Cardioprotective Potential of Cucurbitaceae Seeds: A Systematic Review of Bioactive Profiles, Nutritional Synergy, and Therapeutic Implications for Heart Health

Authors

  • E.Sathya Priya
  • Saravanasingh Karan Chand Mohan Singh
  • L. Sridevi
  • Chandrasekar R.
  • T Susmitha
  • Kanniyakumari M
  • Renga Sundari
  • Senthamil Veni S
  • Nimeshika Devi S.V.L
  • Divya Jayachandran

Keywords:

Cucurbitaceae seeds, cardiovascular disease prevention, Omega-3 fatty acids Bioactive compounds, Phytosterols, Antioxidant stability

Abstract

This review synthesizes research on Cucurbitaceae seeds and heart health, focusing on specific types like pumpkin seeds, watermelon seeds, and cucumber seeds, to address gaps in understanding their nutritional and cardioprotective roles. The review aimed to evaluate the nutritional composition relevant to cardiovascular health, benchmark cardioprotective effects of omega-3 fatty acids and antioxidants, identify bioactive compounds, compare seed efficacy, and assess processing impacts. A systematic analysis of global studies employing biochemical profiling, clinical and animal models, and processing evaluations was conducted. Findings indicate that pumpkin seeds exhibit higher concentrations of omega-3 fatty acids, tocopherols, and phytosterols compared to watermelon and cucumber seeds, correlating with improved lipid profiles, reduced oxidative stress, and blood pressure modulation. Diverse bioactives including polyphenols, squalene, and cucurbitacins contribute synergistically to antioxidant and anti- inflammatory effects, though bioavailability data remain limited. Processing methods such as roasting and ultrasonication enhance nutrient retention and bioactive stability, yet standardized protocols are lacking. Comparative efficacy studies are scarce, particularly for watermelon and cucumber seeds, limiting comprehensive assessment. These findings collectively underscore the potential of Cucurbitaceae seeds as functional foods for cardiovascular disease prevention. Further rigorous clinical trials and standardized processing evaluations are necessary to optimize their therapeutic application and support nutraceutical development.

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Published

2025-03-10

How to Cite

1.
Priya E, Chand Mohan Singh SK, Sridevi L, Chandrasekar R. CR, T Susmitha TS, M K, et al. Cardioprotective Potential of Cucurbitaceae Seeds: A Systematic Review of Bioactive Profiles, Nutritional Synergy, and Therapeutic Implications for Heart Health. J Neonatal Surg [Internet]. 2025 Mar. 10 [cited 2026 Feb. 7];14(3):365-73. Available from: https://jneonatalsurg.com/index.php/jns/article/view/9915

Issue

Vol. 14 No. 3 (2025): Journal of Neonatal Surgery

Section

Original Article

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