Evaluation Of Anti-Urolithiasis Potential of Siddha Formulation Mahaboopathiparpam Using Struvite Crystal Growth Inhibition Assay
DOI:
https://doi.org/10.52783/jns.v14.3985Keywords:
Anti-urolithiasis, Siddha formulation, Phytocomponents, Crystals, MahaboopathiparpamAbstract
Abstract: Urolithiasis is a medical term used to describe the formation of stones, known as calculi, within the urinary tract.
It can vary in severity from asymptomatic small stones to large stones causing significant pain, obstruction of urine flow and
potential complications such as urinary tract infections or kidney damage. Preventing the recurrence of urolithiasis poses a
significant challenge, emphasizing the necessity for innovative therapeutic approaches that can effectively inhibit the
formation and initial stages of crystal development.
Objective: The main aim of the present investigation is to explore the anti-urolithiasis potential of siddha formulation
Mahaboopathiparpam using diffusion gel growth technique.
Materials and Methods: Silica hydrogel matrix was divided in to three groups which were control and two MBP treated
groups. Test drug was screened at two dose levels of 0.5% and 1%. The efficiency of the formulations was screened by
comparing the crystal size of the control and treatment medium.
Results: The average size of the crystals in the control medium was found to be 1.4 ± 0.23 cm, whereas the crystal size was
significantly decreased in medium contains 0.5% and 1% of MBP with the size of 1.16 ± 0.15 and 0.74 ± 0.21 cm.
Conclusion: Results clearly indicates that the siddha formulation offers maximum percentage inhibition on the crystal
growth in the tested medium, this efficacy may be due to presence of versatile phytocomponents present in the formulations.
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