Antioxidant And Anti-Inflammatory Properties Of The Marine Crab Tumidodromia Dormiahemolymph Lectin
Keywords:
Marine crab lectin, ABTS, COX, LOX, DPPH, FRAP, LPICAbstract
The marine environment is a farm of unique bioactive components that display great potential as therapeutic agents. The study on antioxidant and anti-inflammatory activities comprehensively examines the properties of purified lectin isolated from the marine crab Tumidodromia dormia. The lectin exhibits ABTS radical scavenging with an IC50 value of 19.56 µg/ml, outperforming ascorbic acid and inhibiting lipid peroxidation more effectively than Trolox, with moderate activity in DPPH and FRAP assays. The presence of anti-inflammatory properties was confirmed through cyclooxygenase (COX) and lipoxygenase (LOX) inhibition, with each having an IC50 value of 59.5 µg/ml and 61.7 µg/ml, respectively. These results elucidate the multifunctional potential of the marine crab lectins as a template for novel drug development for oxidative and inflammatory diseases..
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