Advance and Emerging Roles of Hydrogel in Promoting Periodontal Tissue Regeneration and Repairing Bone Defect
DOI:
https://doi.org/10.52783/jns.v14.3010Keywords:
N/AAbstract
Aim: This study was conducted to investigate the role of hydrogel on alveolar bone defect repairment of bone defect and promoting periodontal tissue Regeneration
Methods: For this clinical study, we recruited 23 patients (17 females and 6 males with a mean age of 50.3 years) who had moderate to advanced chronic periodontitis. Compromised systemic health condition and no contraindications for periodontal surgery . All study subjects had destruction of periodontal tissue and at least one 1-, 2- or 3-walled bone defect. Before periodontal surgical treatment, each patient received an initial preparatory session, including oral hygiene instruction, scaling, and root planing.
Results: The pre-treatment and post-treatment clinical parameters were evaluate and we compared the values of PPD, CAL, and LBG at 3, 6, and 12 months after treatment with the pre-treatment values. From before treatment to 12 months after treatment, the changes in mean PPD and mean CAL of treated sites were 3.8 ± 1.9 mm and 5.9 ± 2.0 mm, respectively. Also, at 12 months following treatment, hard tissue showed a mean LBG of 3.5 ± 2.1 mm and a mean BF of 61.8 ± 25.2%. The mean depth of bone defects and periodontal tissue regeneration was less at both 6 months and 12 months compared with the pre-treatment mean . These differences were statistically significant
Conclusion: The results demonstrated that the hydrogel successfully delivered periodontal ligament stem cells derived exosomes for repairing alveolar bone defects .
We evaluated the clinical effects of the sustained release of bFGF from gelatin hydrogel for the treatment of periodontal disease with infrabony defects and periodontal tissue regeneration . we obtain clinical attachment gain, probing depth reduction, and radiographic bone fill. We conclude by suggesting that the topical application of gelatin hydrogel in the treatment of chronic periodontitis with infrabony defects or furcation is safe, leads to improvement of clinical parameters, and offers promise as a new avenue for periodontal regeneration.
Downloads
Metrics
References
1S. Harada, G. A. Rodan, Nature 2003, 423, 349.
2A. Stolzing, E. Jones, D. McGonagle, A. Scutt, Mech. Ageing Dev. 2008, 129, 163.
3a) D. D. D'Lima, K. I. Lee, J. S. Lee, K. T. Kang, Y. B. Shim, Y. S. Kim, J. W. Jang, S. H. Moon, Am. J. Sports Med. 2018, 46, NP61;
b) D. Seow, Y. Yasui, E. T. Hurley, A. W. Ross, C. D. Murawski, Y. Shimozono, J. G. Kennedy, Am. J. Sports Med. 2018, 46, 1758;
c) Z. Wang, Y. Wang, Z. Y. Wang, J. S. Gutkind, Z. L. Wang, F. Wang, J. Lu, G. Niu, G. J. Teng, X. Y. Chen, Stem Cells 2015, 33, 456;
d) W. F. Willems, M. Larsen, G. Giusti, P. F. Friedrich, A. T. Bishop, J. Orthop. Res. 2011, 29, 1431.
Amir, M. S., Chiba, N., Seong, C. H., Kusuyama, J., Eiraku, N., Ohnishi, T., et al. (2022). HIF-1α plays an essential role in BMP9-mediated osteoblast differentiation through the induction of a glycolytic enzyme, PDK1. J. Cell. Physiol. 237, 2183–2197. doi:10.1002/jcp.30752
Amiryaghoubi, N., Pesyan, N. N., Fathi, M., and Omidi, Y. (2020). Injectable thermosensitive hybrid hydrogel containing graphene oxide and chitosan as dental pulp stem cells scaffold for bone tissue engineering. Int. J. Biol. Macromol. 162, 1338–1357. doi:10.1016/j.ijbiomac.2020.06.138
Anada, T., Pan, C.-C., Stahl, A. M., Mori, S., Fukuda, J., Suzuki, O., et al. (2019). Vascularized bone-mimetic hydrogel constructs by 3D bioprinting to promote osteogenesis and angiogenesis. Int. J. Mol. Sci. 20, 1096. doi:10.3390/ijms20051096
ASTM (2014). Standard guide for pre-clinical in vivo evaluation in critical size segmental bone defects. Pennsylvania, United States: ASTM International. ASTM F2721-09.
Azevedo, H. S., and Pashkuleva, I. (2015). Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration. Adv. Drug Deliv. Rev. 94, 63–76. doi:10.1016/j.addr.2015.08.003
Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., et al. (2019). Cellular biology of fracture healing. J. Orthop. Res. 37, 35–50. doi:10.1002/jor.24170
Beddoes, C. M., Whitehouse, M. R., Briscoe, W. H., and Su, B. (2016). Hydrogels as a replacement material for damaged articular hyaline cartilage. Mater. (Basel) 9, 443. doi:10.3390/ma9060443
Berendsen, A. D., and Olsen, B. R. (2014). How vascular endothelial growth factor-A (VEGF) regulates differentiation of mesenchymal stem cells. J. Histochem. Cytochem. 62, 103–108. doi:10.1369/0022155413516347
Bose, S., and Tarafder, S. (2012). Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review. Acta Biomater. 8, 1401–1421. doi:10.1016/j.actbio.2011.11.01
Buwalda, S. J., Vermonden, T., and Hennink, W. E. (2017). Hydrogels for therapeutic delivery: Current developments and future directions. Biomacromolecules 18, 316–330. doi:10.1021/acs.biomac.6b01604
Calabrese, G., Giuffrida, R., Fabbi, C., Figallo, E., Lo Furno, D., Gulino, R., et al. (2016). Collagen-hydroxyapatite scaffolds induce human adipose derived stem cells osteogenic differentiation in vitro. PLoS One 11, e0151181. doi:10.1371/journal.pone.0151181
Caplan, A. I., and Correa, D. (2011). PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs. J. Orthop. Res. 29, 1795–1803. doi:10.1002/jor.21462
Charlet, A., Bono, F., and Amstad, E. (2022). Mechanical reinforcement of granular hydrogels. Chem. Sci. 13, 3082–3093. doi:10.1039/d1sc06231j
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
