Formulation and in-vitro characterization of curcumin loaded microsphere hydrogel for the management of vitiligo
DOI:
https://doi.org/10.63682/jns.v14i25S.6218Keywords:
Vitiligo, Curcumin, Microsphere, Hydrogel, In-vitro Characterization, Drug deliveryAbstract
Vitiligo is a chronic skin disorder characterized by the progressive loss of melanocytes, leading to depigmented patches. Conventional treatments often face limitations such as incomplete repigmentation and adverse effects. Curcumin, a natural polyphenolic compound derived from Curcuma longa, has shown promising antioxidant, anti-inflammatory, and melanogenic activities, making it a potential therapeutic agent for vitiligo. However, its clinical application is hindered by poor solubility, stability, and bioavailability.
This study aimed to develop and evaluate a novel curcumin-loaded microsphere hydrogel system for the sustained and localized delivery of curcumin to vitiliginous skin. Curcumin-loaded microspheres were prepared using the solvent evaporation technique, characterized for particle size, morphology, encapsulation efficiency, and drug loading. These microspheres were then incorporated into a Carbopol-based hydrogel, which was further evaluated for pH, viscosity, spreadability, swelling index, and in-vitro drug release behavior.
The formulated microspheres exhibited uniform spherical morphology with high encapsulation efficiency, while the hydrogel demonstrated desirable physicochemical properties suitable for topical application. In-vitro drug release studies indicated a sustained release profile, following Higuchi kinetics, suggesting effective drug retention and controlled delivery.
In conclusion, the curcumin-loaded microsphere hydrogel system offers a promising approach for the topical management of vitiligo, potentially enhancing therapeutic efficacy while minimizing systemic side effects.
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