Reviewing Evidence-Based Advancements for Critical Surgical Procedures in Neonatal Medicine
Keywords:
neonatal surgery, congenital diaphragmatic hernia, esophageal atresia, necrotizing enterocolitis, Hirschsprung disease, neonatal anesthesiaAbstract
Neonatal surgery stands among the most technically demanding disciplines in all of medicine, performed on patients whose physiological reserves are extraordinarily limited. This article examines the underlying pathophysiology, operative strategies, perioperative considerations, and long-term outcomes associated with the most critical surgical conditions encountered during the neonatal period. Conditions reviewed include congenital diaphragmatic hernia, esophageal atresia with tracheoesophageal fistula, abdominal wall defects, necrotizing enterocolitis, Hirschsprung disease, intestinal atresia’s, and anorectal malformations. The physiological vulnerabilities unique to neonates — among them transitional cardiovascular circulation, thermoregulatory instability, immature coagulation, and distinct pharmacokinetic profiles — are examined in the context of both anesthetic and surgical decision-making. Ethical dimensions, including fetal intervention and end-of-life care, are addressed throughout.
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[1] Canadian Congenital Diaphragmatic Hernia Collaborative. (2018). Diagnosis and management of congenital diaphragmatic hernia: A clinical practice guideline. Canadian Medical Association Journal, 190(4), E103–E112. https://doi.org/10.1503/cmaj.170206
[2] Yang, M. J., Russell, K. W., Yoder, B. A., & Fenton, S. J. (2021). Congenital diaphragmatic hernia: A narrative review of controversies in neonatal management. Translational Pediatrics, 10(5), 1432–1447. https://doi.org/10.21037/tp-20-142
[3] Hollinger, L. E., Harting, M. T., & Lally, K. P. (2017). Long-term follow-up of congenital diaphragmatic hernia. Seminars in Pediatric Surgery, 26(3), 178–184. https://doi.org/10.1053/j.sempedsurg.2017.04.007
[4] Zhu, Y., Wu, Y., Pu, Q., Ma, L., Liao, H., & Liu, L. (2016). Minimally invasive surgery for congenital diaphragmatic hernia: A meta-analysis. Hernia, 20(2), 297–302. https://doi.org/10.1007/s10029-015-1423-0
[5] Gasior, A. C., & St Peter, S. D. (2012). A review of patch options in the repair of congenital diaphragm defects. Pediatric Surgery International, 28(4), 327–333. https://doi.org/10.1007/s00383-012-3059-9
[6] Snoek, K. G., Reiss, I. K. M., Greenough, A., Capolupo, I., Urlesberger, B., Wessel, L., Storme, L., Deprest, J., Schaible, T., van Heijst, A., Tibboel, D., & CDH EURO Consortium. (2016). Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium consensus—2015 update. Neonatology, 110(1), 66–74. https://doi.org/10.1159/000444210
[7] O'Shea, D., Schmoke, N., Porigow, C., Murray, L. P., Chung, W. K., Kattan, M., Jang, M., Antosy, A., Middlesworth, W., & Khlevner, J. (2023). Recent advances in the genetic pathogenesis, diagnosis, and management of esophageal atresia and tracheoesophageal fistula: A review. Journal of Pediatric Gastroenterology and Nutrition, 77(6), 703–712. https://doi.org/10.1097/MPG.0000000000003952
[8] Kempker, T., & Peuterbaugh, J. (2025). Esophageal atresia and tracheoesophageal fistula: Diagnosis, management, and outcomes. NeoReviews, 26(5), e307–e315. https://doi.org/10.1542/neo.26-5-012
[9] Solomon, B. D. (2011). VACTERL/VATER association. Orphanet Journal of Rare Diseases, 6, 56. https://doi.org/10.1186/1750-1172-6-56
[10] Dingemann C, Dietrich J, Zeidler J, et al. (2016). Early complications after esophageal atresia repair. Diseases of the Esophagus, 29(7), 780–786. https://doi.org/10.1111/dote.12369
[11] Bielicki, I. N., Somme, S., Frongia, G., Holland-Cunz, S. G., & Vuille-dit-Bille, R. N. (2021). Abdominal wall defects—current treatments. Children, 8(2), 170. https://doi.org/10.3390/children8020170
[12] Bhat, V., Moront, M., & Bhandari, V. (2020). Gastroschisis: A state-of-the-art review. Children, 7(12), 302. https://doi.org/10.3390/children7120302
[13] Rentea, R. M., & Gupta, V. (2023). Gastroschisis. In StatPearls. StatPearls Publishing.
[14] Zahouani, T., & Mendez, M. D. (2023 ). Omphalocele. In StatPearls. StatPearls Publishing.
[15] Dekonenko, C., & Fraser, J. D. (2020). Approaches for closing gastroschisis. Advances in Pediatrics, 67, 123–129. https://doi.org/10.1016/j.yapd.2020.03.005
[16] Neu, J., & Walker, W. A. (2011). Necrotizing enterocolitis. New England Journal of Medicine, 364(3), 255–264. https://doi.org/10.1056/NEJMra1005408
[17] Hackam, D. J., Sodhi, C. P., & Good, M. (2019). New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment. Journal of Pediatric Surgery, 54(3), 398–404. https://doi.org/10.1016/j.jpedsurg.2018.06.012
[18] Christensen, R. D., Lambert, D. K., Baer, V. L., & Gordon, P. V. (2013). Necrotizing enterocolitis in term infants. Clinics in Perinatology, 40(1), 69–78. https://doi.org/10.1016/j.clp.2012.12.007
[19] Downard, C. D., Renaud, E., St. Peter, S. D., Abdullah, F., Islam, S., Saito, J. M., Blakely, M. L., & APSA Outcomes and Clinical Trials Committee. (2012). Treatment of necrotizing enterocolitis: An American Pediatric Surgical Association Outcomes and Clinical Trials Committee systematic review. Journal of Pediatric Surgery, 47(11), 2111–2122. https://doi.org/10.1016/j.jpedsurg.2012.08.011
[20] Blakely, M. L., Tyson, J. E., Lally, K. P., McDonald, S. A., Stoll, B. J., Stevenson, D. K., Poindexter, B. B., Bell, E. F., Sánchez, P. J., Van Meurs, K. P., Ball, M. B., Das, A., & Higgins, R. D. (2021). Initial laparotomy versus peritoneal drainage in extremely low birthweight infants with surgical necrotizing enterocolitis or isolated intestinal perforation. Annals of Surgery, 274(4), e370–e380. https://doi.org/10.1097/SLA.0000000000005099
[21] Caporilli, C., Giannì, G., Grassi, F., & Esposito, S. (2023). An overview of short-bowel syndrome in pediatric patients: Focus on clinical management and prevention of complications. Nutrients, 15(10), 2341 . https://doi.org/10.3390/nu15102341
[22] Karim, A., Tang, C. S. M., & Tam, P. K. H. (2021). The emerging genetic landscape of Hirschsprung disease and its potential clinical applications. Frontiers in Pediatrics, 9, 638093. https://doi.org/10.3389/fped.2021.638093
[23] Etskovitz, H., Kim, R. S., Wang, S. Z., & Nandivada, P. (2024). Surgical management of short-segment Hirschsprung disease. World Journal of Pediatric Surgery, 7(4), e000916. https://doi.org/10.1136/wjps-2024-000916
[24] Pakarinen, M. P., & Mutanen, A. (2024). Long-term outcomes and quality of life in patients with Hirschsprung disease. World Journal of Pediatric Surgery, 7(3), e000859. https://doi.org/10.1136/wjps-2024-000859
[25] Rich, B. S., Bornstein, E., & Dolgin, S. E. (2022). Intestinal atresias. Pediatrics in Review, 43(5), 266–274. https://doi.org/10.1542/pir.2021-005177
[26] Sigmon, D. F., Eovaldi, B. J., & Cohen, H. L. (2023). Duodenal atresia and stenosis. In StatPearls. StatPearls Publishing.
[27] Millar, A. J. W., Numanoglu, A., & Cox, S. (2017). Jejunoileal atresia and stenosis. In P. Puri (Ed.), Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_66-1
[28] Adams, S. D., & Stanton, M. P. (2014). Malrotation and intestinal atresias. Early Human Development, 90(12), 921–925. https://doi.org/10.1016/j.earlhumdev.2014.09.017
[29] van Praagh, J. B., Hofker, H. S., & Haveman, J.-W. (2022). Comparing bowel lengthening procedures: Which, when, and why? Current Opinion in Organ Transplantation, 27(2), 112–118. https://doi.org/10.1097/MOT.0000000000000957
[30] de Blaauw, I., Stenström, P., Yamataka, A., Miyake, Y., Reutter, H., Midrio, P., Wood, R., Grano, C., & Pakarinen, M. (2024). Anorectal malformations. Nature Reviews Disease Primers, 10, 88. https://doi.org/10.1038/s41572-024-00574-2
[31] Smith, C. A., & Avansino, J. (2023). Anorectal malformations. In StatPearls. StatPearls Publishing.
[32] Martin, L. D., Jimenez, N., & Lynn, A. M. (2017). A review of perioperative anesthesia and analgesia for infants: Updates and trends to watch. F1000Research, 6, 120. https://doi.org/10.12688/f1000research.10272.1
[33] Boyer, T. J., & Kritzmire, S. M. (2023). Neonatal anesthesia. In StatPearls. StatPearls Publishing.
[34] Hall, R. W., & Anand, K. J. S. (2014). Pain management in newborns. Clinics in Perinatology, 41(4), 895–924. https://doi.org/10.1016/j.clp.2014.08.010
[35] Campbell-Yeo, M., Eriksson, M., & Benoit, B. (2022). Assessment and management of pain in preterm infants: A practice update. Children, 9(2), 244. https://doi.org/10.3390/children9020244
[36] Walker, S. M. (2014). Neonatal pain. Paediatric Anaesthesia, 24(1), 39–48. https://doi.org/10.1111/pan.12293
[37] Morillo Palomo, A., Esquerda Aresté, M., Riverola de Veciana, A., & Cambra Lasaosa, F. J. (2024). End-of-life decision-making in the neonatal intensive care unit. Frontiers in Pediatrics, 11, 1352485. https://doi.org/10.3389/fped.2023.1352485
[38] Beauchamp, T. L., & Childress, J. F. (2019). Principles of biomedical ethics (8th ed.). Oxford University Press.
[39] Carter, B. S. (2018). Pediatric palliative care in infants and neonates. Children, 5(2), 21. https://doi.org/10.3390/children5020021
[40] Deprest, J. A., Nicolaides, K. H., Benachi, A., Gratacós, E., Ryan, G., Persico, N., Sago, H., Johnson, A., Wielgoś, M., Berg, C., Van Calster, B., Russo, F. M., & TOTAL Trial for Severe Hypoplasia Investigators. (2021). Randomized trial of fetal surgery for severe left diaphragmatic hernia. New England Journal of Medicine, 385(2), 107–118. https://doi.org/10.1056/NEJMoa2027030
[41] Adzick, N. S., Thom, E. A., Spong, C. Y., Brock, J. W., Burrows, P. K., Johnson, M. P., . . . Farmer, D. L. (2011). A randomized trial of prenatal versus postnatal repair of myelomeningocele. New England Journal of Medicine, 364(11), 993–1004. https://doi.org/10.1056/NEJMoa1014379.
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