Prevalence and Determinants of Oral Mucosal Lesions among Tobacco Users
Keywords:
Tobacco use, Oral mucosal lesions, Leukoplakia, Oral submucous fibrosis, PrevalenceAbstract
Objective: To find out the rate of oral mucosal lesions in tobacco users and to explore key related factors with the onset of oral lesions.
Methodology: A cross-sectional study was conducted in 110 habitual tobacco users, who had been in a dental outpatient department. Participants were recruited using a non-probability consecutive sampling technique. The structured questionnaire was used to determine demographic characteristics, nature and duration of tobacco exposure, and frequency of consumption. Statistical analyses were performed to assess associations with a significant level of p values less than 0.05 using statistical techniques such as descriptive statistics and chi-square tests.
Results: The mean age of the participants was 42.7 +- 11.5 years, 70.9 percent were males and 47.3 percent of the sample smoked some form of tobacco who were using smokeless tobacco, and 40.9 percent were smokeless tobacco users consuming a smoked type of tobacco. Oral mucosal lesions were common among this group of people (58.2%), with leukoplakia (19.1%) and oral submucous fibrosis (16.4%) being the most widespread. It was found that the occurrence of lesions was substantially elevated depending on the duration of the use (p = 0.004) as well as smokeless tobacco use (p = 0.03).
Conclusion: Mucosal lesions of the oral mucosa are of high prevalence among users of tobacco, especially the users who are involved in the prolonged or smokeless consumption of tobacco
Downloads
References
Bhandari A, Bhatta N. Tobacco and its relationship with oral health. JNMA: Journal of the Nepal Medical Association. 2021;59(243):1204.
Karshiyeva DR. CHANGES IN THE ORGANS AND TISSUES OF THE ORAL CAVITY OF PEOPLE WHO SMOKE TOBACCO. Журнал гуманитарных и естественных наук. 2023(1):145-9.
Kumari P, Debta P, Dixit A. Oral potentially malignant disorders: etiology, pathogenesis, and transformation into oral cancer. Frontiers in pharmacology. 2022;13:825266.
Zhang S-Z, Xie L, Shang Z-J. Burden of oral cancer on the 10 most populous countries from 1990 to 2019: estimates from the global burden of disease study 2019. International journal of environmental research and public health. 2022;19(2):875.
Sreeramareddy CT, Acharya K. Trends in prevalence of tobacco use by sex and socioeconomic status in 22 sub-Saharan African countries, 2003-2019. JAMA Network Open. 2021;4(12):e2137820-e.
Bogdanska K, Kubik M, Mazur M, Dudek A, Szkudlarek W, Bogdański A, et al. Oral Health Consequences of Smokeless Tobacco Use: A Narrative Review. Cureus. 2025;17(9).
Shetty MS, Sarfaraz H, Saha S. Prevalence of oral mucosal lesions in denture wearers with substance abuse in Mangalore taluk population. JIDA: Journal of Indian Dental Association. 2023;17(9).
Choudhary A, Kesarwani P, Chakrabarty S, Yadav VK, Srivastava P. Prevalence of tobacco-associated oral mucosal lesion in Hazaribagh population: a cross-sectional study. Journal of Family Medicine and Primary Care. 2022;11(8):4705-10.
Acharya S, Singh S, Bhatia SK. Association between Smokeless Tobacco and risk of malignant and premalignant conditions of oral cavity: A systematic review of Indian literature. Journal of Oral and Maxillofacial Pathology. 2021;25(2):371.
Chaudhari MA, Panchal M, Singh N, Fegade T, Sadhu LL. Oral Mucosal Changes Due to Smokeless Tobacco, Betel Quid and Areca Nut: A Review of Risks and Pathology. Journal of Advanced Medical and Dental Sciences Research. 2025;13(4):19-22.
Gombra V, Kaur M, Hasan S, Mansoori S. Smokeless tobacco-and quid-associated localized lesions of the oral cavity: A cross-sectional study from a dental institute. Dental and Medical Problems. 2024;61(5):687-96.
Patil PB, Bathi R, Chaudhari S. Prevalence of oral mucosal lesions in dental patients with tobacco smoking, chewing, and mixed habits: A cross-sectional study in South India. Journal of Family and Community Medicine. 2013;20(2):130-5.
Ramasamy J, Sivapathasundharam B. A study on oral mucosal changes among tobacco users. Journal of Oral and Maxillofacial Pathology. 2021;25(3):470-7.
Ghosh S, Dhungel S, Bhattarai R, Mahanta SK. Prevalence of tobacco-associated oral mucosal lesions in patients visiting a tertiary hospital of Chitwan, Nepal. Nepal Journal of Health Sciences. 2024;4(2):34-41.
Zhang C, Li B, Zeng X, Hu X, Hua H. The global prevalence of oral leukoplakia: a systematic review and meta-analysis from 1996 to 2022. BMC Oral Health. 2023;23(1):645.
Chaitanya NC, Priya SP, Mohammad R, Farghal NS, Hashim NT, Padmanabhan V, et al. Oral Sub-Mucous Fibrosis: A Comprehensive Review of Clinical Features, Pathogenesis, and Management Updates. Journal of International Dental and Medical Research. 2024;17(4):1771-82.
Chatterjee N, Gupte HA, Mandal G. How do adolescents assess and rank the risk of areca nut use? Findings from a study in Mumbai, India. Asian Pacific Journal of Cancer Prevention: APJCP. 2022;23(2):537.
Jerez EL, Nagrani A, Arosemena E. Oral lesions in patients consuming different types of smokeless tobacco. A literature review. Odontología Vital. 2024(41):27-42.
Gupta S, Jain NJ, Jhamtani RC. Chemical Components in Smokeless Tobacco Products and Impact on Health. Toxicology International. 2021;28(4):279-309.
Makena P, Kikalova T, Prasad GL, Baxter SA. Oxidative stress and lung fibrosis: towards an adverse outcome pathway. International Journal of Molecular Sciences. 2023;24(15):12490.
Mohammadpour H, Bakhshi A, Norouzi N, Fallah A, Gharib S. Environmental and genetic risk factors of oral cancer: an updated review. Clinical Cancer Investigation Journal. 2022;11(1-2022):1-8.
Shamsi U, Khan MAA, Qadir MS, Rehman SSU, Azam I, Idress R. Factors associated with the survival of oral cavity cancer patients: a single institution experience from Karachi, Pakistan. BMC Oral Health. 2024;24(1):1427.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.