A Complex Case of Rhupus Syndrome with Vogt-Koyanagi-Harada Syndrome in a Patient with Type 2 Diabetes Mellitus: A Therapeutic Challenge and Multidisciplinary Approach
Keywords:
Vogt-Koyanagi-Harada (VKH) syndrome, Rhupus syndrome, Systemic lupus, erythematosus (SLE), Rheumatoid arthritis (RA), Autoimmune disorders, Bilateral diffuse uveitis, Visual impairmentsAbstract
Vogt-Koyanagi-Harada Syndrome (VKH) syndrome is a autoimmune disorder affecting melanin-pigmented tissues, with significant ocular manifestation, ear, skin, and central nervous system. We report a rare patient with a VKH Associated With Rhupus syndrome.
Case Report
49-year-old lady with a history of type 2 diabetes mellitus presented with abdominal pain, breathlessness, and visual impairments. Diagnostic evaluation confirmed VKH syndrome, characterized by bilateral diffuse uveitis and other systemic involvements.. Further investigations revealed an overlap syndrome of SLE and RA, commonly known as Rhupus syndrome, complicating her clinical course. The patient was treated with intravenous methylprednisolone, mycophenolate mofetil, and oral prednisone, leading to significant improvement in ocular symptoms and visual acuity
Conclusion
This case underscores the complexity of diagnosing and managing patients with multiple overlapping autoimmune disorders.
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References
A Rare Case of Rhupus Syndrome With Systemic Involvement: A Case Report and Literature.
Mohammad S. Dairi, Deema S. Ashoor , Ahad S. Babkier , Rami Algahtani , Khaled S. Dairi. 2022.
Rhupus syndrome. a case report of a rare combination. Tasneem Drie, MD,, Naram Khalayli, MD, Ghina Haidar, MD, Diaa Haj Ali, MD. s.l. : Drie et al. Annals of Medicine & Surgery (2024), 2024. 86:535–538.
Rhupus Syndrome: Overlap of Rheumatoid Arthritis and Systemic Lupus Erythematosus. Hussain M*, Ijaz Y, Ahmed D, Tipu HN, Alam M. 1-2021, s.l. : Austin J clin immunol, 2021, Vol. 7. 2381-9138.
Clinical Features and Histopathological Findings in Rhupus Patients Developing Glomerulonephritis in Arzobispo Loayza Nacional Hospital Between 2003 and 2009. Gissela Suárez Pichilingue1, Jorge Gutierrez Campos2, Javier Cieza Zevallos. s.l. : Acta Med Per, 2011, Vol. 28(2)
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