Phytochemical Fingerprinting and Activity of Premna barbata Wall. ex-Schauer Stem Bark Extract
DOI:
https://doi.org/10.63682/jns.v13i1.9800Keywords:
Premna Barbata Wall, Ex Schauer, alpha-glucosidase, Phytochemical, HPTLC investigationAbstract
Premna Barbata Wall. Ex Schauer (family Verbenaceae) is found in the jungle provinces of the eastern and northern parts of India, Pakistan, Nepal, and Myanmar, in addition to in tropical and subtropical areas of Asia, Africa, Australia, and the Pacific Islands. It can be found in the lower Himalayas and the Shivalik tract in India. The range of raises is 800–1800 meters. Plant bark is 2 to 5 cm long and 1 to 2 cm wide, with a little quilled shape. The superficial surface is grey, while the inner surface is white. The analysis of the literature divulges that the plant has been the subject of very few actual investigations and studies. The present study is based on an initial phytochemical screening examination and an assessment of the in vitro potential for the inhibition of the enzyme’s alpha-glucosidase and alpha-amylase. The research indicates that the hydro-alcoholic extract comprises a range of phytochemical constituents present in diverse quantities, such as loss on drying (11.4%), total starch (0.92%), total sugar (0.66%), flavonoids (0.24%), tannins (1.24%), phenolic compounds (3.10%), proanthocyanidins (2.18%), and flavonols (0.23%), among others
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1. Joshi, B. C., Juyal, V., Sah, A. N., & Mukhija, M. (2022). Ethnopharmacology, botanical description and phytochemistry of premna barbata: an unexplored medicinal plant species from lamiaceae family. Current Traditional Medicine, 8(6), 60-66.
2. Munir, A. A. (1984). A taxonomic revision of the genus Premna L.(Verbenaceae) in Australia. Journal of the Adelaide Botanic Garden, 1-43.
3. Dianita, R., & Jantan, I. (2017). Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna: a review. Pharmaceutical biology, 55(1), 1715-1739.
4. Joshi, B. C., Juyal, V., Sah, A. N., & Mukhija, M. (2023). In-Vitro Antiproliferative Efficacy, Antioxidant bioactivity and LC-MS Based Metabolite Profiling of Premna barbata Stem Bark.
5. Singh, C., Mehata, A. K., Muthu, M. S., & Tiwari, K. N. (2024). Premna integrifolia: A Review on the Exploration of its Potential Pharmacological and Therapeutic Properties. Current Traditional Medicine, 10(2), 37-50.
6. Yadav, D., Masood, N., Luqman, S., Brindha, P., & Gupta, M. M. (2013). Antioxidant furofuran lignans from Premna integrifolia. Industrial Crops and Products, 41, 397-402.
7. Singh, C., Mehata, A. K., Muthu, M. S., & Tiwari, K. N. (2024). Premna integrifolia: A Review on the Exploration of its Potential Pharmacological and Therapeutic Properties. Current Traditional Medicine, 10(2), 37-50.
8. Roza Dianita, R. D., & Ibrahim Jantan, I. J. (2017). Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna: a review.
9. Sudo, H., Takushi, A., Hirata, E., Ide, T., Otsuka, H., & Takeda, Y. (1999). Premnaodorosides D–G: acyclic monoterpenediols iridoid glucoside diesters from leaves of Premna subscandens. Phytochemistry, 52(8), 1495-1499.
10. L. X. Guo, J. H. Liu, and F. Yin,“Regulation of insulin secretion by geniposide: possible involvement of phosphatidylinositol 3- phosphate kinase,” European Review for Medical and Pharmacological Sciences, vol. 18, no. 9, pp. 1287–1294, 2014.
11. J. Yan, C. Wang, Y. Jin et al., “Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway,” Pharmacological study, vol. 130, pp. 466–480, 2018.
12. P. Jiang, L. Xiang, Z. Chen et al., “Catalpol alleviates renal damage by improving lipid metabolism in diabetic db/db mice,” American Journal of Translational study, vol. 10 no. 6, pp. 1750–1761, 2018.
13. J. Liu, H. R. Zhang, Y. B. Hou, X. L. Jing, X. Y. Song, and X. P. Shen, “Global gene expression analysis in liver of db/db mice treated with catalpol,” Chinese Journal of Natural Medicines, vol. 16, no. 8, pp. 590–598, 2018.
14. C. Liu, Y. Hao, F. Yin, Y. Zhang, and J. Liu, “Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase,” Cell Biology International, vol. 41, no. 5, pp. 544–554, 2017.
15. Williamson E., Okpako D.T., Evans F.J., 1996. Selection, Preparation and Pharmacological Evaluation of Plant Material, Wiley, Chichester.
16. Goldfrank L., 1982. The Pernicious Panacea: Herbal Medicine. Hospital Physician, Vol. 10, pp. 64–86.
17. Malik C.P., Singh M.B., 1980. PlantEnzymology and Histoenzymology, Kalyani Publishers, New Delhi, pp. 278.
18. Soldati F., 1997. The registration of medicinal plant products, what quality of documentation should be required. The industrial point of view In: World Congress on Medicinal and Aromatic Plants for Human Welfare, Vol. 2, pp. L-48.
19. Vulto A.G., Smet P.A., 1988. In: Dukes, M.M.G. (Ed.). Meyler’s Side Effects of Drugs, Elsevier, Amsterdam, 11th Ed. pp. 999–1005.
20. Gruenwald J., 1997. The market situation and marketing of herbal medicinal products (HMP) in Europe. In: World Congress on Medicinal And Aromatic Plants For Human Welfare, Vol. 2, pp. L-33.
21. Brevoort P., 1997. The current status of the US botanical market in: World Congress on Medicinal and Aromatic Plants For Human Welfare, Vol. 2, p. L-42.
22. Israelsen L.D., 1997. United States regulatory status of botanical preparations in:World Congress on Medicinal And AromaticPlants for Human Welfare, 2, pp. L-44.
23. Brevoort P., 1997. The current status of the US botanical market in World Congress on Medicinal and Aromatic Plants for Human Welfare, Vol. 2, pp. L-42.
24. Elisabetsky E., 1987. Pesquisas em Plantas medicinais. Cieˆncia e Cultura, Vol. 39 (8), pp. 697–702.
25. Rouhi A.M., 1997. Seeking drugs in natural products. Vol. 7, pp. 14–29.
26. Reid W.V., Laird S.A., Meyer C.A., Ga´mez R., Sittenfeld A., Janzen D.H., Gollin M.A., Juma C., 1993. Biodiversity Prospecting: Using Genetic Resources for Sustainable Development. World Resources Institute (USA).
27. Payne G., Bringi V., Prince C., Shuller M., 1991. The quest for commercial production of chemicals from plant cell culture, Plant Cell and Tissue Culture in Liquid Systems, Oxford University Press, Oxford.
28. Hamburger M., Hostettmann K., 1991. Bioactivity in plants: the link between phytochemistry and medicine. Phytochemistry,Vol. 30 (12), pp. 3864–3874.
29. Borris R.P., 1996. Natural products study: perspectives from a major pharmaceutical company. Journal of Ethnopharmacology, Vol. 51 (1/3), pp. 29–38.
30. Williamson E., Okpako D.T., Evans F.J., 1996. Selection, Preparation and Pharmacological Evaluation of Plant Material, Wiley, Chichester..
.
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