Frequency of abnormal platelet indices among women presenting with preeclampsia

Authors

  • Khushboo
  • Asma
  • Tabassum Naz
  • Benish
  • Mehmoodah
  • Tooba Parveen

DOI:

https://doi.org/10.63682/jns.v14i32S.9982

Keywords:

Preeclampsia, Platelet count, Platelet volume, Platelet distribution width, Thrombocytopenia

Abstract

Objective: To determine the Frequency of abnormal platelet indices among women presenting with preeclampsia

Material and methods: This descriptive cross sectional study was conducted in duration of six months from 20-02-2017 to 19-08-2017, at Department of Obstetrics and Gynaecology Unit III, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana. In total 95 women of age 18-40 years, having pregnancy 20 to 40 weeks, alive singleton fetus and confirmed preeclampsia were included. Patients with history of chronic hypertension, Idiopathic Thromobocytopenic Purpura, using anticoagulant drugs within last one month, multiple gestation and morbid obesity were excluded. Mean + SD, frequencies & percentages were calculated. Chi-square was used as test of significance with a P value <0.05 as significant.

Results: Mean ± SD age of patients was 29.52 ± 6.17 years (Range 18 to 40). Mean ± SD parity was 1.71 ± 1.11 children (Range 1-4). Mean ± SD gestational age was 30.39 ± 4.90 weeks (Range 21-38). The mean platelet volume was 12.80 ± 6.82 fl, mean platelet count in mm3 was 2,22,997 ± 1,00,093 while mean platelet distribution width was 11.05 ± 5.95 fl. Thrombocytopenia was found positive among 32.6%. Frequency of abnormal platelet indices was 22.11% (n = 21).

Conclusion: Preeclampsia is very dangerous condition posing life threat to mother and the fetus. The current study found that platelet volume and platelet distribution width both increase while platelet count decreases among women who develop the preeclampsia..

Downloads

Download data is not yet available.

References

Askie LM, Duley L, Henderson-Smart D, Stewart LA. Antiplatelet agents for prevention of preeclampsia:a meta-analysis of individual patient data. Lancet. 2007;369:1791-8.

2. Leslie K, Thilaganathan B, Papageorghiou A. Early prediction and prevention of preeclampsia. Best Pract Res Clin Obstet Gynaecol. 2011;25:343-54.

3. Park Y, Schoene N, Haris W. Mean platelet volume as an indicator of platelet activation:methodological issues. Platelets. 2002;13:301-6.

4. The Perinatal antiplatelet review of international studies (PARIS) collaboration steering, group on behalf of the PARIS collaboration. Antiplatelet agents for prevention or preeclampsia and its consequences:a systematic review and individual patient data meta-analysis. BMC Preg Child-birth. 2005;5-7.

5. Hutt R, Ogunniyi SO, Sullivan MH, Elder MG. Increased platelet volume and aggregation precede the onset of preeclampsia. Obstet Gynecol. 1994 Jan;83(1):146-9.

6. Dundar O, Yoruk P, Tutuncu L, Erikci AA, Muhcu M, Ergur AR, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of preeclampsia. Prenat Diagn. 2008;28:1052-6.

7. Dadhich S, Agrawal S, Soni M, Choudhary R, Jain R, Sharma S. Predictive Value of Platelet Indices in Development of Preeclampsia. J South Asian Feder Obst Gynae. 2012;4(1):17-21.

8. Yang SW, Cho SH, Kwon HS, Sohn IS, Hwang HS. Significance of the platelet distribution width as a severity marker for the development of preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2014;175:107-11.

9. Yavuzcan A, Caglar M, Ustun Y, Dilbaz S, Ozdemir I, Yildiz E, et al. Mean platelet volume, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in severe preeclampsia. Ginekol Pol. 2014;85(3):197-203.

10. Kamel-Ammar WAE, El-Hei MAEH, Gehad MA, Mohamed MI. Evaluation of platelet indices and their significance in Preeclampsia. Nat Sci. 2014;12(3):147-53.

11. Han L, Liu X, Li H, Zou J, Yang Z. Blood Coagulation parameters and platelet indices:changes in normal and preeclamptic pregnancies and predictive values for preeclampsia. PLoS ONE. 2014;9(12):e114488.

12. Al-Sheeha MA, Alaboudi RS, Alghasham MA, Iqbal J, Adam I. Platelet count and platelet indices in women with preeclampsia. Vascular Health and Risk Management. 2016;12:477-80.

13. Yang SW, Cho SH, Kwon HS. Significance of the Platelet Distribution Width as a Severity Marker for the Development of Preeclampsia. European J Obstetrics & Gynecology and Reproductive Biology. 2014;175:107-11.

14. Dundar O, Yoruk P, Tutuncu L. Longitudinal Study of platelet size changes in gestation and predictive power of elevated MPV in development of preeclampsia. Prenatal Diagnosis. 2008;28:1052-56.

15. Järemo P, Lindahl TL, Lennmarken C. The Use of Platelet Density and Volume Measurements to Estimate the Severity of Preeclampsia. European J Clinical Investigation. 2000;30:1113-18.

16. Vagdatli E, Gounari E, Lazaridou E. Platelet distribution width:a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14:28-32.

17. Ceyhan T, Beyan C, Baser I. The Effect of Preeclampsia on Complete Blood Count, Platelet Count and Mean Platelet Volume. Annals of Hematology. 2006;85:320-2.

18. Makuyana D, Mahomed K, Shukusho FD. Liver and kidney function tests in normal and pre-eclamptic gestation:a comparison with non-gestational reference values. Central African J Medicine. 2002;48:55-9.

19. Vagdatli E, Gounari E, Lazaridou E. Platelet distribution width:a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14:28-32.

20. Kashanian M, Hajjaran M, Khatami E, Sheikhansari N. Evaluation of the value of the first and third trimester maternal mean platelet volume (MPV) for prediction of preeclampsia. Pregnancy Hypertens. 2013 Oct;3(4):222-6.

21. Akhila NR, Jayalakshmi L, Komala-Devi SD, Akhila NR. Study of mean platelet volume in gestational hypertension and normal pregnancy. International J Biomedical Research. 2015;6(06):366-9.

Downloads

Published

2025-11-07

How to Cite

1.
Khushboo K, Asma A, Naz T, Benish B, Mehmoodah M, Parveen T. Frequency of abnormal platelet indices among women presenting with preeclampsia. J Neonatal Surg [Internet]. 2025 Nov. 7 [cited 2026 Apr. 14];14(32S):10477-85. Available from: https://jneonatalsurg.com/index.php/jns/article/view/9982

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  • Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.