Prevalence Of Glaucoma Suspects Based On Iop And Optic Disc Findings Risk Factors, Early Detection.

Authors

  • Muhammad Waseem
  • Muhammad Rafiq
  • Jehanzeb Khan
  • Muhammad Zeeshan Tahir
  • Syed Amir Hamza
  • Maria Sultan

Keywords:

Glaucoma suspects, Intraocular pressure, Optic disc changes, Early detection

Abstract

Background: Elevated Intraocular Pressure (IOP), such as that in a glaucoma suspect, is one of the minor diagnostic criteria of the Ocular Hypertension Treatment Study (OHTS), as well as the findings of the optic disc, which points to the suspected optic disc as the overlying optic nerve head presenting signs of a head that may be blurred at the edges. OHTS suspects were also studied in the predictive value of disc and visual field abnormalities. The role of the optometrist in the minor predictive value of the disc.

Objectives: To determine the prevalence of glaucoma suspects based on intraocular pressure (IOP) measurements and optic disc characteristics, and to evaluate their association with early clinical detection, demographic and systemic risk factors, and ocular findings.

Methodology: This Cross Sectional Study conducted at department of Ophthalmology, Gajju Khan Medical College Swabi from jan 2023 to jan 2024.Demographic information, systemic history, and refractive data were collected in a cross-sectional study of adult patients visiting an eye clinic, with informed consent obtained. Goldmann applanation tonometry was used to measure IOP, and fundus exams were dilated to evaluate CDR asymmetry, rim thinning, and disc haemorrhages. Those who had IOP higher than 21 mmHg or had morphologies of the optic disc that were deemed suspicious were placed in the category of glaucoma suspect.

Results:  A total of 100 patients were examined, with a mean age of 47.2 ± 12.5 years; 55% were male. Myopia was present in 32%, diabetes in 22%, and hypertension in 28%. The prevalence of glaucoma suspects was 19% (n = 19). Mean IOP was significantly higher in suspects (23.6 ± 3.5 mmHg) than no suspects (16.2 ± 2.7 mmHg, p < 0.001). Mean CDR was also greater (0.67 ± 0.08 vs. 0.42 ± 0.10, p < 0.001). Older age (p = 0.02), myopia (p = 0.04), and family history (p = 0.03) were significantly associated.

Conclusion: This outpatient population had a relatively commonality of glaucoma suspects in which specific positive correlations were exhibited regarding age, myopia and family history. High IOP levels and questionable optic disc findings remained strong predictors of risk. Prompt identification of suspects enables timely monitoring, modification of risk factors, and initiation of appropriate therapy..

 

Downloads

Download data is not yet available.

References

Ahmad SS. Glaucoma suspects: A practical approach. Taiwan journal of ophthalmology. 2018;8(2):74-81.

2. Berkenstock MK, Parikh RA, Collins MD, Ricard DA, Rozar SR, Castoro CJ, et al. Use of Contact Lenses to Optimize OCT Scans of the Optic Nerve in Glaucoma Suspects or Patients with Glaucoma with High Myopia. Ophthalmology Glaucoma. 2020;3(3):196-201.

3. Chaurasia S, Garg R, Beri S, Pakhare A. Sonographic Assessment of Optic Disc Cupping and its Diagnostic Performance in Glaucoma. Journal of glaucoma. 2019;28(2):131-8.

4. Hoffman BB, Rosenfeld E, Grajewski AL, Chang TC. Glaucomatous optic disc changes despite normal baseline intraocular pressure in a child. American journal of ophthalmology case reports. 2019;13:104-9.

5. Kang JM, Jammal AA, Medeiros FA. Association between statin use and rates of structural and functional loss in glaucoma. The British journal of ophthalmology. 2023;107(9):1269-74.

6. Kletke SN, Mills MD, Tomlinson LA, Yu Y, Ying GS, Binenbaum G. Pediatric glaucoma suspects: characteristics and outcomes. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 2022;26(5):236.e1-.e6.

7. Lin F, Chen S, Song Y, Li F, Wang W, Zhao Z, et al. Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change. Ophthalmology. 2022;129(7):803-12.

8. Miller GD, Abu-Qamar O, Salim S. Evaluation of Retinal Nerve Fiber Layer, Ganglion Cell-Inner Plexiform Layer, and Optic Nerve Head in Glaucoma Suspects With Varying Myopia. Journal of glaucoma. 2021;30(5):e213-e21.

9. Wang X, Chen J, Kong X, Sun X. Immediate Changes in Peripapillary Retinal Vasculature after Intraocular Pressure Elevation -an Optical Coherence Tomography Angiography Study. Current eye research. 2020;45(6):749-56.

10. Wang YX, Zhang Q, Yang H, Chen JD, Wang N, Jonas JB. Lamina cribrosa pore movement during acute intraocular pressure rise. The British journal of ophthalmology. 2020;104(6):800-6.

11. Gardiner SK, Cull G, Fortune B, Wang L. Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma. Investigative ophthalmology & visual science. 2019;60(8):3110-8.

12. Hood DC, Melchior B, Tsamis E, Liebmann JM, De Moraes CG. Did the OCT Show Progression Since the Last Visit? Journal of glaucoma. 2021;30(4):e134-e45.

13. Hsia Y, Su CC, Wang TH, Yang CM, Huang JY. Long-term follow-up of retinal nerve fiber layer cleavages in glaucoma patients and suspects. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2018;256(10):1945-52.

14. Marshall H, Berry EC, Torres SD, Mullany S, Schmidt J, Thomson D, et al. Association Between Body Mass Index and Primary Open Angle Glaucoma in Three Cohorts. American journal of ophthalmology. 2023;245:126-33.

15. Medeiros FA, Jammal AA, Mariottoni EB. Detection of Progressive Glaucomatous Optic Nerve Damage on Fundus Photographs with Deep Learning. Ophthalmology. 2021;128(3):383-92.

16. Nelson AJ, Chu Z, Burkemper B, Chang BR, Xu B, Wang RK, et al. Clinical Utility of Triplicate En Face Image Averaging for Optical Coherence Tomography Angiography in Glaucoma and Glaucoma Suspects. Journal of glaucoma. 2020;29(9):823-30.

17. Resch H, Schwarzhans F, Frommlet F, Hommer A, Fuchs P, Vass C. Optical coherence tomography-measured retinal nerve fiber layer thickness values compensated with a multivariate model and discrimination between stable and progressing glaucoma suspects. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2022;260(1):225-33.

18. Saks D, Schulz A, Sheriff S, Shen T, Gupta V, Qassim A, et al. Quantification of localised vascular wedge-shaped defects in glaucoma. Clinical & experimental ophthalmology. 2022;50(7):724-35.

19. Seth NG, Kaushik S, Kaur S, Raj S, Pandav SS. 5-year disease progression of patients across the glaucoma spectrum assessed by structural and functional tools. The British journal of ophthalmology. 2018;102(6):802-7.

20. Stagg BC, Medeiros FA. A Comparison of OCT Parameters in Identifying Glaucoma Damage in Eyes Suspected of Having Glaucoma. Ophthalmology Glaucoma. 2020;3(2):90-6.

Downloads

Published

2025-11-02

How to Cite

1.
Waseem M, Rafiq M, Khan J, Zeeshan Tahir M, Hamza SA, Sultan M. Prevalence Of Glaucoma Suspects Based On Iop And Optic Disc Findings Risk Factors, Early Detection. J Neonatal Surg [Internet]. 2025 Nov. 2 [cited 2026 Apr. 14];14(32S):10046-51. Available from: https://jneonatalsurg.com/index.php/jns/article/view/9744