Formulation and Characterization of Blend Microspheres of Dexrabeprazole
DOI:
https://doi.org/10.52783/jns.v14.3317Keywords:
Dexrabeprazole, blend microspheres, controlled release, solvent evaporation, polyblend, polylactic acid, polycaprolactone, entrapment efficiency, sustained release, scanning electron microscopyAbstract
Dexrabeprazole blend microspheres were developed using a solvent evaporation technique to achieve controlled drug release
for therapeutic applications. The microspheres were prepared by emulsifying a polyblend solution of polylactic acid (PLA)
and polycaprolactone (PCL) in a polyvinyl alcohol (PVA) solution. The formulations were evaluated for their percentage
yield, entrapment efficiency, flow properties, stability in acidic conditions, and drug release profiles. Among the
formulations, F3 showed the highest entrapment efficiency (82.25%) and an optimal drug release profile with a slow,
sustained release over 12 hours. Scanning electron microscopy (SEM) revealed spherical, smooth microspheres, indicating
well-formed drug carriers. The drug release followed zero-order kinetics, demonstrating the potential of the microspheres
for prolonged drug release. The results suggest that the blend microspheres of Dexrabeprazole are suitable for controlled
release applications, improving therapeutic efficacy and patient compliance.
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