Body Fat and Hormonal Imbalances in Polycystic Ovary Syndrome: A Comparative Analysis of Treatment Outcomes
DOI:
https://doi.org/10.52783/jns.v14.1834Keywords:
PCOS, BMI, LH/FSH ratio, body fat, hormonal imbalance, personalized therapyAbstract
Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder linked to obesity, insulin resistance, and reproductive dysfunction. Despite various treatments, hormonal imbalances persist, complicating management.
Objective: This study investigates the anthropometric and hormonal profiles of PCOS patients, focusing on LH, FSH, and body composition in treated and untreated groups, compared to healthy controls.
Methods: A total of 30 PCOS patients (15 treated, 15 untreated) and 20 healthy controls were assessed for BMI, body fat percentage, and serum LH/FSH levels using ELISA. Statistical analysis included t-tests and correlation analyses.
Results: PCOS patients had significantly higher LH and lower FSH levels than controls (p<0.05), with no difference between treated and untreated groups. Body fat was elevated in both PCOS groups but did not correlate with hormonal changes. BMI correlated with body fat in controls (r=0.6, p<0.01), but not in PCOS patients.
Conclusion: Hormonal imbalances in PCOS persist despite treatment. Body fat may trigger, but not regulate, PCOS. Personalized therapies targeting deeper mechanisms are needed.
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