Formulation, Development & Evaluation of Mucoadhesive Buccal Patches For Toothache Relief

Authors

  • Shweta H. Shahare
  • Dipti G. Phadatre
  • Hemlata D. Hire
  • Kalyani K. Bonde
  • Nikita R. Netawate
  • Ketan B. Ghorpade
  • Hemant Y. Mahajan

Keywords:

Thespesia populnea, Thespesia populnea, mucoadhesive Buccal patches, mucoadhesive Buccal patches, HPMC E15, HPMC E15, sodium alginate, sodium alginate, polyethylene glycol 400, polyethylene glycol 400, solvent casting technique, solvent casting technique

Abstract

The present study focuses on the formulation and evaluation of mucoadhesive buccal patches using Thespesia populnea, a plant known for its significant analgesic, anti-inflammatory, and antimicrobial properties, for the effective relief of toothache. The extraction of bioactive constituents was carried out using the Soxhlet method, and the patches were prepared via the solvent casting technique using polymers such as HPMC E15 and sodium alginate. Preliminary and formulation batches were evaluated for various physicochemical parameters including thickness, weight uniformity, folding endurance, surface pH, swelling index, moisture loss, and eggshell membrane permeability. Among all, Batch F8 was found to be optimal, showing desirable mucoadhesive strength, flexibility, and drug permeation characteristics. The study concludes that Thespesiapopulnea mucoadhesive buccal patches offer a promising natural alternative for localized and effective toothache relief. Future prospects involve advanced testing models and in vivo studies to enhance therapeutic efficacy and bioavailability.

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Published

2025-09-12

How to Cite

1.
H. Shahare S, G. Phadatre D, D. Hire H, K. Bonde K, R. Netawate N, B. Ghorpade K, Y. Mahajan H. Formulation, Development & Evaluation of Mucoadhesive Buccal Patches For Toothache Relief. J Neonatal Surg [Internet]. 2025Sep.12 [cited 2025Sep.20];13(1):1135-47. Available from: https://jneonatalsurg.com/index.php/jns/article/view/9138

Issue

Vol. 13 (2024): Journal of Neonatal Surgery

Section

Original Article

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