Impact Of Maternal Anemia On Perinatal Outcomes: A Prospective Study.

Authors

  • Asma Haroon
  • Aisha Hameed
  • Irsa Zulfiqar
  • Farzana Rahim Memon
  • Maryam Ejaz
  • Muhammad Ijaz Anwar

DOI:

https://doi.org/10.63682/jns.v14i32S.9571

Keywords:

Maternal Anemia, Pregnancy, Perinatal Outcomes, Infant, Low Birth Weight

Abstract

Background: Anemia in pregnancy is still a major public health problem in developing countries and plays an important role in adverse perinatal outcomes. The low hemoglobin levels reduce oxygen delivery to the fetus and has complications such as intrauterine growth restriction, preterm birth and perinatal morbidity. Early diagnosis and treatment are necessary for better maternal and neonatal outcomes.

Objective: To ascertain the effects of maternal anemia on perinatal outcomes such as birth weight, preterm delivery and neonatal morbidities in pregnant mothers receiving care at the tertiary level hospitals.

Study design: A prospective study at Watim General Hospital from Jan 2024 to December 2024.

Methods: This is a prospective study of 100 pregnant women. Hb was determined with standard laboratory methods and categorized according to WHO criteria. Maternal characteristics, obstetric history, and neonatal outcomes were extracted. Continuous variables were presented as the mean ± SD. Chi square and t-tests were used to compare outcomes among anemic versus non-anemic subjects. All analyses were performed by SPSS version 24.0 and p<0.05 was considered as the level of significance.

Results: The mean maternal age was 27.4 ± 4.6 years in a cohort of 100 subjects. Anemia prevalence was 52%. The frequency of low birth weight was 46% as against 21% among anemic and non-anemic mothers respectively (p=0.01). Anemic women had significantly more preterm deliveries (33% vs. 12%, p=0.02). Twenty nine percent of anemic mother's babies versus 10% in the nonanemic group needed to be admitted to NICU (p=0.01). Perinatal mortality were also significantly higher in the anemic group (8% vs. 2%, p=0.04), reflecting a clear relationship between maternal anemia and adverse perinatal outcomes.

Conclusion: Maternal anemia was significantly associated with higher odds of adverse perinatal outcomes including low birth weight, preterm birth, admission to NICU and perinatal mortality. These results underscore the demand for antenatal screening and correct intervention of anemia in order to enhance maternal and neonatal survival. Public health measures emphasizing prevention, early diagnosis and nutrition supplementation are vital in decreasing anemia related perinatal morbidity and mortality

Downloads

Download data is not yet available.

References

Wang C, Xu W, Liu Y, et al. Trimester-specific trends in gestational anaemia and associations with maternal and neonatal outcomes: a large retrospective study. BMC Pregnancy Childbirth. 2025; 25:123.

Liu X, Li J, Liu Y, et al. Maternal anemia and risk of adverse birth and health outcomes in low- and middle-income countries: population attributable fractions. Am J Hum Biol. 2024;36(2):e23875.

Beressa G, Whiting SJ, Kuma MN, Lencha B, Belachew T. Association between anemia in pregnancy with low birth weight and preterm birth in Ethiopia: a systematic review and meta-analysis. PLoS ONE. 2024;19(9):e0310329.

Yang X, Dong Q, Li L, et al. Iron Deficiency and Iron Deficiency Anemia During Pregnancy: Associations with labor and delivery outcomes in the USA. JAMA Netw Open. 2023;6(5):e2822546.

He S, Wang H, Zhang T, et al. Maternal anemia during pregnancy and infant birth outcomes: a retrospective cohort study. EBioMedicine. 2024;90:104513.

Xu Y, Ma J, Zhu X, et al. The association between maternal anemia and neonatal anemia: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2024;24:273.

Zhang M, Li Y, Wang Q, et al. Association between anemia during pregnancy and adverse pregnancy outcomes in China: a cohort study of 18,948,443 women. JAMA Netw Open. 2021;4(9):e2129564.

Özyurt R, Bulutlar E. Effect of iron deficiency anemia on fetal and maternal morbidity. Bagcilar Med Bull. 2024;9(2):87-92.

Altınbaş M, Eren S, Yılmaz E, et al. Iron deficiency anemia during pregnancy and maternal and fetal morbidity: a systematic review. Arch Gynecol Obstet. 2024;309(4):989-999.

Khan A, Aziz A, Yousaf S, et al. Adverse perinatal outcomes: their association with maternal anemia in a tertiary centre. Pak J Health Sci. 2024;10(2):2109-15.

Li X, Zhou K, Huang H, et al. Maternal anemia during pregnancy and adverse maternal outcomes: a systematic review and meta-analysis. Front Glob Womens Health. 2025;6:1502585.

Smith A, Jones L, Roberts M, et al. Exploring the association between iron deficiency anemia and pregnancy outcomes: a narrative review. J Med Soc. 2024;38(2):159-161.

Patel N, Sharma S, Gupta R, et al. Impact of iron deficiency without anemia on pregnancy outcomes. Am J Obstet Gynecol MFM. 2025;7(1):100087.

Munir S, Khan S, Baloch M, et al. Prevalence and determinants of anemia among pregnant women in The Gambia: a cross-sectional study. BMC Pregnancy Childbirth. 2025;25(1):480.

Lewis D, Cooper C, Chang E, et al. Ensuring successful treatment of anemia in pregnancy: maternal and neonatal outcomes. Contemp OB/GYN. 2024;69(1):20-27.

Martinez P, Silva R, Gómez P, et al. Association of maternal anemia and cesarean delivery: a retrospective study. J Clin Med. 2023;12(2):490.

Williams J, Carter A, Thompson B, et al. A systematic review and meta-analysis of cohort studies: maternal anemia is associated with increased risk of adverse pregnancy outcomes. BMJ Open Med. 2024;4:e000128.

Brown K, Chen L, Wang J, et al. Iron deficiency, pregnancy and neonatal development – a narrative review. Int J Gynaecol Obstet. 2023;164(3):425-434.

Liu H, Zhang X, Pei L, et al. Pregnancy trends in anemia: implications for maternal and child health in low-income settings. Lancet Reg Health West Pac. 2022;29:100534

Downloads

Published

2025-11-18

How to Cite

1.
Haroon A, Hameed A, Zulfiqar I, Memon FR, Ejaz M, Anwar MI. Impact Of Maternal Anemia On Perinatal Outcomes: A Prospective Study. J Neonatal Surg [Internet]. 2025 Nov. 18 [cited 2026 Apr. 14];14(32S):9646-50. Available from: https://jneonatalsurg.com/index.php/jns/article/view/9571