Antidiabetic Potential of Andrographis Echioides in Streptozotocin-Induced Diabetic Rats

Authors

  • K Kavitha
  • Shankar D E
  • Chainesh Shah

Keywords:

Andrographis echioides, hypoglycemic, fasting blood glucose, lipid profiles, streptozotocin

Abstract

The present study was designed to investigate the hypoglycemic effect of the methanol extract of Andrographis echioides (MEAE) in streptozotocin (STZ)-induced diabetic Wistar rats. Diabetes was induced via a single intraperitoneal injection of STZ at a dose of 55 mg/kg body weight. After three days of induction, hyperglycemic rats were orally administered MEAE at doses of 200, 500, and 800 mg/kg body weight daily for 21 days. Glibenclamide (1 mg/kg, orally) was used as the reference standard. Fasting blood glucose levels were measured on days 7, 14, and 21, along with the evaluation of serum biochemical parameters, including lipid profile. TMEAE treatment resulted in a significant (P < 0.01) and dose-dependent reduction in fasting blood glucose levels, the dose 800 mg/kg being the most potent showing complete normalization of blood glucose levels. Also, MEAE significantly (P < 0.01) restored the diabetic rats' unusual lipid profiles and other serum biochemical markers to normal. In STZ-induced diabetic rats, Andrographis echioides showed promising hypoglycemic action, supporting its ethnomedical use, according to the results

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Published

2025-05-02

How to Cite

1.
K Kavitha KK, D E S, Shah C. Antidiabetic Potential of Andrographis Echioides in Streptozotocin-Induced Diabetic Rats. J Neonatal Surg [Internet]. 2025May2 [cited 2025Sep.21];14(16S):1041-7. Available from: https://jneonatalsurg.com/index.php/jns/article/view/4982

Issue

Vol. 14 No. 16S (2025): Journal of Neonatal Surgery

Section

Original Article

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