Therapeutic Prospects Of Ocimum Sanctum And Piper Betel Leaves In Cancer Management: A Review
DOI:
https://doi.org/10.63682/jns.v14i17S.4689Keywords:
Ocimum sanctum, Piper betel, Tulsi, Cancer cell linesAbstract
The present review is on the potential therapeutic uses of the main phytoconstituents of Ocimum sanctum species and Piper betel leaves, as an anticancer drugs for a range of cancer forms. Tulsi and betel leaves have been more widely recognized in recent years because of its anticancer qualities. Many plant components from these plants are being tested for possible anticancer benefits in ongoing clinical trials. It was found to be active against some of the cancer cell lines that include those from OSCC (oral squamous cell carcinoma), Ehrlich ascites carcinoma, breast cancer, hepatocellular carcinoma, human ovarian carcinoma (SKOV-3) cancer, human gastric adenocarcinoma (AGS), and human gastric cancer cell lines by various assay methods. The naturally-extracted phytochemicals from both plants exhibit the anticancer activity as well as effects on other forms of cancer cell lines.
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Baliga, M. S., & Rao, S. (2010). Radioprotective potential of Ocimum sanctum Linn. and its phytochemicals. Pharmacological Research, 62(3), 322-330.
Prakash, P., & Gupta, N. (2005). Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: A short review. Indian Journal of Physiology and Pharmacology, 49(2), 125-131.
3.Mondal, S., Mirdha, B. R., & Mahapatra, S. C. (2009). The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian Journal of Physiology and Pharmacology, 53(4), 291-306.
Badwaik, R., Biswas, D., & Haldar, P. K. (2021). Cytotoxicity and apoptotic induction in breast cancer cells by Ocimum sanctum Linn. leaf extract. Journal of Cancer Research and Therapeutics, 17(1), 146-153.
Sharma, P., Yadav, S., & Rai, V. K. (2021). Anticancer potential of Ocimum sanctum and its bioactive constituents: In vitro and in vivo studies. Journal of Ethnopharmacology, 271, 113-119.
Gupta, S., & Chauhan, R. (2022). Anti-metastatic effect of Ocimum sanctum in murine lung cancer model. Journal of Experimental Therapeutics and Oncology, 14(2), 101-110.
Singh, N., & Sharma, V. (2021). Quality of life improvement in advanced cancer patients treated with Ocimum sanctum: A pilot study. Integrative Cancer Therapies, 20, 1-9.
Verma, P., & Kumar, A. (2021). Synergistic effects of Ocimum sanctum and conventional chemotherapy in cancer treatment: A clinical perspective. Cancer Medicine, 10(15), 5213-5223.
Pattanayak, P., Behera, P., Das, D., & Panda, S. K. (2010). Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacognosy Reviews, 4(7), 95-105.
Prachi Shivpuje, Renuka Ammanangi, Kishore Bhat, Sandeep Katt. Effect of Ocimum sanctum on Oral Cancer Cell Line: An in vitro Study, The Journal of Contemporary Dental Practice, September 2015;16(9):709-714.
Kusumawadee Utispan, Sittichai Koontongkaew, Nattisa Niyomtham, Boon-ek Yingyongnarongkul. Ethanolic extract of Ocimum sanctum leaf modulates oxidative stress, cell cycle and apoptosis in head and neck cancer cell lines, Heliyon 9 (2023) e15518.
A.M. Luke, R. Patnaik, S.T. Kuriadom, M. Jaber , S. Mathew. An in vitro study of Ocimum sanctum as a chemotherapeutic agent on oral cancer cell-line, Saudi Journal of Biological Sciences, 28 (2021) 887–890.
Taie, H.A.A.; Salama, Z.A.-E.R.; Radwan, S. Potential Activity of Basil Plants as a Source of Antioxidants and Anticancer Agents as Affected by Organic and Bio-organic Fertilization. Not. Bot. Horti Agrobot. Cluj Napoca 2010, 38, 119–127.
Aburjai, T.A.; Mansi, K.; Azzam, H.; Alqudah, D.A.; Alshaer, W.; Abuirjei, M. Chemical Compositions and Anticancer Potential of Essential Oil from Greenhouse-Cultivated Ocimum basilicum Leaves. Indian J. Pharm. Sci. 2020, 82, 179–184.
Doguer, C.; Yıkmı¸s, S.; Levent, O.; Turkol, M. Anticancer effects of enrichment in the bioactive components of the functional beverage of Turkish gastronomy by supplementation with purple basil (Ocimum basilicum L.) and the ultrasound treatment. J. Food Process. Preserv. 2021, 45, e15436.
Hanachi, P.; Fakhrnezhad, F.R.; Zarringhalami, R.; Orhan, I.E. Cytotoxicity of Ocimum basilicum and Impatiens walleriana Extracts on AGS and SKOV-3 Cancer Cell Lines by Flow Cytometry Analysis. Int. J. Cancer Manag. 2021, 14, e102610
Nangia-Makker, P.; Raz, T.; Tait, L.; Shekhar, M.P.V.; Li, H.; Balan, V.; Makker, H.; Fridman, R.; Maddipati, K.; Raz, A. Ocimum gratissimum retards breast cancer growth and progression and is a natural inhibitor of matrix metalloproteases. Cancer Biol. Ther. 2013, 14, 417–427.
Boonyanugomol, W.; Rukseree, K.; Prapatpong, P.; Reamtong, O.; Baik, S.-C.; Jung, M.; Shin, M.-K.; Kang, H.-L.; Lee, W.-K. An In Vitro Anti-Cancer Activity of Ocimum tenuiflorum Essential Oil by Inducing Apoptosis in Human Gastric Cancer Cell Line. Medicina 2021, 57, 784.
Indrayudha, P.; Hapsari, H.S. Cytotoxic activity of combined ethanolic extract of Cinnamomum burmannii and Ocimum tenuiflorum Linn against T47D cancer cells. Arch. Venez. Farmacol. Ter. 2021, 40, 114–120.
Sharma, P.; Prakash, O.; Shukla, A.; Singh Rajpurohit, C.; Vasudev, P.G.; Luqman, S.; Kumar Srivastava, S.; Bhushan Pant, A.; Khan, F. Structure-Activity Relationship Studies on Holy Basil (Ocimum sanctum L.) Based Flavonoid Orientin and Its Analogue for Cytotoxic Activity in Liver Cancer Cell Line HepG2. Comb. Chem. High Throughput Screen. 2016, 19, 656–666.
Ananda Guha Majumdara , Mahesh Subramaniana. Hydroxychavicol from Piper betle induces apoptosis, cell cycle arrest, and inhibits epithelial-mesenchymal transition in pancreatic cancer cells. Biochemical Pharmacology, 2019, 166, 274–291.
Pei-Fang Wu, Hsien-Chun Tseng, Charng-Cherng Chyau, Jing-Hsien Chen and Fen-Pi Chou. Piper betle leaf extracts induced human hepatocellular carcinoma Hep3B cell death via MAPKs regulating the p73 pathway in vitro and in vivo. Food and Function, 2014, 5, 3320–3328.
Sadiya R Veettil, E Anuradha Sunil, Archana Mukunda, Arun Mohan, Shanly John, Meera K Pynadath. Anticancer effect of Piper betle leaf extract on KB cell lines – an in vitro study. Oral and Maxillofacial Pathology Journal, 2022, 13(1) 28-31.
Muskan Tamboli, Naziya Tamboli. Exploration of in-vitro anti-cancer activity of Piper betel linn. Oral and Maxillofacial Pathology Journal.2021, 11(2), 157-165.
V. Radhalakshmi, Maya Raman, Minnu Rose Joy. Protective benefits of ethyl alcohol extract of Piper betel L. to prevent colon carcinogenesis. Pharmacological Research - Natural Products. 2024, 100024.
Supavadee Boontha, Jirapon Taowkaen, Thanaporn Phakwan, Teerapong Worauaichai, Piyarat Kamonnate, Benjaporn Buranrat, Tasana Pitaksuteepong. Evaluation of antioxidant and anticancer effects of Piper betle L (Piperaceae) leaf extract on MCF-7 cells, and preparation of transdermal patches of the extract, Tropical Journal of Pharmaceutical Research June 2019, 18 (6): 1265-1272.
Rajedadram A, Pin KY, Ling SK, Yan SW and Looi ML. Hydroxychavicol, a polyphenol from Piper betle leaf extract, induces cell cycle arrest and apoptosis in TP53-resistant HT-29 colon cancer cells. J Zhejiang Univ Sci B. 2021, 22:112–122.
Gundala SR, Yang C, Mukkavilli R, Paranjpe R, Brahmbhatt M, Pannu V, Cheng A, Reid MD and Aneja R: Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis. Toxicol Appl Pharmacol. 2014, 280:86–96.
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