Pharmacological Evaluation of the Wound Healing Potential of Rubus paniculatus in Preclinical Models

Authors

  • Vishal Shukla
  • Waseem Khan
  • Sanjay Singh

Keywords:

Rubus paniculatus, wound healing, burn model, phytotherapy, silver sulfadiazine, topical formulation, preclinical pharmacology

Abstract

Rubus paniculatus, a wild Himalayan raspberry traditionally used in Indian ethnomedicine, was evaluated for its wound healing efficacy using preclinical burn models. Hydroalcoholic extracts of the plant were formulated into topical creams (1% and 2.5%) and tested against silver sulfadiazine (1%) in Wistar rats with thermally induced partial-thickness burns. Phytochemical screening confirmed the presence of flavonoids, tannins, phenolics, saponins, and glycosides—compounds known for their antioxidant and anti-inflammatory properties. Over a 21-day treatment period, the 2.5% extract formulation significantly accelerated wound contraction, epithelialization, and skin restoration compared to controls and standard treatment (p < 0.0001). Histological and physical observations supported enhanced tissue regeneration and cosmetic recovery. These findings validate the traditional use of R. paniculatus in wound care and highlight its potential as a plant-based therapeutic for burn management

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References

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Published

2025-08-18

How to Cite

1.
Shukla V, Khan W, Singh S. Pharmacological Evaluation of the Wound Healing Potential of Rubus paniculatus in Preclinical Models. J Neonatal Surg [Internet]. 2025Aug.18 [cited 2025Dec.6];14(32S):9475-84. Available from: https://jneonatalsurg.com/index.php/jns/article/view/9523

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

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