Effectiveness of Inositol Supplementation in Improving Ovulation Rates in PCOS

Authors

  • Bibi Sajida
  • Memoona Batool
  • Monica Punshi
  • Manesha Juriasinghani
  • Afifa Inayat
  • Nargis Gulab
  • Ramsha Depa

Keywords:

Polycystic Ovary Syndrome, Myo-Inositol, Ovulation, LH/FSH Ratio, Menstrual Irregularity, Hormonal Imbalance, Non-hormonal Therapy

Abstract

Background: To evaluate the effectiveness of myo-inositol supplementation in enhancing ovulation rates and restoring menstrual regularity in women diagnosed with PCOS.

Methods: A prospective interventional study was conducted on 72 women with PCOS from July 2023 to September 2024. Participants received myo-inositol (2000 mg twice daily) with folic acid for 12 weeks. Baseline and post-treatment clinical, biochemical, and ultrasound parameters were recorded. Ovulation was confirmed through mid-luteal progesterone levels or ultrasound follicle monitoring. Pre- and post-treatment data were analyzed using paired t-tests and chi-square tests.

Results: Following inositol supplementation, 58.3% of participants achieved ovulation, and 65.3% reported regular menstrual cycles. There was a significant reduction in LH/FSH ratio and serum testosterone levels (p < 0.001). The therapy was well tolerated, with no major side effects reported.

Conclusion: Myo-inositol supplementation significantly improved ovulation and hormonal profiles in women with PCOS. It may serve as an effective and safe alternative for ovulation induction, particularly in those seeking non-hormonal treatment options.

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Published

2025-09-18

How to Cite

1.
Sajida B, Batool M, Punshi M, Juriasinghani M, Inayat A, Gulab N, Depa R. Effectiveness of Inositol Supplementation in Improving Ovulation Rates in PCOS. J Neonatal Surg [Internet]. 2025Sep.18 [cited 2025Sep.20];13(1):1229-33. Available from: https://jneonatalsurg.com/index.php/jns/article/view/9177

Issue

Vol. 13 (2024): Journal of Neonatal Surgery

Section

Original Article

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