Scali J, Chialastri P, Brown G, Son Y, et al. Cystitis Cystica Et Glandularis Causing Lower Urinary Tract Symptoms in a 29-Year-Old Male. Cureus [Internet]. 2021 Aug 13 [cited 2025 May 22];13(8). Available from: https://www.cureus.com/articles/66472-cystitis-cystica-et-glandularis-causing-lower-urinary-tract-symptoms-in-a-29-year-old-male

Yuksel OH, Urkmez A, Erdogru T, Verit A. The role of steroid treatment in intractable cystitis glandularis: A case report and literature review. Canadian Urological Association Journal [Internet]. 2015 May 1 [cited 2025 May 22];9(5–6):E306. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4439231/

Huang Y, Liu D, Jiang L, Liu S. Assessment of cystitis glandularis by transvaginal sonography in women. Journal of Ultrasound in Medicine [Internet]. 2012 Jul 1 [cited 2025 May 22];31(7):1025–31. Available from: /doi/pdf/10.7863/jum.2012.31.7.1025

Kovylina М V., Prilepskaya ЕА, Tsybulya ОA, Tupikina N V., Reva IА, Makhmudov TB. Cystitis cystica and cystitis glandularis: its relationship to the development of urothelial bladder cancer. Cancer Urology [Internet]. 2015 Dec 30 [cited 2025 May 22];11(4):51–3. Available from: https://oncourology.abvpress.ru/oncur/article/view/479

Kim JY, Han D, Kim H, Jung M, Ryu HS. The proteomic landscape shows oncologic relevance in cystitis glandularis. J Pathol Transl Med [Internet]. 2022 Dec 22 [cited 2025 May 22];57(1):67–74. Available from: https://synapse.koreamed.org/articles/1516080847

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Published

2025-06-16

How to Cite

1.
Rinaldi R, Tobing E, Tansol C, Kristiani E. Benign Yet Alarming: Cystitis Glandularis and Cystica with Gross Hematuria : A Case Report. J Neonatal Surg [Internet]. 2025Jun.16 [cited 2025Jul.20];14(32S):399-402. Available from: https://jneonatalsurg.com/index.php/jns/article/view/6888