The Potential Therapeutic Role of EGCG (Epigallocatechin-3-Gallate) in Diabetes Progression
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N\AAbstract
Diabetes mellitus is a complex and widespread metabolic disorder that continues to pose significant health challenges worldwide. While existing treatments help manage blood sugar levels, they often fail to fully address the underlying causes and long-term complications of the disease. Epigallocatechin-3-gallate (EGCG), a powerful antioxidant found in green tea, has attracted growing interest for its potential role in slowing diabetes progression. Research suggests that EGCG may help improve insulin sensitivity, protect pancreatic β-cells, reduce inflammation, and regulate glucose metabolism—factors that are central to both Type 1 and Type 2 diabetes. It also interacts with key cellular pathways, including AMPK, PI3K/Akt, and NF-κB, which are involved in maintaining metabolic balance. Studies in animal models and early clinical trials have shown promising results, but challenges such as low bioavailability and limited long-term human data remain. New approaches like nanoformulations are being explored to improve how EGCG is absorbed and used in the body. Overall, EGCG shows promise as a supportive therapy for diabetes, though more rigorous human studies are needed to better understand its full potential and ensure its safe use.
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