Management of Acute Abdomen: Evidence-Based Approaches, Diagnostic Challenges, and Surgical Innovations
Keywords:
Acute abdomen, diagnostics, laparoscopy, ERAS protocols, surgical innovationsAbstract
Acute abdomen is an acute and severe pain in the abdomen that is a sign of underlying intra-abdominal pathology that may necessitate urgent or emergent action. It is characterised by a wide range of causes of obstructive, inflammatory, vascular and perforative etiologies, which demand different diagnoses and treatment efforts. Nonspecific symptoms augment the difficulty of timely diagnosis, particularly in elderly, immunocompromised and pregnant patients. Even though diagnostic instruments such as computed tomography (CT) and magnetic resonance imaging (MRI) have improved the precision of diagnosis, resource constraints in low- and middle-income countries (LMICs) continue to increase the delays and poorer outcomes. Diagnostic imaging overuse has led to an increase in healthcare expenditure and unnecessary radiation exposure in high-income countries. The development of surgical procedures, especially minimally invasive surgery such as laparoscopy and robotic surgery, has minimised recovery time and pain after surgery. Moreover, there are also Enhanced Recovery After Surgery (ERAS) protocols that have played a significant role in the improvement of the postoperative outcomes through the encouragement of early mobility, pain management and nutrition. This is a review of evidence-based practices in the diagnosis and treatment of acute abdomen, and it discusses the issues in diagnosis, management paradigms, and the importance of surgical innovations. There is a focus on the incorporation of new technologies and optimization of clinical pathways to enhance patient outcomes in the world.
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Alowais, S. A., Alghamdi, S. S., Alsuhebany, N., Alqahtani, T., Alshaya, A. I., Almohareb, S. N., Aldairem, A., Alrashed, M., Bin Saleh, K., Badreldin, H. A., Al Yami, M. S., Al Harbi, S., & Albekairy, A. M. (2023). Revolutionizing healthcare: the role of artificial intelligence in clinical practice. BMC medical education, 23(1), 689. https://doi.org/10.1186/s12909-023-04698-z
Amin, T., Mobbs, R. J., Mostafa, N., Sy, L. W., & Choy, W. J. (2021). Wearable devices for patient monitoring in the early postoperative period: a literature review. mHealth, 7, 50. https://doi.org/10.21037/mhealth-20-131
Bala, M., Catena, F., Kashuk, J., De Simone, B., Gomes, C. A., Weber, D., Sartelli, M., Coccolini, F., Kluger, Y., Abu-Zidan, F. M., Picetti, E., Ansaloni, L., Augustin, G., Biffl, W. L., Ceresoli, M., Chiara, O., Chiarugi, M., Coimbra, R., Cui, Y., Damaskos, D., … Moore, E. E. (2022). Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery. World journal of emergency surgery : WJES, 17(1), 54. https://doi.org/10.1186/s13017-022-00443-x
Bassetti, M., Eckmann, C., Giacobbe, D. R., Sartelli, M., & Montravers, P. (2020). Post-operative abdominal infections: epidemiology, operational definitions, and outcomes. Intensive care medicine, 46(2), 163–172. https://doi.org/10.1007/s00134-019-05841-5
Bignami, E. G., Panizzi, M., Bezzi, F., Mion, M., Bagnoli, M., & Bellini, V. (2025). Wearable devices as part of postoperative early warning score systems: a scoping review. Journal of clinical monitoring and computing, 39(1), 233–244. https://doi.org/10.1007/s10877-024-01224-4
Börner, N., Kappenberger, A. S., Weber, S., Scholz, F., Kazmierczak, P., & Werner, J. (2025). The Acute Abdomen: Structured Diagnosis and Treatment. Deutsches Arzteblatt international, 122(5), 137–144. https://doi.org/10.3238/arztebl.m2025.0019
Brusasco, C., Cucciolini, G., Barberis, A., Introini, C., Campodonico, F., & Corradi, F. (2024). Improving Patient Outcomes in Abdominal Surgery. Journal of clinical medicine, 13(7), 1993. https://doi.org/10.3390/jcm13071993
Cervellin, G., Mora, R., Ticinesi, A., Meschi, T., Comelli, I., Catena, F., & Lippi, G. (2016). Epidemiology and outcomes of acute abdominal pain in a large urban Emergency Department: retrospective analysis of 5,340 cases. Annals of translational medicine, 4(19), 362. https://doi.org/10.21037/atm.2016.09.10
Chen, X., Zhu, W., Tan, J., Nie, H., Liu, L., Yan, D., Zhou, X., & Sun, X. (2017). Early outcome of early-goal directed therapy for patients with sepsis or septic shock: a systematic review and meta-analysis of randomized controlled trials. Oncotarget, 8(16), 27510–27519. https://doi.org/10.18632/oncotarget.15550
Cliff, B. Q., Avanceña, A. L. V., Hirth, R. A., & Lee, S. D. (2021). The Impact of Choosing Wisely Interventions on Low-Value Medical Services: A Systematic Review. The Milbank quarterly, 99(4), 1024–1058. https://doi.org/10.1111/1468-0009.12531
Cornejo, J., Cornejo-Aguilar, J. A., Vargas, M., Helguero, C. G., Milanezi de Andrade, R., Torres-Montoya, S., Asensio-Salazar, J., Rivero Calle, A., Martínez Santos, J., Damon, A., Quiñones-Hinojosa, A., Quintero-Consuegra, M. D., Umaña, J. P., Gallo-Bernal, S., Briceño, M., Tripodi, P., Sebastian, R., Perales-Villarroel, P., De la Cruz-Ku, G., Mckenzie, T., … Russomano, T. (2022). Anatomical Engineering and 3D Printing for Surgery and Medical Devices: International Review and Future Exponential Innovations. BioMed research international, 2022, 6797745. https://doi.org/10.1155/2022/6797745
de Jonge, J., Scheijmans, J. C. G., van Rossem, C. C., van Geloven, A. A. W., Boermeester, M. A., Bemelman, W. A., & Snapshot Appendicitis Collaborative Study group (2021). Normal inflammatory markers and acute appendicitis: a national multicentre prospective cohort analysis. International journal of colorectal disease, 36(7), 1507–1513. https://doi.org/10.1007/s00384-021-03933-7
de Oliveira Varca, L., & de Almeida Santos, M. C. (2024). Current Topics in Acute Abdomen: Causes, Diagnostics, and Emerging Therapies. Journal of Biosciences and Medicines, 12(5), 171-177.
Dyas, A. R., Zhuang, Y., Meguid, R. A., Henderson, W. G., Madsen, H. J., Bronsert, M. R., & Colborn, K. L. (2022). Development and validation of a model for surveillance of postoperative bleeding complications using structured electronic health records data. Surgery, 172(6), 1728–1732. https://doi.org/10.1016/j.surg.2022.08.021
Hartley, J. (2012, July 22). The management of anastomotic leak [PowerPoint presentation]. Academic Surgical Unit, University of Hull. SlideServe. https://www.slideserve.com/petunia/the-management-of-anastomotic-leak
Hedrick, T. L., & Kane, W. (2021). Management of Acute Anastomotic Leaks. Clinics in colon and rectal surgery, 34(6), 400–405. https://doi.org/10.1055/s-0041-1735271
Jackson, M., & Cairns, T. (2021). Care of the critically ill patient. Surgery (Oxford, Oxfordshire), 39(1), 29–36. https://doi.org/10.1016/j.mpsur.2020.11.002
Katikam, S. M., Komari, L. K., & Parimi, S. B. R. (2025). Evaluation of Enhanced Recovery After Surgery (ERAS) Protocols in Abdominal Surgery. Journal of pharmacy & bioallied sciences, 17(Suppl 2), S1805–S1807. https://doi.org/10.4103/jpbs.jpbs_1900_24
Kumar, R., Marla, K., Sporn, K., Paladugu, P., Khanna, A., Gowda, C., Ngo, A., Waisberg, E., Jagadeesan, R., & Tavakkoli, A. (2025). Emerging diagnostic approaches for musculoskeletal disorders: advances in imaging, biomarkers, and clinical assessment. Diagnostics, 15(13), 1648. https://doi.org/10.3390/diagnostics15131648
Lakananurak, N., & Gramlich, L. (2020). Nutrition management in acute pancreatitis: Clinical practice consideration. World journal of clinical cases, 8(9), 1561–1573. https://doi.org/10.12998/wjcc.v8.i9.1561
Lin, P., Chen, T., Lin, C., Huang, C., Tsai, Y., Tsai, Y., & Wang, C. (2024). The use of augmented reality (AR) and virtual reality (VR) in dental surgery education and practice: A narrative review. Journal of Dental Sciences, 19, S91-S101. https://doi.org/10.1016/j.jds.2024.10.011
Liu, Y., Samaan, J. S., Essanaa, Y. M., Lv, F., Ji, F., Samakar, K., & Yeo, Y. H. (2024). Trends in the mortality of intra-abdominal infections in adults over 25 years in the USA, 1999–2021. Emergency Medicine Journal, 41(5), 324-326.
Mannam, R., Sankara Narayanan, R., Bansal, A., Yanamaladoddi, V. R., Sarvepalli, S. S., Vemula, S. L., & Aramadaka, S. (2023). Laparoscopic Cholecystectomy Versus Open Cholecystectomy in Acute Cholecystitis: A Literature Review. Cureus, 15(9), e45704. https://doi.org/10.7759/cureus.45704
Martin, G. S., & Bassett, P. (2019). Crystalloids vs. colloids for fluid resuscitation in the Intensive Care Unit: A systematic review and meta-analysis. Journal of critical care, 50, 144–154. https://doi.org/10.1016/j.jcrc.2018.11.031
Meena, J., Patel, R., & Datey, A. (2025). Study of etiological factors, clinical profile and outcomes of the non-traumatic acute abdomen in adult patients. International Surgery Journal, 12(4), 547–554. https://doi.org/10.18203/2349-2902.isj20250813
Mervak, B. M., Fried, J. G., & Wasnik, A. P. (2023). A Review of the Clinical Applications of Artificial Intelligence in Abdominal Imaging. Diagnostics (Basel, Switzerland), 13(18), 2889. https://doi.org/10.3390/diagnostics13182889
Mirzamohamadi, S., HajiAbbasi, M. N., Baigi, V., Salamati, P., Rahimi-Movaghar, V., Zafarghandi, M., Isfahani, M. N., Fakharian, E., Saeed-Banadaky, S. H., Hemmat, M., Sadrabad, A. Z., Daliri, S., Pourmasjedi, S., Piri, S. M., Naghdi, K., & Yazdi, S. A. M. (2024). Patterns and outcomes of patients with abdominal injury: a multicenter study from Iran. BMC emergency medicine, 24(1), 91. https://doi.org/10.1186/s12873-024-01002-0
Noori, I. F., Jabbar, A. S., & Noori, A. F. (2023). Clinical scores (Alvarado and AIR scores) versus imaging (ultrasound and CT scan) in the diagnosis of equivocal cases of acute appendicitis: a randomized controlled study. Annals of medicine and surgery (2012), 85(4), 676–683. https://doi.org/10.1097/MS9.0000000000000270
Orije, J. (2023). Medical imaging modalities [BioRender template]. BioRender. https://www.biorender.com/template/medical-imaging-modalities
Osmosis. (2025, October 25). Postoperative care: Nursing [Video]. Osmosis. https://www.osmosis.org/video/Postoperative_care%3A_Nursing
Phelan, H., Yates, V., & Lillie, E. (2022). Challenges in healthcare delivery in low- and middle-income countries. Anaesthesia and Intensive Care Medicine, 23(8), 501–504. https://doi.org/10.1016/j.mpaic.2022.05.004
Qaiser, S., Noman, M., Khan, M. S., Ahmed, U. W., & Arif, A. (2024). The Role of WHO Surgical Checklists in Reducing Postoperative Adverse Outcomes: A Systematic Review. Cureus, 16(10), e70923. https://doi.org/10.7759/cureus.70923
Reddy, K., Gharde, P., Tayade, H., Patil, M., Reddy, L. S., & Surya, D. (2023). Advancements in Robotic Surgery: A Comprehensive Overview of Current Utilizations and Upcoming Frontiers. Cureus, 15(12), e50415. https://doi.org/10.7759/cureus.50415
Sartelli, M., Coccolini, F., Kluger, Y., Agastra, E., Abu-Zidan, F. M., Abbas, A. E. S., ... & Catena, F. (2021). WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections. World Journal of Emergency Surgery, 16(1), 49.
Seccombe, A., & Sapey, E. (2018). What is the evidence base for fluid resuscitation in acute medicine? . Clinical medicine (London, England), 18(3), 225–230. https://doi.org/10.7861/clinmedicine.18-3-225
Seudeal, K., Abidi, H., & Shebrain, S. (2018). Early versus delayed appendectomy: A comparison of outcomes. American journal of surgery, 215(3), 483–486. https://doi.org/10.1016/j.amjsurg.2017.10.057
Shinde, V., Dixit, Y., Penmetsa, P., & Nair, K. R. (2024). Clinical and Epidemiological Profile of Patients Presenting With Acute Abdomen to the Emergency Department of a Tertiary Care Hospital. Cureus, 16(8), e67017. https://doi.org/10.7759/cureus.67017
University of Calgary. (2025). Acute abdominal pain. Blackbook: Approaches to Medical Presentations. https://blackbook.ucalgary.ca/schemes/pediatric/acute-abdominal-pain/
Vaghef-Davari, F., Ahmadi-Amoli, H., Sharifi, A., Teymouri, F., & Paprouschi, N. (2019). Approach to Acute Abdominal Pain: Practical Algorithms. Advanced journal of emergency medicine, 4(2), e29. https://doi.org/10.22114/ajem.v0i0.272
WHO Global Initiative for Emergency and Essential Surgical Care. (2020, March 25). https://www.who.int/initiatives/who-global-initiative-for-emergency-and-essential-surgical-care.
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